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Journals / Sakarya University Journal of Science / 2022 / Cilt: 26 Sayı: 4

Metal-containing Coordination Complexes (MCCs): Assessment of Biological Activity with Helicobacter pylori Caused Gastric Ulcer

Dursun KISA
Yusuf CEYLAN
Merve YILDIRIM
Sümeyra DURGUN
Nesrin KORKMAZ
Pages
768–775
Publication Date
2022-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The synthesized compounds have effective inhibitory potential with IC50 value between 26.65±1.21 and 12.37±0.87 µM for urease.

📌 3 Key Takeaways

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Objective & Hypothesis:The ulcer is a vital disease that unfavorably affects human health globally.
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Key Findings & Data:In the current study, antibacterial characteristic of (C1), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O), and (C2), ([Ni(hydeten)2Ag(CN)2][Ag(CN)2], MCC were analyzed by disk diffusion and broth dilution broth and urease enzyme inhibition assays were performed.
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Conclusion & Impact:The synthesized compounds have effective inhibitory potential with IC50 value between 26.65±1.21 and 12.37±0.87 µM for urease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Metal coordination complexes · Helicobacter pylori · antibacterial

Abstract

The ulcer is a vital disease that unfavorably affects human health globally. Helicobacter pylori, a reason forhave an antibacterial effect against ulcers and some stomach disorders, live on using the urease enzyme and induces the condition to occur. Metal coordination complexes (MCC) are used in numerous industrial areas and the health field. Cyanide bridged metal complexes are also applied in several places. In the current study, antibacterial characteristic of (C1), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O), and (C2), ([Ni(hydeten)2Ag(CN)2][Ag(CN)2], MCC were analyzed by disk diffusion and broth dilution broth and urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and C2 were observed to provide favorable effects. The synthesized compounds have effective inhibitory potential with IC50 value between 26.65±1.21 and 12.37±0.87 µM for urease.

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Cite This Article

KISA, D., CEYLAN, Y., YILDIRIM, M., DURGUN, S., KORKMAZ, N. (2022). Metal-containing Coordination Complexes (MCCs): Assessment of Biological Activity with Helicobacter pylori Caused Gastric Ulcer. Sakarya University Journal of Science, Cilt: 26 Sayı: 4, 768–775. https://ajindex.com/articles/941431

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