Journals / Acta Orthopaedica et Traumatologica Turcica / 1997 / Cilt: 31 Sayı: 1

The effect of Tenoxicam on bone repair: A biomechanical study in rats

Tenoksikam'm kemik iyileşmesi üzerine etkisi: Sıçanlarda biyomekanik çalışma

Pages
37–40
Publication Date
2006-09-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Tenoxicam had no statistically significant effect upon the torsional strength of the femora with hole injury and the intact tibiae (p<0.05)

📌 3 Key Takeaways

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Objective & Hypothesis:The effect of tenoxicam on bone repair in the femur of 20 Sprague-Dawley rats (10 control, 10 test) after hole injury was studied using biomechanical methods.
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Key Findings & Data:The test group received 8 mg/kg/day of tenoxicam until the rats were sacrificed on the 21st postoperative day.
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Conclusion & Impact:Tenoxicam had no statistically significant effect upon the torsional strength of the femora with hole injury and the intact tibiae (p<0.05)
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The effect of tenoxicam on bone repair in the femur of 20 Sprague-Dawley rats (10 control, 10 test) after hole injury was studied using biomechanical methods. The test group received 8 mg/kg/day of tenoxicam until the rats were sacrificed on the 21st postoperative day. The torsional strength of the femur (n=32) and the intact tibia (n=32) was measured as the maximum torque capacity in 16 rats. The torsional strengths were as follows: femur control group 0.342 ± 0.061 Nm, test group 0.275 ± 0.037 Nm (p=0.060); tibia control group 0.130 ± 0.021 Nm, test group 0.118 ± 0.043 Nm (p=0.519) . Tenoxicam had no statistically significant effect upon the torsional strength of the femora with hole injury and the intact tibiae (p<0.05)

Özet

Tenoksikam'ın kemik iyileşmesi üzerine etkisini 20 Sprague-Dawley sıçanın (10 deney, W kontrol) femurunda defekt oluşturarak, değerlendirmeye alınan 16'sında biyomekanik yöntemlerle araştırdık. Deney grubuna 8 mg/kg/gün tenoksikam verildi. Sıçanlar 21. günde sakrifiye edildi. Defektli femur (n=32) ve intakt tibiaların (n=32) torsiyonel dayanımı maksimum terk kapasitesi olarak ölçüldü. Torsiyonel dayanım femur için kontrol grubunda 0.342±0.061 Nm, deney grubunda 0.275 ± 0.037 Nm (p=0.060): tibia için kontrol grubunda 0.130 ± 0.021 Nm, deney grubunda 0.118 ± 0.043 Nm (p=0.519) bulundu. Tenoksikamın defektli femur ve intakt tibiaların torsiyonel dayanımı üzerine istatistiksel açıdan anlamlı bir etkisi olmadı (p<0.05).

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Cite This Article

Goksan, S., Atalar, A., Eralp, L. (2006). The effect of Tenoxicam on bone repair: A biomechanical study in rats. Acta Orthopaedica et Traumatologica Turcica, Cilt: 31 Sayı: 1, 37–40. https://ajindex.com/articles/979531

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