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Journals / Current Research in Dental Sciences / 2021 / Cilt: 31 Sayı: 1

İLACA BAĞLI ÇENE KEMİĞİ OSTEONEKROZU: BİR DERLEME

Mehmet Melih ÖMEZLİ
Ferhat AYRANCI
Damla TORUL
Emine ÖRNEK AKDOĞAN
Pages
115–123
Publication Date
2021-01-15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Keywords: osteonecrosis, bisphosphonate, denosumab, bevacizumab

📌 3 Key Takeaways

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Objective & Hypothesis:İlaca Bağlı Çene Kemiği Osteonekrozu: Bir Derleme İlaca Bağlı Çene Kemiği Osteonekrozu (MRONJ) bifosfonatlar yanında antiosteoklastik ve antianjiyojenik aktiviteye sahip ilaçların kullanımı sonucu ortaya çıkan, maksilla ve mandibulada nekrotik kemik varlığı ile karakterize bir komplikasyondur.
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Key Findings & Data:Bu derlemenin amacı ilaca bağlı çene kemiği osteonekrozunun etyopatolojisi ve güncel tedavi stratejilerini literatür ışığında sunmaktır.
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Conclusion & Impact:Keywords: osteonecrosis, bisphosphonate, denosumab, bevacizumab
🔬Design:Experimental Field Trial
📍Scope:Comprehensive Sample
⚙️Variables:osteonekroz · bifosfonat · denosumab

Özet

İlaca Bağlı Çene Kemiği Osteonekrozu: Bir Derleme İlaca Bağlı Çene Kemiği Osteonekrozu (MRONJ) bifosfonatlar yanında antiosteoklastik ve antianjiyojenik aktiviteye sahip ilaçların kullanımı sonucu ortaya çıkan, maksilla ve mandibulada nekrotik kemik varlığı ile karakterize bir komplikasyondur. Hem hekimler hem de hastalar için ciddi bir problem oluşturan bu özgün komplikasyonun optimum düzeyde yönetimini sağlayarak hastaların ekonomik ve sosyal mağduriyetlerini önleyecek tedavi protokolü ile ilgili bir fikir birliği bulunmamaktadır. Bu derlemenin amacı ilaca bağlı çene kemiği osteonekrozunun etyopatolojisi ve güncel tedavi stratejilerini literatür ışığında sunmaktır. Anahtar kelimeler: osteonekroz, bifosfonat, denosumab, bevacizumab Medication Related Osteonecrosis of the Jawbones: A Review ABSTRACT Medication Related Osteonecrosis of the Jawbones: A Review Medication Related Osteonecrosis of the Jaws (MRONJ) is a complication characterized by the appearance of necrotic bone in the maxilla and mandible, resulting from the use of bisphosphonates as well as drugs with antiosteoclastic and antiangiogenic activity. No consensus has been reach regarding the treatment protocol that will prevent the economic and social burden of the patients by providing optimum management of this unique complication which constitutes a serious problem for both physicians and patients. The aim of this review is to present the etiopathology and current treatment strategies of Medication Related Osteonecrosis of the Jaws in the light of the literature. Keywords: osteonecrosis, bisphosphonate, denosumab, bevacizumab

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Cite This Article

ÖMEZLİ, M. M., AYRANCI, F., TORUL, D., AKDOĞAN, E. Ö. (2021). İLACA BAĞLI ÇENE KEMİĞİ OSTEONEKROZU: BİR DERLEME. Current Research in Dental Sciences, Cilt: 31 Sayı: 1, 115–123. https://ajindex.com/articles/900948

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References (13)

  1. Aslan Ö, Vural H, Kömürcü Ş, Özet A. Kemoterapi Alan kanser hastalarina verilen eğitimin kemoterapi semptomlarina etkisi. CÜ Hemsirelik Yüksekokulu Derg 2006;10:15-28
  2. Ribeiro GH, Chrun ES, Dutra KL, Daniel FI, Grando LJ. Osteonecrosis of the jaws: a review and update in etiology and treatment. Braz J Otorhinolaryngol 2018;84:102-8
  3. Manea HC, Urechescu HC, Balica NC, Pricop MO, Baderca F, Poenaru M, Horhat ID, Jifcu EM, Closca RM, Sarau CA. Bisphosphonates-induced osteonecrosis of the jaw - epidemiological, clinical and histopathological aspects. Rom J Morphol Embryol 2018;59:825-31
  4. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003;61:1115-7
  5. Crepin S, Laroche ML, Sarry B, Merle L. Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review. Eur J Clin Pharmacol 2010;66:547-54
  6. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw - 2009 update. Aust Endod J 2009;35:119-30
  7. Estilo CL, Fornier M, Farooki A, Carlson D, Bohle G, 3rd, Huryn JM. Osteonecrosis of the jaw related to bevacizumab. J Clin Oncol 2008;26:4037-8
  8. King R, Tanna N, Patel V. Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab-a review. Oral Surg Oral Med Oral Pathol Oral Radiol 2019;127:289-99
  9. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg 2014;72:1938-56
  10. Topaloglu G, Koseoglu OT, Karaca C, Kosemehmetoglu K. The effect of chronic dental inflammation on development of Stage 0 medication-related osteonecrosis of the jaw. J Craniomaxillofac Surg 2017;45:1158-64
  11. Kang MH, Lee DK, Kim CW, Song IS, Jun SH. Clinical characteristics and recurrence-related factors of medication-related osteonecrosis of the jaw. J Korean Assoc Oral Maxillofac Surg 2018;44:225-31
  12. Roelofs AJ, Thompson K, Gordon S, Rogers MJ. Molecular mechanisms of action of bisphosphonates: current status. Clin Cancer Res 2006; 12:6222s-30s
  13. Lemound J, Muecke T, Zeller AN, Lichtenstein J, Eckardt A, Gellrich NC. Nasolabial Flap improves healing in medication-related osteonecrosis of the jaw. J Ora