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Journals / ENT Updates / 2020 / Cilt: 10 Sayı: 2

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Yaser Said Cetin(YÜZÜNCÜ YIL ÜNİVERSİTESİ)0000-0002-7684-4600
Ufuk Düzenli(Van Yüzüncü Yıl University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0001-5603-5446
Mehmet Berköz(Yuzuncu Yil University · Faculty of Pharmacy)0000-0003-4219-8054
Hüseyin Özkan(Van Yüzüncü Yıl University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0002-5806-0415
Nazım Bozan(Van Yüzüncü Yıl University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0002-2171-3830
Pages
335–339
Publication Date
2020-08-25
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F2α (8-iso-PGF2α) are indicators of oxidative stress in the human body.
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Key Findings & Data:The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma and to compare them with healthy controls.
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Conclusion & Impact:Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Larynx cancer · oxidative stress · 8-hydroxy-2′-deoxyguanosine

Abstract

Objectives: 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F2α (8-iso-PGF2α) are indicators of oxidative stress in the human body. The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma and to compare them with healthy controls. Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELISA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF2α levels. TNM stages of the patients were recorded from the patient records in the study group. Results: 8-OHdG and 8-iso-PGF2α levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group. Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.

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Cite This Article

Cetin, Y. S., Düzenli, U., Berköz, M., Özkan, H., Bozan, N., *, Y. S. C. (2020). An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma. ENT Updates, Cilt: 10 Sayı: 2, 335–339. https://doi.org/10.32448/entupdates.744725

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