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Journals / Acta Orthopaedica et Traumatologica Turcica / 2026 / Cilt: 47 Sayı: 4

The effects of extracorporeal shock waves on carrageenan-induced Achilles tendinitis in rats: a biomechanical and histological analysis

Sıçanlarda karragenan ile uyarılmış Aşil tendinitinde ekstrakorporeal şok dalgalarının etkinliği: Biyomekanik ve histolojik bir değerlendirme

Bekir Cinar
Esra Circi
Cenk Balcik
Gulnur Guven
Sercan Akpinar
Alihan Derincek
Pages
266–272
Publication Date
2013-09-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Low-dose ESW has a negative effect on tendon tensile strength in this animal model.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the influence of low-dose extracorporeal shock waves (ESW) on the healing potential of Achilles tendinitis in the rat.
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Key Findings & Data:Methods: The 36 adult Sprague-Dawley rats used in this study were randomly divided into four groups.
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Conclusion & Impact:Conclusion: Low-dose ESW has a negative effect on tendon tensile strength in this animal model.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Aşil tendiniti · biyomekanik inceleme · ekstrakorporeal şok dalga

Abstract

Objective: The aim of this study was to investigate the influence of low-dose extracorporeal shock waves (ESW) on the healing potential of Achilles tendinitis in the rat. Methods: The 36 adult Sprague-Dawley rats used in this study were randomly divided into four groups. Group A (n=10) were injected with carrageenan, Group B (n=10) were injected with carrageenan and received ESW, Group C (n=10) received ESW only, and Group D (n=6) was a sham group. Rats were injected with 10 microliters of 3% carrageenan or a saline solution eight times during a one-week period with a subcutaneous needle. One week following the final injection, ESW was applied at a rate of 500 impulses in 5 minutes at 2 bars (comparative to 0.09 mJ/mm2) to rats in Groups B and C. Rats were sacrificed three weeks later. Tensile strength, inflammation, and vascularity and collagen density were measured. Results: Failure of the tendon ultimate loads was significantly lower in the study groups than in the control group (p<0.05). Collagen fiber density was higher in the control group than in the other groups (p=0.59). No other histological differences were found. Conclusion: Low-dose ESW has a negative effect on tendon tensile strength in this animal model.

Özet

Amaç: Bu çalışmanın amacı sıçanlarda Aşil tendinitinin iyileşmesinde düşük doz ekstrakorporeal şok dalgaların etkinliğinin incelenmesi idi. Çalışma planı: Çalışmada kullanılan 36 adet Sprague-Dawley sıçanı dört gruba ayrıldı. Grup A, karragenan enjekte edilen 10 sıçan, Grup B karragenan ve ekstrakorporeal şok dalga uygulanan 10 sıçan, Grup C ekstrakorporeal şok dalga uygulanan 10 sıçan ve Grup D kontrol grubu olarak 6 sıçandan oluşmaktaydı. Sıçanlara 10 mikrolitre %3’lük karragenan veya salin çözeltisi bir hafta içinde 8 defa subkutan iğne ile uygulandı. Son enjeksiyondan bir hafta sonra Grup B ve Grup C’deki sıçanlara 500 atım şok dalga 5 dakika süre ile 2 bar (yaklaşık 0.09 mJ/mm2) düzeyinde uygulandı. Sıçanlar üç hafta sonra sakrifiye edildi. Tendon gerim direnci, enflamasyon ve damarlanma ve kolajen yoğunlukları ölçüldü. Bulgular: Çalışma gruplarındaki tendon gerim direncinin kontrol grubuna göre anlamlı düzeyde daha düşük olduğu belirlendi (p<0.05). Kolajen liflerin yoğunluğu kontrol grubunda diğer gruplardan daha yüksekti (p=0.59). Histolojik başka bir farklılık belirlenmedi. Çıkarımlar: Bu hayvan modelinde düşük doz ekstrakorporeal şok dalgasının tendon gerim direncine olumsuz etkisi olduğu görülmüştür.

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Cite This Article

Cinar, B., Circi, E., Balcik, C., Guven, G., Akpinar, S., Derincek, A. (2013). The effects of extracorporeal shock waves on carrageenan-induced Achilles tendinitis in rats: a biomechanical and histological analysis. Acta Orthopaedica et Traumatologica Turcica, Cilt: 47 Sayı: 4, 266–272. https://ajindex.com/articles/979106

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