Journals / CURRENT THORACIC SURGERY / 2017 / Cilt: 2 Sayı: 1

Endobronchial Coils – therapeutic innovations for severe emphysema

Pages
30–35
Publication Date
2017-04-16
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To date, the positive benefit-risk ratio of coils is documented by several well-designed randomized clinical trials.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Emphysema is a frequent phenotypic manifestation of chronic obstructive pulmonary diseases which does not respond to pharmacotherapy.
📊
Key Findings & Data:Coils are small, shape-memory Nitinol implants designed to gather and compress lung tissue, re-tension the diseased airway network and increase the elastic recoil in the emphysematous lung.
💡
Conclusion & Impact:To date, the positive benefit-risk ratio of coils is documented by several well-designed randomized clinical trials.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:obstructive pulmonary disease · emphysema · volume reduction

Abstract

Emphysema is a frequent phenotypic manifestation of chronic obstructive pulmonary diseases which does not respond to pharmacotherapy. Interventional methods can provide relief for severely ill and highly symptomatic emphysema patients. A quite well studied endoscopic method is the minimally invasive, non-surgical procedure with coils. Coils are small, shape-memory Nitinol implants designed to gather and compress lung tissue, re-tension the diseased airway network and increase the elastic recoil in the emphysematous lung. To date, the positive benefit-risk ratio of coils is documented by several well-designed randomized clinical trials.

🔖

Cite This Article

Hetzel, M. (2017). Endobronchial Coils – therapeutic innovations for severe emphysema. CURRENT THORACIC SURGERY, Cilt: 2 Sayı: 1, 30–35. https://ajindex.com/articles/984620

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. http://goldcopd.org/gold-2017-global-strategy-diagnosis-management-prevention-copd/ (last accessed: 05.04.2017).
  2. Sanders C, Nath PH, Bailey WC. Detection of emphysema with computed tomography. Correlation with pulmonary function tests and chest radiography. Invest Radiol 1988; 23: 262-6.
  3. Rabe KF. Improving Dyspnea in Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc 2006; 3: 270-5.
  4. Cooper JD, Trulock EP, Triantafillou AN, Patterson GA, Pohl MS, Deloney PA, et al. Bilateral pneumectomy (volume reduction) for chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg 1995; 109: 106-16.
  5. Stirling GR, Babidge WJ, Peacock MJ, Smith JA, Matar KS, Snell GI, et al. Lung Volume Reduction Surgery in Emphysema: A Systematic Review. Ann Thorac Surg 2001; 72: 641-8.
  6. Herth FJ, Eberhard R, Gompelman D, Slebos DJ, Ernst A. Bronchoscopic lung volume reduction with a dedicated coil: a clinical pilot study. Ther Adv Respir Dis 2010; 4: 225-31.
  7. Slebos DJ, Klooster K, Ernst A, Herth FJ, Kerstjens HA. Bronchoscopic Lung Volume Reduction Coil Treatment of Patients With Severe Heterogeneous Emphysema. Chest 2012; 142: 574-82.
  8. Shah PL, Zoumot Z, Singh S, Bicknell SR, Ross ET, Quiring J, et al. Endobronchial coils for the treatment of severe emphysema with hyperinflation (RESET): a randomised controlled trial. Lancet Respir Med 2013; 1: 233-40.
  9. Deslee G, Klooster K, Hetzel M, Stanzel F, Kessler R, Marquette CH, et al. Lung volume reduction coil treatment for patients with severe emphysema: a European multicentre trial. Thorax 2014; 69: 980-6.
  10. Klooster K, ten Hacken NHT, Franz I, Kerstjens HA, van Rikxoort EM, Slebos DJ. Lung Volume Reduction Coil Treatment in Chronic Obstructive Pulmonary Disease Patients with Homogeneous Emphysema: A Prospective Feasibility Trial. Respiration 2014; 88: 116-25.
  11. Hartman JE, Klooster K, Gortzak K, ten Hacken NH, Slebos DJ. Long-term follow-up after bronchoscopic lung volume reduction treatment with coils in patients with severe emphysema. Respirology 2015; 20: 319-26.
  12. Deslee G, Mal H, Dutau H, Bourdin A, Vergnon JM, Pison C, et al. Lung Volume Reduction Coil Treatment vs Usual Care in Patients With Severe Emphysema - The REVOLENS Randomized Clinical Trial. JAMA 2016; 315: 175-84.
  13. Press Release BTG Dec 2015; https://www.btgplc.com/media/press-releases/positive-data-from-renew-study-of-pneumrx-coils/, Download 17.02.2016
  14. Holland AE, SpruitMA, Troosters T, Puhan MA, Pepin V, Saey D, et al. An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J 2014; 44: 1428-46.
  15. Herth FJ, Noppen M, Valipour A, Leroy S, Vergnon JM, Ficker JH, et al. Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort. Eur Respir J 2012; 39: 1334-42.
  16. Cederlund K, Tylen U, Jorfeldt L Aspelin P. Classification of Emphysema in Candidates for Lung Volume Reduction Surgery. Chest 2002; 122: 590-6.
  17. Sciurba FC. Bronchoscopic Lung Volume Reduction in COPD. JAMA 2016; 315:139-41.