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Journals / Osmangazi Tıp Dergisi / 2026 / Cilt: 42 Sayı: 3

Evaluation of the Relationship of Paraoxonase 1 L55M and Q192R Polymorphism in Postmenopausal Osteoporosis

Postmenopozal Osteoporozda Paraoksonaz 1 L55M ve Q192R Polimorfizminin İlişkisinin Değerlendirilmesi

Merih Özgen(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8919-968X
Didem Turgut Coşan(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8488-6405
Zeliha Atik(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-7111-3529
Faruk Saydam(Recep Tayyip Erdogan University)0000-0003-2358-8719
Emine Çolak(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6293-2909
Ahu Soyocak(ISTANBUL AYDIN UNIVERSITY)0000-0003-0999-2774
Fulya Doğaner(AKSARAY ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6543-8447
Funda Berkan(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-7531-3704
İrfan Değirmenci(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7074-1694
Fezan Mutlu0000-0002-9339-4031
Pages
289–295
Publication Date
2020-05-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PON1 172T>A (Leu55Met) gene polymorphism was associated with postmenopausal osteoporosis in our study.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Osteoporosis is a systemic disease which is common in society, characterized by bone micro-architecture deterioration and low bone mass.
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Key Findings & Data:The aim of our study was to determine whether paraoxonase 1 ( PON1 ) gene correlates with 584A>G (Gln192Arg) and 172T>A (Leu55Met) polymorphisms with postmenopausal osteoporosis.
💡
Conclusion & Impact:PON1 172T>A (Leu55Met) gene polymorphism was associated with postmenopausal osteoporosis in our study.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Osteoporoz · PON1 · Gen polimorfizm

Abstract

Osteoporosis is a systemic disease which is common in society, characterized by bone micro-architecture deterioration and low bone mass. The aim of our study was to determine whether paraoxonase 1 ( PON1 ) gene correlates with 584A>G (Gln192Arg) and 172T>A (Leu55Met) polymorphisms with postmenopausal osteoporosis. A total of 143 postmenopausal osteoporosis and 102 healthy women who were followed up in Eskişehir Osmangazi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation were included in the study. The study was planned retrospectively. Genotypes were identified on the qPCR (The Applied Biosystems® StepOne ™) using the allele-specific DNA primer and fluorescent-specific DNA probe. There was no statistically significant difference between the groups in the genotype and allele frequencies of PON1 584A>G polymorphism (p=0.362 and p= 0.318). When the genotype and allele frequencies of PON1 172T>A polymorphism were compared, it was observed that T allele was significantly higher in postmenopausal osteoporosis than healthy subjects (p <0.001, p <0.001, respectively). PON1 172T>A (Leu55Met) gene polymorphism was associated with postmenopausal osteoporosis in our study.

Özet

Osteoporoz, toplumda yaygın görünen, kemik mikro mimarisinde bozulma ve düşük kemik kütlesi ile karakterize sistemik bir hastalıktır. Çalışmamızın amacı paraoksonaz (PON1) geninin 584A>G(Gln192Arg) ve 172T>A(Leu55Met) polimorfizmleri ile postmenopozal osteoporoz ile ilişkisinin olup olmadığını saptamaktır. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı Kliniği’nde takipli 143 postmenopozal osteoporozu olan ve 102 sağlıklı kadın çalışmaya dahil edildi. Çalışma retrospektif olarak planlandı. Genotipler alel-spesifik DNA primeri ve floresan özellikli DNA probu kullanılarak qPCR cihazında (The Applied Biosystems® StepOne™) belirlendi. PON1 584A>G polimorfizminin genotip ve alel frekanslarında gruplar arasında istatistiksel olarak anlamlı bir fark bulunmamıştır ( p =0.362 ve p =0.318). PON1 172T>A polimorfizminin genotip ve alel frekansları karşılaştırıldığında ise, sağlıklı bireylere göre postmenopozal osteoporozu olanlarda T alelinin istatistiksel olarak anlamlı derecede yüksek bulunduğu (sırasıyla p <0.001, p <0.001) gözlendi. Çalışmamızda PON1 172T>A(Leu55Met) gen polimorfizmi ile postmenopozal osteoporoz arasında ilişki olduğu gösterildi.

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Cite This Article

Özgen, M., Coşan, D. T., Atik, Z., Saydam, F., Çolak, E., Soyocak, A., Doğaner, F., Berkan, F., Değirmenci, İ., Mutlu, F. (2020). Evaluation of the Relationship of Paraoxonase 1 L55M and Q192R Polymorphism in Postmenopausal Osteoporosis. Osmangazi Tıp Dergisi, Cilt: 42 Sayı: 3, 289–295. https://doi.org/10.20515/otd.534456

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