SavedAdd your journal

Journals / Van Sağlık Bilimleri Dergisi / 1999 / Cilt: 5 Sayı: 1-2

Diagnostic Importance of Sialic Acid and Lipid-Bound Sialic Acid in Dog with Liver Toxicatioıı

Köpeklerde Karaciğer Toksikasyonunun Tanısında Sialik Asit SA ve Lipid-Bağlı Sialik Asit LSA ’ in Önemi

Zahid T Ağaoğlu(Y.Y.Ü Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Van)
Ayşegül Bildik(Y.Y.Ü Veteriner Fakültesi,Biyokimya Anabilim Dalı Van)
Mehmet Tütüncü(Y.Y.Ü Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Van)
Ali Ertekin(Y.Y.Ü Veteriner Fakültesi,Biyokimya Anabilim Dalı Van)
Nusret Akpolat(Y.Y.Ü Tıp Fakültesi Patoloji Anabilim Dalı Van)
Pages
10–14
Publication Date
1999-06-13
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Serum ALT and ALP levels which has been frequently used for determining liver damages were found statistically important with respect to before toxication values p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:İn this study, the importance of sialic acid SA and lipid-bound sialic acid LSA levels in dogs with Trichloroethylene A group and Carbon tetraclıloride B groııp induced liver toxication were investigated.
📊
Key Findings & Data:İn this study, the importance of sialic acid SA and lipid-bound sialic acid LSA levels in dogs with Trichloroethylene A group and Carbon tetraclıloride B groııp induced liver toxication were investigated.
💡
Conclusion & Impact:Serum ALT and ALP levels which has been frequently used for determining liver damages were found statistically important with respect to before toxication values p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Köpek · Karaciğer toksikasyonu · Sialik asit

Abstract

İn this study, the importance of sialic acid SA and lipid-bound sialic acid LSA levels in dogs with Trichloroethylene A group and Carbon tetraclıloride B groııp induced liver toxication were investigated. Serum ALT and ALP levels which has been frequently used for determining liver damages were found statistically important with respect to before toxication values p

Özet

Bu çalışmada, köpeklerde Trikloretilen A grubu ve Karbon tetraklorür B grubu ile oluşturulan deneysel karaciğer toksikasyonunda sialik asit SA ve lipid-bağlı sialik asit LSA düzeylerinin öneml irdelenmiştir. Karaciğer hasarının belirlenmesinde sıklıkla kullanılan serum ALT ve ALP düzeylerinin toksikasyon öncesi değerlere göre artışı istatistik olarak önemli bulunmuştur p

🔖

Cite This Article

Ağaoğlu, Z. T., Bildik, A., Tütüncü, M., Ertekin, A., Akpolat, N. (1999). Diagnostic Importance of Sialic Acid and Lipid-Bound Sialic Acid in Dog with Liver Toxicatioıı. Van Sağlık Bilimleri Dergisi, Cilt: 5 Sayı: 1-2, 10–14. https://ajindex.com/articles/953054

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (39)

