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Journals / Journal of Scientific Reports-A / 2023 / Sayı: 054

ANTIMICROBIAL ACTIVITY OF PROTON SALTS OF 3-(SULFAMOYLPHENYLCARBAMOYL)ACRYLIC ACID DERIVATIVES WITH AMINOPYRIDINE DERIVATIVES

Halil İLKİMEN
Cengiz YENİKAYA
Aysel GÜLBANDILAR
Pages
264–272
Publication Date
2023-09-30
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The compounds 2 and 4 showed less activity than Fluconazole.

📌 3 Key Takeaways

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Objective & Hypothesis:Ten proton transfer salts (9-18) were synthesized from the reaction of 2-aminopyridine (1), 2-amino-3/4/5/6-methylpyridines (2-5) and 3-aminomethylpyridine (6) with (E)-3-(3/4-sulfamoylphenylcarbamoyl)acrylic acid (7 and 8), respectively.
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Key Findings & Data:Bacillus subtilis (wild culture), Candida albicans (ATCC 14053) (yeast), Enterococcus faecalis (ATCC 29212) (Gram positive), Escherichia coli (ATCC 25922), Listeria monocytogenes (ATCC 7644), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (NRRL B-767) (Gram negative) bacterial microorganisms have been tested against the antimicrobial evaluation of compounds (1–18).
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Conclusion & Impact:The compounds 2 and 4 showed less activity than Fluconazole.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:2-Aminopyridine derivatives · 3/4-(Sulfamoylphenylcarbamoyl) acrylic acid · Proton transfer salt

Abstract

Ten proton transfer salts (9-18) were synthesized from the reaction of 2-aminopyridine (1), 2-amino-3/4/5/6-methylpyridines (2-5) and 3-aminomethylpyridine (6) with (E)-3-(3/4-sulfamoylphenylcarbamoyl)acrylic acid (7 and 8), respectively. Bacillus subtilis (wild culture), Candida albicans (ATCC 14053) (yeast), Enterococcus faecalis (ATCC 29212) (Gram positive), Escherichia coli (ATCC 25922), Listeria monocytogenes (ATCC 7644), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (NRRL B-767) (Gram negative) bacterial microorganisms have been tested against the antimicrobial evaluation of compounds (1–18). Vancomycin, Cefepime, Levofloxacin and the antifungal substance Fluconazole were used as antibacterial reference compounds for comparing the MIC values of 1-18. Compounds 1, 3-6, 8-13, 15, 17 and 18 for E. faecalis, 5 for B. subtilis, 1, 3-12, 15, 17 and 18 for S. aureus, 3, 9, 10, 13, 15 and 17 for L. monocytogenes, 16 for E. Coli and 4 for P. aeruginosa the best effect are observed. Proton transfer salts {9, 14, 15 and 17} were showed higher effect than Fluconazole while other compounds (except compounds 2 and 4) had similar effects with Fluconazole. The compounds 2 and 4 showed less activity than Fluconazole.

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Cite This Article

İLKİMEN, H., YENİKAYA, C., GÜLBANDILAR, A. (2023). ANTIMICROBIAL ACTIVITY OF PROTON SALTS OF 3-(SULFAMOYLPHENYLCARBAMOYL)ACRYLIC ACID DERIVATIVES WITH AMINOPYRIDINE DERIVATIVES. Journal of Scientific Reports-A, Sayı: 054, 264–272. https://ajindex.com/articles/964530

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References (12)

  1. Root, M.J. and MacKinnon, R. (1994). Two identical noninteracting sites in an ion channel revealed by proton transfer. Science, 265, 1852-1856
  2. Armentano, D., De Munno, G., Mastropietro, T. F., Julve, M. and Lloret, F. (2005). Intermolecular proton transfer in solid phase, a rare example of crystal-to-crystal transformation from hydroxo-to oxo-bridged iron (III) molecule-based magnet. Journal of the American Chemical Society, 127, 10778-10779
  3. Chen, K. (2000). Atomically defined mechanism for proton transfer to a buried redox centre in a protein. Nature, 405, 814-817
  4. Chen, K. Y., Lai, C. H., Hsu, C. C., Ho, M. L., Lee, G. H. and Chou, P. T. (2007). Ortho green fluorescence protein synthetic chromophore; excited-state intramolecular proton transfer via a seven-membered-ring hydrogen-bonding system. Journal of the American Chemical Society, 129, 4534-4535
  5. Dellago, C. and Hummer, G. (2006). Kinetics and mechanism of proton transport across membrane nanopores. Physical Review Letters, 97, 245901
  6. Luecke, H., Richter, H.T. and Lanyi, J. K. (1998). Proton transfer pathways in bacteriorhodopsin at 2.3 angstrom resolution. Science, 280, 1934-1937
  7. Heberle, J., Riesle, J., Thiedemann, G., Oesterhelt, D. and Dencher, N. A. (1994). Proton migration along the membrane surface and retarded surface to bulk transfer. Nature, 370, 379-382
  8. Gupta, S. K. S. (2016). Proton transfer reactions in apolar aprotic solvents. Journal of Physical Organic Chemistry, 29, 251-264
  9. Park, S., Kwon, O. H., Kim, S., Park, S., Choi, M. G., Cha, M., Park, S. Y. and Jang, D. J. (2005). Imidazole-based excited-state intramolecular proton-transfer materials, synthesis and amplified spontaneous emission from a large single crystal. Journal of the American Chemical Society, 127, 10070-10074
  10. Moghimi, A., Alizadeh, R., Shokrollahi, A., Aghabozorg, H., Shamsipur, M. and Shockravi, A. (2005). First anionic 1,10-phenanthroline-2,9-dicarboxylate containing metal complex obtained from a novel 1:1 proton−transfer compound, Synthesis, characterization, crystal structure, and solution studies. Inorganic Chemistry, 42, 1616-1624
  11. Nichols, D. A., Hargis, J. C., Sanishvili, R., Jaishankar, P., Defrees, K., Smith, E. W., Wang, K. K., Prati, F., Renslo, A. R., Woodcock, H. L. and Chen, Y. (2015). Ligand-induced proton transfer and low-barrier hydrogen bond revealed by x-ray crystallography. Journal of the American Chemical Society, 137, 8086-8095
  12. Gerlits, O