SavedAdd your journal

Journals / Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni / 2021 / Cilt: 12 Sayı: 1

CYTOKINES AND THE USE OF CYTOKINES AS VACCINE ADJUVANT IN POULTRY

SİTOKİNLER VE KANATLILARDA SİTOKİNLERİN AŞI ADJUVANTI OLARAK KULLANIMI

Aziz Utku ÖNEL
Murat YILDIRIM
Pages
21–32
Publication Date
2021-05-07
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, we aimed to give information about the types and functional properties of avian cytokines and the use of cytokines as vaccine adjuvants.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Prevention and treatment of diseases in poultry is provided by the use of vaccines and antibiotics.
📊
Key Findings & Data:Therefore, the development of new vaccine strategies has become a crucial issue in the poultry industry.
💡
Conclusion & Impact:In this review, we aimed to give information about the types and functional properties of avian cytokines and the use of cytokines as vaccine adjuvants.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Adjuvant · aşı · kanatlı immunolojisi

Abstract

Prevention and treatment of diseases in poultry is provided by the use of vaccines and antibiotics. The use of antibiotics for many years has brought problems with the emergence of antibiotic-resistant bacteria. Adjuvants in vaccine used in the prevention of diseases may have adverse health effects and may inadequately stimulate the immune response. Therefore, the development of new vaccine strategies has become a crucial issue in the poultry industry. Cytokines are peptides that enable the activation and regulation of immune system cells secreted by cells that play a vital role in inflammation reactions. Avian immunology and genetic components have led to the discovery of various cytokines, especially in chicken and to understand the functional properties and mechanisms of these cytokines. Many studies have been conducted on the use of cytokines as a potential vaccine adjuvant in vaccines used against infectious agents in poultry. In this review, we aimed to give information about the types and functional properties of avian cytokines and the use of cytokines as vaccine adjuvants.

Özet

Kanatlı hayvanlarda hastalıkların önlenmesi ve sağaltımı aşıların ve antibiyotiklerin kullanılması ile sağlanır. Antibiyotiklerin uzun yıllar boyunca kullanılması antibiyotiğe dirençli bakterilerin ortaya çıkması ile ilgili sorunları beraberinde getirmiştir. Hastalıkların önlenmesinde kullanılan aşılardaki adjuvantlar, sağlık üzerinde yan etkilere sahip olabilir ve immun yanıtı yetersiz bir şekilde uyarabilir. Bu nedenle kanatlı endüstrisinde yeni aşı stratejilerinin geliştirilmesi oldukça önemli bir konu haline gelmiştir. Sitokinler, yangı reaksiyonlarında hayati rol oynayan hücreler tarafından salgılanan immun sistem hücrelerinin aktivasyonu ve düzenlenmesini sağlayan peptitlerdir. Kanatlı immunolojisi ve genetik alanındaki gelişmeler, özellikle tavukta çeşitli sitokinlerin keşfedilmesine ve bu sitokinlerin işlevsel özelliklerinin ve mekanizmalarının anlaşılmasını sağlamıştır. Kanatlı hayvanlarda enfeksiyöz ajanlara karşı kullanılan aşılarda sitokinlerin potansiyel bir aşı adjuvantı olarak kullanılması yönünde birçok çalışma gerçekleştirilmiştir. Bu derlemede kanatlı sitokinlerinin çeşitleri, fonksiyonel özellikleri ve sitokinlerin aşı adjuvantı olarak kullanımı hakkında bilgi vermek amaçlandı.

🔖

Cite This Article

ÖNEL, A. U., YILDIRIM, M. (2021). CYTOKINES AND THE USE OF CYTOKINES AS VACCINE ADJUVANT IN POULTRY. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, Cilt: 12 Sayı: 1, 21–32. https://ajindex.com/articles/915572

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Asif, M., Jenkins, K.A., Hilton, L.S., Kimpton, W.G., Bean, A.G., Lowenthal, J.W. (2004). Cytokines as adjuvants for avian vaccines. Immunology and Cell Biology, 82(6), 638–643.
  2. Chen, W.T., Chang, H.K., Lin, C.C., Yang, S.M., Yin, H.S. (2017). Chicken interleukin-1β mutants are effective single-dose vaccine adjuvants that enhance mucosal immune response. Molecular Immunology, (87), 308-316.
  3. Cohen, S., Bigazzi, P., Yoshida, T. (1974). Similarities of thymus-derived lymphocyte function in cell-mediated immunity and antibody production. Cellular Immunology, (12), 150-159.
  4. Cui, D., Zhang, J., Zuo, Y., Huo, S., Zhang, Y., Wang, L., Li, X., Zhong, F. (2018). Recombinant chicken interleukin-7 as a potent adjuvant increases the immunogenicity and protection of inactivated infectious bursal disease vaccine. Veterinary Research, 49(1), 10. Darnell, J.J. (1997). STATs and gene regulation. Science (New York, N.Y.) (277 (5332)), 1630–1635.
  5. De Boever, S., Croubels, S., Demeyere, K., Lambrecht, B., De Backer, P., Meyer, E. (2010). Flow cytometric differentiation of avian leukocytes and analysis of their intracellular cytokine expression. Avian Pathology, (39), 41-46.
  6. Degen, W.G., van Zuilekom, H.I., Scholtes, N.C., van Daal, N., Schijns, V.E. (2005). Potentiation of humoral immune responses to vaccine antigens by recombinant chicken IL-18 (rChIL-18). Vaccine, (23), 4212-4218.
  7. Djeraba, A., Musset, E., Lowenthal, J.W., Boyle, D.B., Chausse, A.M., Peloille, M., Quere, P. (2002). Protective Effect of Avian Myelomonocytic Growth Factor in Infection with Marek's Disease Virus. Journal of Virology, 1062-1070.
  8. Downing, T., Lloyd, A., O'farrelly, C., Bradley, D.G. (2010). The Differential Evolutionary Dynamics of Avian Cytokine and TLR Gene Classes. The Journal of Immunology, (184), 6993-7000.
  9. Gan, L., Tian, Y., Zhao, Y., Shan, X.Q., Zhou, W., Xia, B.B., Chen, J., Wang, M.L., Zhao, J. (2019). Enhancing immunogenicity and protective efficacy of inactivated avian influenza H9N2vaccine with recombinant chicken IFN-α in chicken. Veterinary Microbiology, (234), 77-82.
  10. Hilton, L., Bean, A., Lowenthal, J. (2002). The emerging role of cytokines as immunotherapeutic and adjuvants in vaccine. Veterinary Immunology and Immunopathology, 85 (3-4), 119-128.
  11. Hung, L.H., Li, H.P., Lien, Y.Y., Wu, M.L., Chaung, H.C. (2010). Adjuvant effects of chicken interleukin-18 in avian Newcastle disease vaccine. Vaccine, (28), 1148-1155.
  12. Huo, S., Zuo, Y., Li, N., Zhang, Y., Wang, L., Liu, H., Zhang, J., Cui