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Journals / Sağlık Bilimlerinde İleri Araştırmalar Dergisi / 2022 / Cilt: 5 - Sayı: 3

ASSOCIATION OF HLA-DQ POLYMORPHISMS WITH HEPATITIS B VIRUS INFECTION IN TURKISH POPULATION

TÜRKİYE POPÜLASYONUNDA HLA-DQ POLİMORFİZMLERİNİN HEPATİT B VİRÜS ENFEKSİYONU İLE İLİŞKİSİ

Bülent ÇAKAL
Muzaffer ARIKAN
Alp ATASOY
Bilger ÇAVUŞ
Mehveş PODA
Mesut BULAKÇI
Mine GÜLLÜOĞLU
Mehmet DEMİRCİ
Filiz AKYÜZ
Pages
186–192
Publication Date
2022-11-16
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: It has been suggested that the HLA-DQ rs9272105 AA genotype and the A allele are risk factors for both the persistence of HBV infection and the development of HBV-related liver damage.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Host genetic factors can affect the natural course of hepatitis B virus (HBV) infection and the risk of development and progression of HBV-related liver diseases.
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Key Findings & Data:The aim of this study is to evaluate the role of the HLA-DQ gene polymorphisms rs9272105, rs2856718 and rs9275572 with HBV natural clearance, viral load and the development of HBV associated liver injury.
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Conclusion & Impact:Conclusions: It has been suggested that the HLA-DQ rs9272105 AA genotype and the A allele are risk factors for both the persistence of HBV infection and the development of HBV-related liver damage.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hepatit B virüs · HLA-DQ · genetik polimorfizm

Abstract

Objective: Host genetic factors can affect the natural course of hepatitis B virus (HBV) infection and the risk of development and progression of HBV-related liver diseases. The aim of this study is to evaluate the role of the HLA-DQ gene polymorphisms rs9272105, rs2856718 and rs9275572 with HBV natural clearance, viral load and the development of HBV associated liver injury. Materials and Methods: The study included 150 patients with chronic hepatitis B (CHB) and 140 patients as the control group, 58 of whom had chronic hepatitis C (CHC) and 82 of whom had undergone a liver biopsy due to different clinical indications. The HLA-DQ gene rs9272105, rs2856718 and rs9275572 polymorphisms were genotypes in liver samples using the hybridization probe assay. Results: A difference was found between the HLA-DQ gene rs9272105, rs2856718 and rs9275572 genotype and allele frequencies of the patients with CHB and the control group (P<0,05). The HLA-DQ rs9272105 AA genotype and presence of A allele were associated with hepatitis B surface antigen (HBsAg) clearance and liver injury (p<0,05). In contrast, the HLA-DQ genes rs2856718 and rs9275572 were not associated with HBV clearance and patients’ histological outcomes, nor with patients’ viral load, including rs9272105. Conclusions: It has been suggested that the HLA-DQ rs9272105 AA genotype and the A allele are risk factors for both the persistence of HBV infection and the development of HBV-related liver damage.

Özet

Amaç Konak genetik faktörleri hepatit B virüs (HBV) enfeksiyonunun doğal seyri ve HBV ilişkili karaciğer hastalıklarının gelişme riski ile progresyonu üzerinde etkili olabilmektedir. Bu çalışmada HLA-DQ gen rs9272105, rs2856718 ve rs9275572 polimorfizmlerinin HBV doğal klirensi, viral yük ve HBV ile ilişkili karaciğer hasarı gelişimi ile ilişkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem Çalışmaya 150 kronik hepatit B (KHB) hastası ile kontrol grubu olarak 58’i kronik hepatit C (KHC) ve 82’si farklı klinik endikasyonlar nedeniyle karaciğer biyopsi işlemi gerçekleştirilen 140 hasta dâhil edildi. HLA-DQ rs9272105, rs2856718 ve rs9275572 genotip ve polimorfizmlerinin belirlenmesinde TaqMan SNP genotiplendirme yöntemi kullanıldı. Bulgular KHB’li ve kontrol grubundaki hastaların HLA-DQ gen rs9272105, rs2856718 ve rs9275572 genotip ve allel frekansları arasında farklılık tespit edildi (P<0,05). HLA-DQ rs9272105 AA genotip ve A allel varlığı, hepatit B yüzey antijen (Hepatitis B surface antigen; HBSAg) klirensi ve karaciğer hasarı ile ilişkiliydi (p<0,05). HLA-DQ gen rs2856718 ve rs9275572 ise HBV klirensi ve hastaların histolojik sonuçlarıyla ve ayrıca rs9272105 de dâhil hastaların viral yükleriyle ilişkili değildi. Sonuç HLA-DQ rs9272105 AA genotip ve A allel gerek HBV enfeksiyonunun kronikleşmesi gerekse HBV ilişkili karaciğer hasarının gelişmesi için risk faktördür.

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Cite This Article

ÇAKAL, B., ARIKAN, M., ATASOY, A., ÇAVUŞ, B., PODA, M., BULAKÇI, M., GÜLLÜOĞLU, M., DEMİRCİ, M., AKYÜZ, F. (2022). ASSOCIATION OF HLA-DQ POLYMORPHISMS WITH HEPATITIS B VIRUS INFECTION IN TURKISH POPULATION. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, Cilt: 5 - Sayı: 3, 186–192. https://ajindex.com/articles/888387

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