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Journals / İstanbul Journal of Pharmacy / 2016 / Cilt: 46 - Sayı: 1

Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications

İmren ESENTÜRK
M. Sedef ERDAL
Sevgi GÜNGÖR
Pages
49–69
Publication Date
2016-08-24
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications.The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics.This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends.This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size.
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Key Findings & Data:Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size.
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Conclusion & Impact:Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications.The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics.This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends.This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Nanofiber · electrospinning · topical drug delivery

Özet

Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications.The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics.This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends.This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.

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Cite This Article

ESENTÜRK, İ., ERDAL, M. S., GÜNGÖR, S. (2016). Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications. İstanbul Journal of Pharmacy, Cilt: 46 - Sayı: 1, 49–69. https://ajindex.com/articles/92743

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