Journals / Turkish Journal of Gastroenterology / 2012 / Cilt: 23 - Sayı: 6

Selektif geçiş zonu biyopsilerinin rastgele alınan karaciğer biyopsilerine üstünlüğü var mıdır?

Selective transitional zone sampling approach versus random biopsy in cases with malignant liver masses: Is there any superiority?

Pages
708–713
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Selective peripheral biopsy approach in Tru-cut biopsies of liver lesions has better sensitivity rates for histopathologic diagnosis compared to the centrally located and random biopsies.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: Currently, the diagnostic sensitivity of malignant liver mass biopsies is an important problem in the definitive diagnosis.
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Key Findings & Data:Materials and Methods: Between June 2007 and March 2011, totally 88 patients (50 male, 38 female), referred to our Interventional Radiology Department for sonographically guided Tru-cut biopsies for liver lesions, were examined.
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Conclusion & Impact:Conclusions: Selective peripheral biopsy approach in Tru-cut biopsies of liver lesions has better sensitivity rates for histopathologic diagnosis compared to the centrally located and random biopsies.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Background/aims: Currently, the diagnostic sensitivity of malignant liver mass biopsies is an important problem in the definitive diagnosis. In this study, we aimed to investigate the role of selective peripheral approach to lesion biopsies for diagnostic sensitivity of liver masses. Materials and Methods: Between June 2007 and March 2011, totally 88 patients (50 male, 38 female), referred to our Interventional Radiology Department for sonographically guided Tru-cut biopsies for liver lesions, were examined. All biopsies were performed by an experienced radiologist with an 18-gauge Tru-cut biopsy needle with a spring-loaded biopsy gun under sonographic guidance. We describe two locations (peripheral and central) for liver lesions, with the inner 2/3 part of the mass as central and the outer 1/3 part as peripheral. We obtained biopsy from both of these locations, and samples were transferred to the Pathology Department separately. Results: According to pathological and immunohistochemistry studies, there were 42 hepatocellular carcinomas and 46 metastases. All of the metastatic tumors were stained by cytokeratin (10 lung adenocarcinoma, 15 breast adenocarcinoma, 16 gastrointestinal tract, 4 prostate, and 1 malignant melanoma of these 46 metastases were reported as primary). According to histopathological results, diagnostic sensitivity was 97.7% in peripherally located biopsies and 86.3% in biopsies taken from the center of the masses (p=0.0063). Conclusions: Selective peripheral biopsy approach in Tru-cut biopsies of liver lesions has better sensitivity rates for histopathologic diagnosis compared to the centrally located and random biopsies.

Özet

Giriş ve Amaç: Günümüzde malign karaciğer kitle biyopsilerinde kesin tanı konmasında tanısal duyarlılık önemli bir sorundur. Bu çalışmada selektif periferal yaklaşım ile alınan kitle biyopsilerinin tanısal duyarlılıktaki rolünü araştırmayı amaçladık. Gereç ve Yöntem: 2007-2011 yılları arasında ultrasonografi altında karaciğer kitlelerinden biyopsi uygulanmak üzere invaziv Radyoloji Kliniğine yönlendirilen toplam 88 hasta (50 erkek ve 38 kadın) çalışmaya alındı. 18 gauge karaciğer biyopsisi deneyimli radyolog tarafından uygulandı. Bu biyopsilerde iki lokalizasyon tanımlandı: Santral ve periferal. Kitlenin 2/3 merkezi santral, 1/3 dış kısmı ise periferal olarak tanımlandı. Bu çalışmada her iki yerden de biyopsiler ayrı ayrı alınarak değerlendirildi. Bulgular: Patolojik ve immunohistokimyasal çalışmalara göre 42 hastada hepatosellüler kanser ve 46 olguda metastaz saptandı. Tüm metastatik tümörler sitokeratin ile boyandı (10 akciğer adenokarsinomu, 15 meme kanseri, 16 gastrointestinal kaynaklı, 4 prostat ve 1 maliğn melanom öncü odak olarak belirlendi). Histopatolojik sonuçlar dikkate alındığında tanısal duyarlılık %97.7 periferal örneklerde, %86.3 santral biyopsilerde saptandı (p=0,0063). Sonuç: Karaciğer kitle biyopsilerinde selektif periferal biyopsi santralden alınan biyopsilerden daha fazla tanısal duyarlılığa sahiptir.

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Cite This Article

ÇALIŞKAN, K. C., ÖZGÜVEN, M. B. Y., BUĞDACI, M. S., ÇAKMAKÇI, E., ORHAN, U. P., ERTÜRK, M., KARPAT, Z., BAŞAK, M., SELÇUKBİRİCİK, F. (2012). Selektif geçiş zonu biyopsilerinin rastgele alınan karaciğer biyopsilerine üstünlüğü var mıdır?. Turkish Journal of Gastroenterology, Cilt: 23 - Sayı: 6, 708–713. https://ajindex.com/articles/95696

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