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Journals / Sigma Journal of Engineering and Natural Sciences / 2015 / Cilt: 33 Sayı: 3

EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES

Hatice İmran GÜNGÖRDÜ
Nil Erge AKKAYA
Ahmet GİZ
Huceste ÇATALGİL GİZ
Pages
407–416
Publication Date
2015-09-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Diffusion constants are compared with independent viscosity measurements.

📌 3 Key Takeaways

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Objective & Hypothesis:Ascorbic acid loaded polyvinylpyrrolidone tablets are prepared and ascorbic acid release profiles are monitored by the automatic continuous online monitoring of polymerization (ACOMP) system.
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Key Findings & Data:Kinetic rate constants for the dissolution and diffusion processes are calculated.
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Conclusion & Impact:Diffusion constants are compared with independent viscosity measurements.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Online monitoring · drug delivery systems · biomedical applications

Abstract

Ascorbic acid loaded polyvinylpyrrolidone tablets are prepared and ascorbic acid release profiles are monitored by the automatic continuous online monitoring of polymerization (ACOMP) system. Three different molecular weights of polymers are used in tablets. Parallel experiments are performed using powder samples. Drug release from tablets is investigated as zeroth and halfth order processes for the dissolution step and a first order process for the diffusion step. Powder samples are investigated on the basis of a first order diffusion model. Kinetic rate constants for the dissolution and diffusion processes are calculated. Release profiles are found to depend strongly on the molecular weights of the polymers. Higher molecular weights are found to slow down both the dissolution and the diffusion processes. Diffusion constants are compared with independent viscosity measurements.

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Cite This Article

GÜNGÖRDÜ, H. İ., AKKAYA, N. E., GİZ, A., GİZ, H. Ç. (2015). EFFECT OF POLYMERIC EXCIPIENT MOLECULAR WEIGHT ON DRUG RELEASE PROFILES INVESTIGATED BY ONLINE MONITORED CONTROLLED RELEASE STUDIES. Sigma Journal of Engineering and Natural Sciences, Cilt: 33 Sayı: 3, 407–416. https://ajindex.com/articles/897905

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