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Journals / Experimed / 2023 / Cilt: 13 Sayı: 1

Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages

D. Fulya KIZILGEDİK
Armagan CANER
Çağlar YILDIZ
Buğra OKŞAŞOĞLU
Sema MISIR
İlhan YAYLIM
Semra DEMOKAN
Ceylan HEPOKUR
Journal
Experimed
Pages
15–20
Publication Date
2023-05-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Endometriosis is a gynecological disease associated with chronic pelvic inflammation, pain, and infertility.
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Key Findings & Data:Galectin-3 (Gal-3) is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis.
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Conclusion & Impact:Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Galectin-3 · endometriosis · biomarkers

Abstract

Objective: Endometriosis is a gynecological disease associated with chronic pelvic inflammation, pain, and infertility. Galectin-3 (Gal-3) is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis. This study aimed to elucidate the importance of Gal-3 in endometriosis, to reveal its potential power as a non-invasive diagnostic biomarker in disease etiopathogenesis. Materials and Methods: The serum concentration of Gal-3 and cancer antigen 125 (CA-125) from whole blood were measured using enzyme-linked immuno sorbent assay (ELISA) and an auto-analyzer, respectively. Gal-3 expression was determined by quantitative real-time polymerase chain reaction (qRT-PCR) from peripheral blood. Results: We found significant differences for Gal-3 expression levels between the endometriosis and control groups (p <0.05). Gal-3 levels in the serum of women with endometriosis are also remarkably increased compared with the control group. Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area

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Cite This Article

KIZILGEDİK, D. F., CANER, A., YILDIZ, Ç., OKŞAŞOĞLU, B., MISIR, S., YAYLIM, İ., DEMOKAN, S., HEPOKUR, C. (2023). Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. Experimed, Cilt: 13 Sayı: 1, 15–20. https://ajindex.com/articles/936350

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