Journals / European Journal of Technique / 2022 / Cilt: 12 - Sayı: 2

SARS-CoV-2 Virus RNA Sequence Classification and Geographical Analysis with Convolutional Neural Networks Approach

Pages
182–189
Publication Date
2022-12-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our experimental results have revealed that now the detection of the geographic distribution of the virus with the CNN models might serve as an efficient method.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Covid-19 infection, which spread to the whole world in December 2019 and is still active, caused more than 250 thousand deaths in the world today.
📊
Key Findings & Data:In this study, RNA sequences belonging to the SARS-CoV-2 virus are transformed into gene motifs with two basic image processing algorithms and classified with the convolutional neural network (CNN) models.
💡
Conclusion & Impact:Our experimental results have revealed that now the detection of the geographic distribution of the virus with the CNN models might serve as an efficient method.
🔬Design:Modeling & Simulation
📍Scope:2019 Verileri
⚙️Variables:Deep Learning · Bioinformatics · Artificial Intelligence

Abstract

Covid-19 infection, which spread to the whole world in December 2019 and is still active, caused more than 250 thousand deaths in the world today. Researches on this subject have been focused on analyzing the genetic structure of the virus, developing vaccines, the course of the disease, and its source. In this study, RNA sequences belonging to the SARS-CoV-2 virus are transformed into gene motifs with two basic image processing algorithms and classified with the convolutional neural network (CNN) models. The CNN models achieved an average of 98% Area Under Curve(AUC) value was achieved in RNA sequences classified as Asia, Europe, America, and Oceania. The resulting artificial neural network model was used for phylogenetic analysis of the variant of the virus isolated in Turkey. The classification results reached were compared with gene alignment values in the GISAID database, where SARS-CoV-2 virus records are kept all over the world. Our experimental results have revealed that now the detection of the geographic distribution of the virus with the CNN models might serve as an efficient method.

🔖

Cite This Article

YAZAR, S. (2022). SARS-CoV-2 Virus RNA Sequence Classification and Geographical Analysis with Convolutional Neural Networks Approach. European Journal of Technique, Cilt: 12 - Sayı: 2, 182–189. https://ajindex.com/articles/885933

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. M. Wainberg, D. Merico, A. Delong, and B. J. Frey, "Deep learning in biomedicine," Nature Biotechnology, vol. 36, no. 9, pp. 829-838, 2018/10/01 2018
  2. Y. Lu, Y. Zhou, W. Qu, M. Deng, and C. Zhang, "A Lasso regression model for the construction of microRNA-target regulatory networks," Bioinformatics, vol. 27, no. 17, pp. 2406-2413, 2011
  3. D. Fioravanti et al., "Phylogenetic convolutional neural networks in metagenomics," BMC Bioinformatics, vol. 19, no. 2, p. 49, 2018/03/08 2018
  4. Y. Zhang, X. Liu, J. MacLeod, and J. Liu, "Discerning novel splice junctions derived from RNA-seq alignment: a deep learning approach," BMC Genomics, vol. 19, no. 1, p. 971, 2018/12/27 2018
  5. G. Eraslan, L. M. Simon, M. Mircea, N. S. Mueller, and F. J. Theis, "Single-cell RNA-seq denoising using a deep count autoencoder," Nature Communications, vol. 10, no. 1, p. 390, 2019/01/23 2019
  6. P. Danaee, R. Ghaeini, and D. A. Hendrix, "A DEEP LEARNING APPROACH FOR CANCER DETECTION AND RELEVANT GENE IDENTIFICATION," (in eng), Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, vol. 22, pp. 219-229, 2017
  7. L. L. M. Poon and M. Peiris, "Emergence of a novel human coronavirus threatening human health," Nature Medicine, vol. 26, no. 3, pp. 317-319, 2020/03/01 2020
  8. S. M. Smith and J. M. Brady, "SUSAN—A New Approach to Low Level Image Processing," International Journal of Computer Vision, vol. 23, no. 1, pp. 45-78, 1997/05/01 1997
  9. Y. Shu and J. McCauley, "GISAID: Global initiative on sharing all influenza data - from vision to reality," Euro Surveill, vol. 22, no. 13, Mar 30 2017
  10. E. L. Hatcher et al., "Virus Variation Resource–improved response to emergent viral outbreaks," Nucleic acids research, vol. 45, no. D1, pp. D482-D490, 2017
  11. W. R. Pearson and D. J. Lipman, "Improved tools for biological sequence comparison," (in eng), Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 8, pp. 2444-2448, 1988
  12. I. Miko and L. LeJeune, Essentials of Genetics. Cambridge, MA: NPG Education, 2009
  13. J. Bresenham, "A linear algorithm for incremental digital display of circular arcs," Communications of the ACM, vol. 20, no. 2, pp. 100-106, 1977
  14. R. Chokshi, D. Israni, and N. Chavda, "An efficient deconvolution technique by identification and estimation of blur," in 2016 IEEE International Conference on Recent Trends in Electronics, Information & Communication Technology (RTEICT), 2016, pp. 17-23