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Journals / Uluslararası Mühendislik Araştırma ve Geliştirme Dergisi / 2018 / Cilt: 10 - Sayı: 1

Making Adsorption of Effective Agents of Antidepressıon Drugs: Kinetıc and Isotherm

Antideprasan İlaçların Etken Maddelerinin Adsorpsiyonu: Kinetik ve İzotermi

Orhan BAYTAR
Pages
1–11
Publication Date
2017-01-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The adsorption kinetics of the drug substance were calculated for pseudo first order and pseudo second order kinetic models and it was determined to be the best pseudo second order kinetic model.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the adsorption of the active agent of venlafaxine and doxylamine antidepressant drugs was investigated by using the high surface area active carbon obtained in our previous study.
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Key Findings & Data:Langmuir isotherm was found as 8.764 and 10.764 for qmax venlafaxine and doxylamine substances, respectively.
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Conclusion & Impact:The adsorption kinetics of the drug substance were calculated for pseudo first order and pseudo second order kinetic models and it was determined to be the best pseudo second order kinetic model.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Antideprasan · ilaç etken maddesi · adsorpsiyon

Abstract

In this study, the adsorption of the active agent of venlafaxine and doxylamine antidepressant drugs was investigated by using the high surface area active carbon obtained in our previous study. The effects of initial pH of solution, initial concentration of solution and amount of activated carbon were examined in adsorption experiments. The adsorption equilibrium data were applied to the Langmuir and Freundlich isotherms and the best Langmuir isotherm was determined. Langmuir isotherm was found as 8.764 and 10.764 for qmax venlafaxine and doxylamine substances, respectively. The adsorption kinetics of the drug substance were calculated for pseudo first order and pseudo second order kinetic models and it was determined to be the best pseudo second order kinetic model.

Özet

Bu çalışmada bir önceki çalışmamız elde ettiğimiz yüksek yüzey alana sahip aktif karbon kullanılarak venlafaxine ve doxylamine antiderprasan ilaçların etken maddesinin adsorpsiyonu incelenmiştir. Adsorpsiyon çalışmalarında çözelti başlangıç pH, çözelti başlangıç konsantrasyonu ve aktif karbon miktarı parametrelerin etkisi incelenmiştir. Adsorpsiyonun denge verileri Langmuir ve freundlich izotermlerine uygulanmış ve en iyi Langmuir izotermine uyduğu belirlenmiştir. Langmuir izotermine qmax venlafaxine ve doxylamine maddeleri için sırasıyla 8.764 ve 10.764 mg/g olduğu tespit edilmiştir. İlaç etken maddelerinin adsorpsiyon kinetiği yalancı birinci derece ve yalancı ikinci derece kinetik modeller için hesaplanmış ve en iyi yalancı ikinci derece kinetik model olduğu belirlenmiştir.

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Cite This Article

BAYTAR, O. (2017). Making Adsorption of Effective Agents of Antidepressıon Drugs: Kinetıc and Isotherm. Uluslararası Mühendislik Araştırma ve Geliştirme Dergisi, Cilt: 10 - Sayı: 1, 1–11. https://ajindex.com/articles/889453

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