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Journals / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 86 Sayı: 2

HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?

MMP 9 VE TIMP 1 GENETİK VARYANTLARI VE VİTAMİN D NAZAL POLİPOZİSLİ KRONİK SİNÜZİTTE NASIL ETKİLİDİR?

Meltem Bozacı Kılıçoğlu(Istanbul University, Istanbul Faculty of Medicine, Department of Otorhinolaryngology, Division of Head and Neck Surgery)0000-0001-9952-0329
Baris Ertugrul(ISTANBUL UNIVERSITY, AZIZ SANCAR INSTITUTE OF EXPERIMENTAL MEDICINE, DEPARTMENT OF MOLECULAR MEDICINE)0000-0003-3878-1829
Göksu Kaşarcı(ISTANBUL UNIVERSITY, AZIZ SANCAR INSTITUTE OF EXPERIMENTAL MEDICINE, DEPARTMENT OF MOLECULAR MEDICINE)0000-0001-9766-4361
Şenol Çomoğlu(Istanbul University, Istanbul Faculty of Medicine, Department of Otorhinolaryngology, Division of Head and Neck Surgery)0000-0003-4632-9218
Levent Aydemir(Istanbul University, Istanbul Faculty of Medicine, Department of Otorhinolaryngology, Division of Head and Neck Surgery)0000-0002-5836-4304
Meryem Nesil Keles Türel(Istanbul University, Istanbul Faculty of Medicine, Department of Otorhinolaryngology, Division of Head and Neck Surgery)0000-0003-1829-8186
A Gelincik(Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Allergy and Immunology)0000-0002-3524-9952
Bedia Çakmakoğlu(ISTANBUL UNIVERSITY, AZIZ SANCAR INSTITUTE OF EXPERIMENTAL MEDICINE, DEPARTMENT OF MOLECULAR MEDICINE)0000-0001-7960-9131
Pages
152–158
Publication Date
2023-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study may lead to a further understanding of disease severity in CRSwNP with AERD.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected.
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Key Findings & Data:We investigated the relationship between the genetic polymorphism of MMP9 (rs17576) and TIMP1 (rs48498) and serum levels, and we wanted to investigate the effect of MMP9 and TIMP1 genotypes on Vitamin serum levels in CRSwNP with and without Aspirin-Exacerbated Respiratory Disease (AERD).
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Conclusion & Impact:This study may lead to a further understanding of disease severity in CRSwNP with AERD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nazal polip · MMP9 · TIMP1

Abstract

Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the genetic polymorphism of MMP9 (rs17576) and TIMP1 (rs48498) and serum levels, and we wanted to investigate the effect of MMP9 and TIMP1 genotypes on Vitamin serum levels in CRSwNP with and without Aspirin-Exacerbated Respiratory Disease (AERD). Materials and Methods: This study consisted of 99 patients with CRSwNP with AERD and CRSwNP without AERD. The RTPCR method and ELISA were used in this study. ELISA was used for MMP9 and TIMP1 serum levels and Vitamin D levels. Results: Serum levels of MMP9 were markedly higher in AG genotype than GG genotype in CRSwNP with AERD. Serum levels of MMP9 were statistically higher in carrying of A (+) allele in CRSwNP with AERD than in not carrying of A (+) allele. In addition, serum levels of Vitamin D were discovered significantly lower in TIMP1 CT genotype in comparison to CC and TT genotypes in all of CRSwNP. Conclusion: The rising of MMP9 serum levels may be a marker of chronic inflammation or they may be a significant factor in the resistance to diseases. This study may lead to a further understanding of disease severity in CRSwNP with AERD.

Özet

Amaç: Nazal polipli kronik rinosinüzit sinüs ve nazal mukozanın etkilendiği multifaktöriyel bir hastalıktır. MMP9 (rs17576) ve TIMP1 (rs 4898) genetik polimorfizmleri ile serum düzeyi arasındaki ilişki ve MMP9 ve TIMP1 genotipleri ve Vitamin D arasındaki bağlantının gösterilmesini araştırdık. Gereç ve Yöntem: Bu çalışma, aspirinle alevlenen solunum hastalığı olan veya olmayan nazal polipozisli kronik rinosinüzitli 99 hastadan oluşmaktadır. RT-PCR ve ELISA metodu kullanılmıştır. MMP9, TIMP1 ve Vitamin D serum seviyeleri için ELISA metodu kullanılmıştır. Bulgular: Aspirinle alevlenen solunum hastalığı eşlik eden nazal polipozisli kronik sinüzit hastalarında MMP9 serum seviyesi, AG genotipli hastalarda GG genotipli hastalara kıyasla daha yüksek seviyededir. Aynı zamanda bu hasta grubunda MMP9 serum seviyesi, A (+) alleli taşıyan grupta A (+) alleli taşımayan gruba göre daha yüksek seviyededir. Buna ek olarak TIMP1 CT genotipine sahip olanlar, TIMP1 CC ve TT genotipleri ile kıyaslandığında Vitamin D serum seviyesinin anlamlı olarak düşük olduğu gösterilmiştir. Sonuç: MMP9 serum düzeylerinin yükselmesi, kronik inflamasyonun bir belirteci olabilir veya hastalık direncinde önemli bir faktör olabilir. Bu çalışma, aspirinle alevlenen solunum hastalığı olan nazal polipozisli kronik rinosinüzitte hastalık şiddetinin daha iyi anlaşılmasına yardımcı olabilir.

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Cite This Article

Kılıçoğlu, M. B., Ertugrul, B., Kaşarcı, G., Çomoğlu, Ş., Aydemir, L., Türel, M. N. K., Gelincik, A., Çakmakoğlu, B. (2023). HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?. İstanbul Tıp Fakültesi Dergisi, Cilt: 86 Sayı: 2, 152–158. https://doi.org/10.26650/IUITFD.1210739

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