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Journals / Journal of Experimental and Clinical Medicine / 2022 / Cilt: 39 - Sayı: 4

Effect of lead exposure during perinatal period on kidney of adult offspring in rat: A stereological study

Malihej SAGHEBRAY SHİRAZİ
Javad SADEGHİNEZHAD
Hassan MOROVVATİ
Sara SHOKRPOOR
Ehsan ROOMİANİ
Sareh NAJAF ASAADİ
Mahdi AGHABALAZADEH ASL
Sana GHOLİPOUR
Ali BAYAT
Pages
1120–1127
Publication Date
2022-10-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results showed a decrease in the volume and length of the DCT and also some pathological effects in experimental groups, in comparison with the control group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Lead is the most common toxic metal in nature, and its adverse effects on various organs, including the kidneys.
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Key Findings & Data:Group 1 (control) animals had access to normal drinking water plus 0.5 ml/liter of glacial acetic acid (as a lead acetate solvent) through the study.
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Conclusion & Impact:Results showed a decrease in the volume and length of the DCT and also some pathological effects in experimental groups, in comparison with the control group.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:kidney · lead · stereology

Abstract

Lead is the most common toxic metal in nature, and its adverse effects on various organs, including the kidneys. Kidney development is a complex process that is influenced by various environmental factors. Although lead toxicity can occur at any age, it is important in pregnant mothers and infants. Therefore, in this study, the effects of low dose lead administration on kidney offspring in rat model were investigated using stereology technique. The animals were randomly divided into in to five groups. Group 1 (control) animals had access to normal drinking water plus 0.5 ml/liter of glacial acetic acid (as a lead acetate solvent) through the study. Group 2 animals were administrated 0.2% of lead acetate in drinking water for 30 days before mating. Group 3 rats received drinking water with 0.2% of lead for 21 days during pregnancy. Group 4 animals received 0.2% of lead acetate in drinking water for 21 days during lactation. Group 5 animals were given 0.2 % lead acetate in drinking water during pre-pregnancy (30 days), pregnancy (21 days) and lactation (21 days) periods. The left kidney was removed from male offspring 60 days after birth. The volume of the kidney, cortex, medulla, proximal convoluted tubules (PCT) and distal convoluted tubules (DCT), as well as the length of PCT and DCT, were analyzed by means of stereology. Results showed a decrease in the volume and length of the DCT and also some pathological effects in experimental groups, in comparison with the control group. Due to the ameliorating effect of lead in perinatal period even in low doses on offspring kidneys, cautiousness is needed in this period.

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Cite This Article

SHİRAZİ, M. S., SADEGHİNEZHAD, J., MOROVVATİ, H., SHOKRPOOR, S., ROOMİANİ, E., ASAADİ, S. N., ASL, M. A., GHOLİPOUR, S., BAYAT, A. (2022). Effect of lead exposure during perinatal period on kidney of adult offspring in rat: A stereological study. Journal of Experimental and Clinical Medicine, Cilt: 39 - Sayı: 4, 1120–1127. https://ajindex.com/articles/886776

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