SavedAdd your journal

Journals / Interdisciplinary Medical Journal / 2021 / Cilt: 12 - Sayı: 44

The Effect of Familial Mediterranean Fever Disease on The Cornea

Ailevi Akdeniz Ateşinin Korneaya Etkisi

Ahmet ELBEYLİ
Pages
226–230
Publication Date
2021-12-24
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Compared to healthy individuals, patients with FMF may have significant morphological changes in the structure of the cornea.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To investigate corneal structural in patients with Familial Mediterranean Fever (FMF).
📊
Key Findings & Data:Methods: This case-control study included 64 patients with FMF and, 49 age and gender similar healthy subjects without any eye disease.
💡
Conclusion & Impact:Conclusion: Compared to healthy individuals, patients with FMF may have significant morphological changes in the structure of the cornea.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ailevi Akdeniz Ateşi · Kornea · İnflamasyon

Abstract

Objective: To investigate corneal structural in patients with Familial Mediterranean Fever (FMF). Methods: This case-control study included 64 patients with FMF and, 49 age and gender similar healthy subjects without any eye disease. Endothelial cell density (ECD), the coefficient of variation in cell size (CV) and percentage of hexagonality were measured by non-contact specular microscopy, central corneal thickness (CCT) was measured by ultrasonic pachymetry. Results: The mean CCT value was 516.89± 32.23 μm in the study group and 545.12±24.56 μm in the control group. The mean ECD, CV, and percentage of hexagonality values were 3402.51±383.84 cells/mm², 26.72±4.55%, and 68.60±8.63%in the study group, respectively and 3339.46±322.60 cells/mm², 27.59± 5.23%, and 67.34± 9.38% in the control group, respectively. Of these parameters, the CCT values were statistically significantly different between the study and control groups (p = 0.011). Conclusion: Compared to healthy individuals, patients with FMF may have significant morphological changes in the structure of the cornea.

Özet

Amaç:Ailevi Akdeniz Ateşi (AAA) hastalarında korneal yapısal değişiklikleri araştırmak. Gereç ve Yöntem: Çalışmaya AAA hastası olan 64 kişi (çalışma grubu) ile herhangibir göz hastalığı olmayan, yaş ve cinsiyet uyumlu 49 kişi kontrol grubu olarak alındı. Santral kornea kalınlığı, endotel hücre sayısı (EHS), hücrelerin hegzagonalite yüzdesi(HEXA) ve varyasyon katsayısı (VK) ultrasonik pakimetre ile değerlendirildi. Bulgular: Çalışma grubunda, ortalama santral kornea kalınlığı(SKK) 516.89± 32.23 iken kontrol grubunda 545.12±24.56 olarak bulundu. Endotel hücre sayısı(EHS), hegzagonalite yüzdesi(HEXA) ve hücre varyasyon katsayısı(VK) sırasıyla 3402.51±383.84 cells/mm², 26.72±4.55%, and 68.60±8.63 % idi. Kontrol grubunda ise aynı parametreler 3339.46±322.60 cells/mm², 27.59± 5.23%, ve 67.34± 9.38% olarak bulundu. Bu parametrelerden santral kornea kalınlığı(CCT) ise iki grup arasında istatiksel olarak anlamlı farklı bulundu(p=0.011). Sonuç: Çalışma sonuçlarına göre AAA hastalarında, sağlıklı bireyler ile karşılaştırıldığında önemli korneal morfolojik-yapısal değişiklikler olabilir.

🔖

Cite This Article

ELBEYLİ, A. (2021). The Effect of Familial Mediterranean Fever Disease on The Cornea. Interdisciplinary Medical Journal, Cilt: 12 - Sayı: 44, 226–230. https://ajindex.com/articles/887560

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Sohar E, Gafni J, Pras M, Heller H. Familial Mediterranean fever: a survey of 470 cases and review of the literature. Am J Med 1967; 43:227-253. https://doi.org/10.1016/0002-9343(67)90167-2 The İnternational FMF Consortium: Ancient missense mutations in a new member of the RoRet gene family are likely to cause FMF. Cell 1997; 90: 797-807. https://doi.org/10.1016/s0092-8674(00)80539-5
  2. Mankan AK, Kubarenko A, Hornung V. Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation. Clin Exp Immunol. 2012;167:369–381. https://doi.org/10.1111/j.1365-2249.2011.04534.x
  3. Seshadri S, Duncan MD, Hart JM, Gavrilin MA, Wewers MD. Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release. J Immunol.2007; 179:1274–1281. https://doi.org/10.4049/jimmunol.179.2.1274
  4. Petrushkin H, Stanford M, Fortune F, Jawad AS. Clinical Review: Familial Mediterranean Fever-An Overview of Pathogenesis, Symptoms, Ocular Manifestations, and Treatment. Ocul Immunol Inflamm. 2016 Aug;24(4):422-30. https://doi.org/10.3109/09273948.2015.1010012
  5. Kosekahya P, Ucgul Atilgan C, Atilgan KG, Koc M, Tekin K, Caglayan M, et al. Increased Corneal Ectasia Risk in Patients with Familial Mediterranean Fever. Curr Eye Res. 2019;44(4):351-355. https://doi.org/10.1080/02713683.2018.1554150
  6. McCarey BE, Edelhauser HF, Lynn MJ. Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions. Cornea 2008;27:1-16 https://doi.org/10.1097/ICO.0b013e31815892da
  7. Doughty MJ, Müller A, Zaman ML. Assessment of the reliability of human corneal endothelial cell-density estimates using a noncontact specular microscope. Cornea 2000;19:148-158. https://doi.org/10.1097/00003226-200003000-00006
  8. Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1b production. Proc Natl Acad Sci U S A. 2006;103: 9982–9987. https://doi.org/10.1073/pnas.0602081103
  9. Sugioka K, Mishima H, Kodama A, Itahashi M, Fukuda M, Shimomura Y. Regulatory Mechanism of Collagen Degradation by Keratocytes and Corneal Inflammation: The Role of Urokinase-Type Plasminogen Activator. Cornea. 2016 Nov;35 Suppl 1:S59-S64. https://doi.org/10.1097/ICO.0000000000000995
  10. Kosker M, Arslan N, Alp MY, Itahashi M, Fukuda M, Shimomura Y. Association Between Kerato