  1. Dunn J (1992) Assesment of Liver Damage and Dysfunction. In Practice. July, 193-200.
  2. Mac Sween RNM, Anthony PR and Scheuer PJ (1987) Pathology of the Liver. Churchill Livingston, New York.
  3. Papich MG and Pavis LE (1985) Drugs and the Liver. Vet. Clin. N. Am. 15: 77-95.
  4. Ettinger SJ (1992) Textbook of Veterinary înternal Medicine Diseases of the Dog and Cat. 2nd ed. W.B. Saunders. Philadelphia. 1479-1527.
  5. Kraft W, Hartmann K, Dereser R (1995) Altersabhangigkeiten Von Laborvverten Bei Hund und Katze. Tierarztl. Prax. 23: 502-508.
  6. Turgut, K. (1995) Veteriner Klinik Laboratuvar Teşhis. Özel Baskı. S.Ü. Vet.Fak. Konya. 155-167.
  7. Schelenberg, F., Beange, F., Bourdin, J., Baurre, J.M. and Weill, J. (1991) Alchol Intoxication and Sialic Acid in Erytrocyte Membrane and in Serum Transferrin. Pharmacology and Biochemistry and Behavior. Vol. 39: 443-447.
  8. Whitehouse, M.V. and Zilliken, F. (1963) Isolation and Determination of Neuraminic (Sialic) Acids: In Methods of Biochemical Analysis. Ed. Glick, D., Interscience Publishers., New York., London., Sydney., Vol. XIII. 199-200.
  9. 9% Gerbaut, L., Rey, E. and Lombart, C. (1973) Improvet Automated Deretmination of Bound N-Acetil Neuraminic Acid in Serum. Clin. Chem., 19,11: 1285-1287.
  10. Tuppy, H. and Gottschalk, A. (1972) The Stuıucture of Sialic Acids and Their Çuantitation. Glycoproteins, Their Composition Sturucture and Function, Revised and Expanded. Second Ed., Elsevier., Amsterdam., London, New York.
  11. Altıntaş, A., Kurtdede, A., Fidancı, U.R., Börkü, M.K. (1989) Köpek Gençlik Hastalığında (Distemper) Serum Sialik Asit ve Protein Düzeylerinin Klinik Önemi. A.Ü. Vet.Fak. Deıg., 36, 1: 154-164.
  12. Carter, A. and Martin, N.H. (1962) Serum Sialic Levels in Healthy and Disease. J. Clin. Path., 15: 69-72.
  13. Colli, A., Buccino, G., Coccila, M., Parravicini, R., Mariani, F. and Scaltrini, G. (1989) Diagnostic Accuracy of Sialic Acid in the Diagnosis of Malignant Ascites, Cancer., 63: 912-916.
  14. Shamberger, R.J. (1984) Serum Sialic Acid in Normals and in Cancer Patients. J. Clin. Chem. Clin. Biochem. 22: 647-651. 15. Singh, B., Choudhuri, P.C., Joshi, H.C. (1980) Serum Mucoprotein and Sialic Acid Enzootic Bovine Haematuria. Zentralblatt Fur Veterinarmedizin 27 A. 8: 678-681.
  15. Stefenelli, N., Klotz, H., Engel, A. and Bauer, P. (1985) Serun Sialic Acid in Malignant Tumors, Bacterial Infections and Cirrhotic Liver Disease. J. Cancer Res. Clin. Oncol., 109: 55-59.
  16. Dnistrian, A.M., Schewartz, M.K., Katapodis, N., Fracchia, A.A. and Stock, C. (1982) Serum Lipid-bound Sialic Acid as a Marker in Breast Cancer, Cancer., 50: 1815-1819.
  17. Erbil, M.K., Jones, J.D. and Klee, G.G. (1985) Use of Serum and Total Sialic Acid as Markers for Colorectal. Cancer., 55. 2: 404-409.
  18. Sydow, G. (1980) A Simplifıed Quick Method For Determination of Sialic Acis in Serum. Biomed. Biochem. Açta. 44, 11/12, 1721-1723.
  19. Katapodis, N., Nirshaut, Y., Geller, N.L. and Stock J. J. (1982) Lipid Associated Silic Acid Test for the Detection of Human Cancer. Cancer Res. 42: 5270-5275.
  20. Hitt, M.E., Hanna, P. and Singh, A. (1992) Percutaneous Transabdominal Hepatic Needle Biopsies in Dogs. Am. J. Vet. Res. May 53. 5: 785- 787.
  21. Jones, B.D., Hitt, M.E., Hurst, T. (1985) Hepatic Biopsy. Vet. Clin. North. Am. Small Anim. Pract. 15: 39-65.
