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Journals / Cumhuriyet Science Journal / 2022 / Cilt: 43 - Sayı: 4

Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives

Demokrat NUHA
Asaf Evrim EVREN
Zennure Şevval ÇİYANCI
Halide Edip TEMEL
Gülşen AKALIN ÇİFTÇİ
Leyla YURTTAŞ
Pages
584–589
Publication Date
2022-12-27
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

It was determined that the compounds exhibited inhibition of between 33.66–47.96 % against AChE and 13.03–63.29 % against BuChE at 80 µg/mL concentration.

📌 3 Key Takeaways

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Objective & Hypothesis:The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data were used to determine the structure of the compounds.
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Key Findings & Data:Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes.
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Conclusion & Impact:It was determined that the compounds exhibited inhibition of between 33.66–47.96 % against AChE and 13.03–63.29 % against BuChE at 80 µg/mL concentration.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:PET-RAFT polymerization · Grafting from method · Bioconjugation

Abstract

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data were used to determine the structure of the compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. It was determined that the compounds exhibited inhibition of between 33.66–47.96 % against AChE and 13.03–63.29 % against BuChE at 80 µg/mL concentration.

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Cite This Article

NUHA, D., EVREN, A. E., ÇİYANCI, Z. Ş., TEMEL, H. E., ÇİFTÇİ, G. A., YURTTAŞ, L. (2022). Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives. Cumhuriyet Science Journal, Cilt: 43 - Sayı: 4, 584–589. https://ajindex.com/articles/885446

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