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Journals / İstanbul Journal of Pharmacy / 2020 / Cilt: 50 - Sayı: 2

Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis

Halil KARA
Kenan ULUALP
Pages
83–88
Publication Date
2020-08-27
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The mean hydroxyproline level was significantly lower in the Duraseal® groups than in the FG groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Aims: Anastomotic leaks represent a major complication of colorectal surgery.
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Key Findings & Data:Results: While the mean bursting pressure was statistically higher in groups treated with Duraseal® when compared to controls (p0.05).
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Conclusion & Impact:The mean hydroxyproline level was significantly lower in the Duraseal® groups than in the FG groups (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Duraseal · surgical anastomosis · fibrin glue

Abstract

Background and Aims: Anastomotic leaks represent a major complication of colorectal surgery. This study, involving a rat model of normal and ischemic colon anastomosis, aims to compare the effects of Duraseal® with those of Fibrin Glue (FG). Methods: Fifty adult male Wistar Albino rats were divided into six groups; normal colon anastomosis, ischemic colon anastomosis, FG on normal colon anastomosis, Duraseal® on normal colon anastomosis, FG on ischemic colon anastomosis, Duraseal ® on ischemic colon anastomosis. After scarification, bursting pressure were measured and samples were collected for histopathological examination and hydroxyproline assays. Results: While the mean bursting pressure was statistically higher in groups treated with Duraseal® when compared to controls (p0.05). The mean hydroxyproline level was significantly lower in the Duraseal® groups than in the FG groups (p

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Cite This Article

KARA, H., ULUALP, K. (2020). Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis. İstanbul Journal of Pharmacy, Cilt: 50 - Sayı: 2, 83–88. https://ajindex.com/articles/88769

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