  22. SAS (1995) Survival Analysis Using the SAS System: A Practical Guide. SAS Inst. İne. Cary. NC. USA.
  23. Vörös, K., Szaniszlo, F., Albert, M. And Binder, K. (1991) Ultrasonographic Features of Liver Damage Produced by Experimental Carbontetrachloride Intoxication in the Dog. Proceedings of the XVI. World Congress, World Small Animal Veterinary Association (WSAVA) and VI. National Congress. Vienna, Austria, October. 2. 5:582-583.
  24. Coles, E.H. (1986) Veterinary Clinicaly Pathology. Fourth Ed., W. B. Sounders Comp., London.
  25. Krıshnomurty, V., Rao, R., Gaffer, A.A., Rao, D.S.T. (1994) Certain Serum Enzymes in Dogs with Induced Hepatotoxicity. Indian Vet. J. 71.9: 935-936.
  26. Noonan, N.E. (1981) Variatoins of Plasma Enzymes in the Pony and the Dog After Carbontetrachloride Administration Am. J. Vet. Res. 42. 4: 674-677.
  27. Çenter, S.A., Slater, M.R., Manvvarren, T. and Prymak, K. (1992) Diagnostic Effıcacy of Serum Alkaline Phosphatase and Gamma Glutamyltransferase in Dogs with Histologically Confırmed Hepatobiliary Disease: 270 Cases (1980-1990). J.A.W.M.A. 201.8:1258-1264.
  28. Engen, R.L. (1971) Serum Sialic Acid Values in Dogs with Canine Distemper. Am. J. Vet. Res., 32. 6: 803-804.
  29. Plucinsky, M.C., Riley, W.M., Prorok, J.J., at ali. (1986) Total and Lipid Associated Serum Sialic Acid Levels in Cancer Patients with Differet Primary Sites and Degrees of Metastatic Involvement. Cancer., 58: 2680-2685.
  30. Lai, E.K., McCay, P.B., Noguchi, T. and Fong, K.L. (1979) In Vivo Spintrapping of Trichloromethylradicals Formed from CCU. Biochem. Pharmacol. 28: 2231-2235.
  31. Payer, J.L., Floyd, R.A., McCay, P.B., Janzen, E.G. and Davis, E.R. (1978) Spintrapping of Trichloromethyl Radical Produced During Enzymatic NADPH Oxydation in the Presence of Carbontetrachloride or Bromotrichloromethane. Bioc. Biophys. Açta. 539: 402-409.
  32. Payer, J.L., McCay, P.B., Lai, E.K., Janzen, E.G. and Davis, E.R. (1980) Conformation of assignment of the Trichloromethyl Radical Spinadduct Detected by Spintrapping During 13C-Carbontetrachloride Metabolism in Vitro and in Vivo. Biochem. Biophy. Res. Commun. 94: 1154-1160.
  33. Recknagel, R.O., Glende, E.A., Hruszkewycz, A.M. and Dryor, W.A. (1977) Free Radicals in Biology. Vol. 3, New York Academic Press, 97- 132.
  34. Vural, N. (1984) Toksikoloji. A.Ü. Ecz. Fak. Yay. No:56. Ankara, 283-286.
  35. Frank, H., Link, B. (1984) Anaerobic Metabolism of Carbon Tetrachloride and Formation of Catabolically Resistant Phospholipids. Biochem. Pharmacol. 33; 1127-1130.
  36. Mc Cay, P.B. Lai, E.K., Payer, J.L., Dubose, C.M. and Janzen, E.G. (1984) Oxygen and Carbon Centered Radical Formation During Carbon Tetrachloride Metabolism. J. Biol. Chem. 259: 2135-2143.
  37. Pohl, L.R., Miço, B.A. (1984) Electrophilic Halogens as potentially Toxic Metabolites of Halogenated Conpounds. Trends in Pharmacological Science. 5: 61-64.
  38. Schelenberg, F., Beange, F., Bourdin, J., Baurre, J.M. and Weill, J. (1991) Alchol Intoxication and Sialic Acid in Erytrocyte Membrane and in Serum Transferrin. Pharmacology and Biochemistry and Behavior. Vol. 39: 443-447.
  39. Lai, E.K., McCay, P.B., Noguchi, T. and Fong, K.L. (1979) In Vivo Spintrapping of Trichloromethylradicals Formed from CCU. Biochem. Pharmacol. 28: 2231-2235.