Journals / Acta Oncologica Turcica / 2014 / Cilt: 47 Sayı: 3

Denosumab Experience in Metastatic Giant Cell Tumor of Bone: Case Series

Metastatik Dev Hücreli Kemik Tümöründe Denosumab Deneyimi: Olgu Serisi

Pages
67–69
Publication Date
2014-12-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Due to the indolent nature of the tumor follow-up period may be short, however we thinks it is an important experience fort his condition

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Giant cell tumor of bone (GCTB) is a rare benign primary tumor of the bone.
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Key Findings & Data:The patient were received between 12-18 months denosumab and remain without disease progression between 6-15 months after discontinuous of treatment.
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Conclusion & Impact:Due to the indolent nature of the tumor follow-up period may be short, however we thinks it is an important experience fort his condition
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:denosumab · dev hücreli kemik tümörü · akciğer metastazı

Abstract

Giant cell tumor of bone (GCTB) is a rare benign primary tumor of the bone. Bisphosphonate therapy is curently used in GCTB because of its anti-osteoclastic effects. Denosumab is fully human monoclonal antibody that inhibit disease progression in metastatic GCTB. We summurized tree patients GCTB patients with lung metastasis. The patient were received between 12-18 months denosumab and remain without disease progression between 6-15 months after discontinuous of treatment. Due to the indolent nature of the tumor follow-up period may be short, however we thinks it is an important experience fort his condition

Özet

Dev hücreli kemik tümörü ( DHKT) nadir görülen benign bir primer kemik tümörüdür. Günümüzde anti osteoklastik aktiviteye sahip bifosfanat tedavisi kullanılmaktadır. Denosumab tamamen insan kaynaklı monoklonal antikordur ve metastatik DHKT'de hastalık progresyonunu inhibe eder. Akciğer metastazı olan 3 DHKT'lü hastayı özetledik. Hastalar 12 ile 18 ay arasında denosumab kullanmışlardı. Tedavi kesilmesinde sonraki 6 ile 15 aylık takipte hastalık progresyonu görülmedi. Hastalık yavaş seyirli olması nedeniyle takip süermiz kısa olabilir ancak bu konuda önemli bir deneyim olduğunu düşünmekteyiz.

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Cite This Article

Ekinci, A. Ş., Eşbah, O., Demirci, A., Özatlı, T., Demirci, U., Budakoğlu, B., Bal, Ö., Öksüzoğlu, Ö. B. (2014). Denosumab Experience in Metastatic Giant Cell Tumor of Bone: Case Series. Acta Oncologica Turcica, Cilt: 47 Sayı: 3, 67–69. https://doi.org/10.5505/aot.2014.38358

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