AI Summary & Key Takeaways
AI InsightAs a result, we concluded that it is not necessary to give L.M.W.H. after microvascular anastomosis, when there is no endothelial damage and which have repaired with a good microsurgical technique.
📌 3 Key Takeaways
Abstract
Antithrombotic effect of the low molecular weight heparin (L.M.W.H) in microvascular anastomosis was investigated with femoral arteries of the rats. Femoral arteries of 28 rats were cut and anastomosed end to end with microsurgical technique. Rats were divided into two groups and 0.0004 ml/ 100 gr/daily (0.1 axa/U/gr/daily) L.M.W.H. was given to the first group for 7 days and in the second group nothing was given. At the 15 th day all the anastomosis were examined clinically and pathologically, In the first group which had given L.M.W.H. and in the second group, there was no thrombosis formation and arterial flow was normal. As a result, we concluded that it is not necessary to give L.M.W.H. after microvascular anastomosis, when there is no endothelial damage and which have repaired with a good microsurgical technique.
Özet
Mikrovasküler anastomoz sonrası Düşük Molekül Ağırlıklı Heparin'in (D.M.A.H.) antitrombotik etkisi sıçanlarda femoral arter anastomozu yapilip deneysel olarak araştırılmıştır. Yirmisekiz sıçanın femoral arteri kesilerek mikrocerrahi teknikle uç uca anastomoz yapılmıştır. Sıçanlar iki gruba ayrılarak, 1. gruba anastomozdan sonra 7 gün süreyle 0.0004 ml/100 gr/gün (0,1axa U/gr/gün) düz D.M.A.H. subkutan olarak uygulandı. 2. gruba ise herhangi bir antitrombotik ajan verilmedi. Bütün anastomozlar 15. günde klinik ve patolojik olarak incelendi. D.M.A.H uygulanan ve uygulanmayan bütün sıçanlarda mikrovasküler anastomoz bölgesinde trombüs oluşmadığı ve arteriel akımın normal olduğu gözlendi. Endotel hasarı meydana gelmemiş ve tekniğe uygun olarak yapılan mikro arteriyel anastomozlarda, her zaman D.M.A.H. kullanmaya gerek olmadığı sonucuna varıldı.