EFFECT OF PROPOFOL AND MEMANTINE ON ERYTHROCYTE DEFORMABILITY IN DIABETIC RAT MODEL

Abstract

OBJECTIVES: In this study we aimed to investigate the effect of diabetes on erythrocyte deformability (ED) and whether it can be changed by an NMDA antagonist propofol or an NMDA agonist, memantineBACKGROUND: Several clinical studies showed that ED decreases in diabetes. Recent studies showed that erythrocytes have N-methyl-D-aspartate (NMDA) receptors (NMDA Rec) on their membrane.METHODS: Thirty rats were allocated to five groups containing 6 rats each. Memantine was given for 30 days to diabetic rats in one group (group DM) single dose propofol injection is added to this regimen in another group (group DP+ memantine) another group received propofol only (group DP). The remaining groups were controls and diabetic controls. ED was measured in each group and comparedRESULTS: The deformability index was significantly increased in the diabetic rats (p<0.0001). However, it was similar in Group DC and DP (p=0.551), Group DC and DM (p=1.000), Group DC and DPM (p=0.176).CONCLUSION: Neither NMDA antagonist propofol nor NMDA agonist memantine affected the altered red cell rheology in diabetic rat model.