Journals / Koşuyolu Heart Journal / 2017 / Cilt: 20 - Sayı: 2

A New Marker for Ischemia: Ischemia-modified Albumin

İskemide Yeni Bir Marker: İskemi Modifiye Albumin

Pages
148–152
Publication Date
2017-08-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, we investigated the pathophysiology, analysis and clinical utility of ischemia-modified albumin.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ischemia-modified albumin constitutes via a modifcation in albumin where reactive oxygen species are formed due to ischemia.
📊
Key Findings & Data:Albumin is measured using the cobalt binding test, and this test is used for the determination of albumin prior to the development of permanent cardiac injuries.
💡
Conclusion & Impact:In this review, we investigated the pathophysiology, analysis and clinical utility of ischemia-modified albumin.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:İskemi modifiye albumin · iskemi · akut koroner sendrom

Abstract

Ischemia-modified albumin constitutes via a modifcation in albumin where reactive oxygen species are formed due to ischemia. Albumin is measured using the cobalt binding test, and this test is used for the determination of albumin prior to the development of permanent cardiac injuries. In this review, we investigated the pathophysiology, analysis and clinical utility of ischemia-modified albumin.

Özet

İskemi modifiye albumin iskemi sonucu oluşan reaktif oksijen türevlerinin yol açtığı albuminde modifikasyon ile oluşur. Albumin kobalt bağlama testi kullanılarak ölçülür. Bu test geçici olmayan kardiyak hasarın başlangıcından önce iskeminin erken saptanmasında kullanılır. Bu yazıda iskemi modifiye albuminin patofizyolojisi, analizi ve klinik uygulamalarını inceledik.

🔖

Cite This Article

CAN, Ü., YOSUNKAYA, Ş. (2017). A New Marker for Ischemia: Ischemia-modified Albumin. Koşuyolu Heart Journal, Cilt: 20 - Sayı: 2, 148–152. https://ajindex.com/articles/91004

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Chawla R, Goyal N, Calton R, Goyal S. Ischemia modified albumin: A novel marker for acute coronary syndrome. Indian J Clin Biochem 2006;21:77-82
  2. Gaze DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab Pharmacokinet 2009;24:333-41
  3. Lee E, Eom JE, Jeon KH, Kim TH, Kim E, Jhon GJ, et al. Evaluation of albumin structural modifications through cobalt-albumin binding (CAB) assay. J Pharm Biomed Anal 2014;91:17-23
  4. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med 2011;49:177-84
  5. Worster A, Devereaux PJ, Heels-Ansdell D, Guyatt GH, Opie J, Mookadam F, et al. Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome. CMAJ 2005;172:1685-90
  6. Erdem SS, Yerlikaya FH, Çiçekler H, Gül M. Association between ischemia-modified albumin, homocysteine, vitamin B(12) and folic acid in patients with severe sepsis. Clin Chem Lab Med 2012;50:1417-21
  7. Zurawska-Płaksej E, Grzebyk E, Marciniak D, Szymańska-Chabowska A, Piwowar A. Oxidatively modified forms of albumin in patients with risk factors of metabolic syndrome. J Endocrinol Invest 2014;37:819-27
  8. Piwowar A, Knapik-Kordecka M, Warwas M. Ischemia-modified albumin level in type 2 diabetes mellitus-Preliminary report. Dis Markers 2008;24:311-7
  9. Eom JE, Lee E, Jeon KH, Sim J, Suh M, Jhon GJ, et al. Development of an albumin copper binding (ACuB) assay to detect ischemia modified albumin. Anal Sci 2014; 30:985-90
  10. Ellidag HY, Bulbuller N, Eren E, Abusoglu S, Akgol E, Cetiner M, et al. Ischemia-modified albumin: could it be a new oxidative stress biomarker for colorectal carcinoma? Gut Liver 2013;7:675-80
  11. Sbarouni E, Georgiadou P, Kremastinos DT, Voudris V. Ischemia modified albumin: is this marker of ischemia ready for prime time use? Hellenic J Cardiol 2008;49:260-6
  12. Ertekin B, Kocak S, Defne Dundar Z, Girisgin S, Cander B, Gul M, et al. Diagnostic value of ischemia-modified albumin in acute coronary syndrome and acute ischemic stroke. Pak J Med Sci 2013;29:1003-7
  13. Anwaruddin S, Januzzi JL Jr, Baggish AL, Lewandrowski EL, Lewandrowski KB. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Am J Clin Pathol 2005;123:140-5
  14. Christenson RH, Duh SH, Sanhai WR, Wu AH, Hol