In this case report, we will retrospectively investigate the diagnosis and treatment management and postoperative clinical outcomes of patients diagnosed with tumors of hematopoietic origin, evaluated by the Bone and Soft Tissue Tumor Council between 2005 and 2021, and emphasize the importance of the approach to these tumors.
📌 3 Key Takeaways
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Objective & Hypothesis:Tumors of hematopoietic origin are rare tumors that can be confused with benign and malignant tumors of the bone with their clinical and morphological features.
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Key Findings & Data:Plasma cell myeloma, solitary plasmacytoma, Non-Hodgkin Lymphoma, acute lymphoblastic leukemia/lymphoma, and Langerhans cell histiocytosis are hematological neoplasms that mainly involve the bone.
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Conclusion & Impact:In this case report, we will retrospectively investigate the diagnosis and treatment management and postoperative clinical outcomes of patients diagnosed with tumors of hematopoietic origin, evaluated by the Bone and Soft Tissue Tumor Council between 2005 and 2021, and emphasize the importance of the approach to these tumors.
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:hematopoetic myelodysplasia · multiple myeloma · bone neoplasms
Abstract
Tumors of hematopoietic origin are rare tumors that can be confused with benign and malignant tumors of the bone with their clinical and morphological features. Plasma cell myeloma, solitary plasmacytoma, Non-Hodgkin Lymphoma, acute lymphoblastic leukemia/lymphoma, and Langerhans cell histiocytosis are hematological neoplasms that mainly involve the bone. Plasma cell myeloma is the most common primary malignant bone neoplasm, and diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma arising in bone. In this case report, we will retrospectively investigate the diagnosis and treatment management and postoperative clinical outcomes of patients diagnosed with tumors of hematopoietic origin, evaluated by the Bone and Soft Tissue Tumor Council between 2005 and 2021, and emphasize the importance of the approach to these tumors.
BÜYÜKCERAN, İ., ŞİMŞEK, Ş. A., MUSLU, O., CENGİZ, T., COŞKUN, H. S., DABAK, N. (2023). Primary malignant bone tumors of hematopoietic origin: A single-center retrospective study. Journal of Experimental and Clinical Medicine, Cilt: 40 Sayı: 3, 619–621. https://ajindex.com/articles/972018
Kim SH, Smith SE, Mulligan ME. Hematopoietic tumors and metastases involving bone. Radiologic Clinics. 2011;49(6):1163-83
Cleven AHG, Hogendoorn PCW. Hematopoietic Tumors Primarily Presenting in Bone. Surgical Pathology Clinics. 2017;10(3):675-91. doi
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J. Bone Pain in Cancer Patients: Mechanisms and Current Treatment. International journal of molecular sciences. 2019;20(23). Epub 2019/12/06. doi: 10.3390/ijms20236047. PubMed PMID: 31801267; PubMed Central PMCID: PMCPMC6928918
Mendenhall WM, Mendenhall CM, Mendenhall NP. Solitary plasmacytoma of bone and soft tissues. American Journal of otolaryngology. 2003;24(6):395-9. Epub 2003/11/11. doi: 10.1016/s0196-0709(03)00092-9. PubMed PMID: 14608572
Hernandez E, Rowan R, Randall M. A Case of Extranodal Metastasis of Primary Bone Lymphoma in the Lower Extremity. Journal of the American Podiatric Medical Association. 2018;108(1):52-7. Epub 2018/03/17. doi: 10.7547/15-115. PubMed PMID: 29547041
Lin P, Huang RF, Xie RT, Zhang YL, Zhuang WH, Zhang XY. [The Types and Laboratory Characteristics of Non-Hodgkin Lymphoma with Bone Marrow Invasion as the First Manifestation]. Zhongguo shi yan xue ye xue za zhi. 2021;29(4):1148-55. Epub 2021/08/08. doi: 10.19746/j.cnki.issn.1009-2137.2021.04.020. PubMed PMID: 34362495
Reisi N, Raeissi P, Harati Khalilabad T, Moafi A. Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature. Orphanet J Rare Dis. 2021;16(1):1. Epub 2021/01/04. doi: 10.1186/s13023-020-01625-z. PubMed PMID: 33388073; PubMed Central PMCID: PMCPMC7778820
Coleman RE, Croucher PI, Padhani AR, Clézardin P, Chow E, Fallon M, et al. Bone metastases. Nature reviews Disease primers. 2020;6(1):83. Epub 2020/10/17. doi: 10.1038/s41572-020-00216-3. PubMed PMID: 33060614
Reich CD. Advances in the treatment of bone metastases. Clinical journal of oncology nursing. 2003;7(6):641- 6. Epub 2004/01/07. doi: 10.1188/03.Cjon.641-646. PubMed PMID: 14705479
Piccioli A, Maccauro G, Spinelli MS, Biagini R, Rossi B. Bone metastases of unknown origin: epidemiology and principles of management. Journal of orthopaedics and traumatology: official journal of the Italian Society of