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Journals / İstanbul Journal of Pharmacy / 2020 / Cilt: 50 - Sayı: 2

Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone

Gamze ERGİN KIZILÇAY
Sıdıka ERTÜRK TOKER
Pages
95–102
Publication Date
2020-08-27
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Aims: In this study, simple, accurate and precise spectrophotometric methods were developed for the determination of five 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors in pure and pharmaceutical dosage forms.
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Key Findings & Data:The methods were based on the charge-transfer reaction of n-electron donor drugs with π-acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).
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Conclusion & Impact:Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:HMG-CoA reductase inhibitors · spectrophotometric determination · charge-transfer reaction

Abstract

Background and Aims: In this study, simple, accurate and precise spectrophotometric methods were developed for the determination of five 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors in pure and pharmaceutical dosage forms. Methods: In the developed methods, atorvastatin fluvastatin, pitavastatin, rosuvastatin and simvastatin were used in this class of drugs called statins. The methods were based on the charge-transfer reaction of n-electron donor drugs with π-acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). All variables such as temperature, time, reaction medium, amount of reagent were examined for optimal formation of complexes to be given by the drugs with DDQ and optimal conditions were determined. Results: The linearity ranges for atorvastatin, fluvastatin, pitavastatin, rosuvastatin and simvastatin were found to be 0.5-50, 1-6, 2.5-50, 5-25 and 5-50 μg/mL, respectively. Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms

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Cite This Article

KIZILÇAY, G. E., TOKER, S. E. (2020). Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone. İstanbul Journal of Pharmacy, Cilt: 50 - Sayı: 2, 95–102. https://ajindex.com/articles/88771

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