Journals / Cukurova Medical Journal / 2023 / Cilt: 48 - Sayı: 1

Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling

Kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor pozitifliği: gebelik öncesi danışmanlığın önemi

Pages
278–282
Publication Date
2023-03-31
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders.
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Key Findings & Data:Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history.
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Conclusion & Impact:Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anti-Parietal Antikor · Cilt Bozukluğu · Kötü Obstetrik Öykü

Abstract

Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders. Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history. Patients were grouped into the control (women with skin disorders only, n=50) and study groups (women with skin disorders and APCA positivity, n=13). The study groups were compared in terms of demographic findings, BOI, and risk factors for placenta-related obstetric complications. Results: APCA (+) and APCA (–) groups showed no statistically significant difference in terms of demographic findings such as age, gravidity, parity, BOI, and the number of miscarriages.. We have demonstrated that 69.2% (9/13) of the APCA (+) cases have two or more skin diseases, while 34% of APCA (-) women have multiple skin diseases. There was a statistically significant difference between APCA (+) and APCA (–) groups in terms of the presence of single or multiple skin diseases (p=0.029). We could not demonstrate a statistically significant difference between APCA (+) and APCA (–) patients in terms of the presence of risk factors for obstetric complications such as immune system problems, MTHFR polymorphisms, hereditary thrombophilia, and diabetes mellitus type-2. Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.

Özet

Amaç: BU çalışmanın amacı kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor (APCA) pozitifliğinin anlamını göstermektir. Gereç ve Yöntem: Bu retrospektif kohort, deri hastalıkları ve kötü obstetrik geçmişi olan 63 kadından oluşuyordu. Hastalar kontrol (sadece deri hastalıkları olan kadınlar, n=50) ve çalışma grubu (deri hastalıkları ve APCA pozitifliği olan kadınlar, n=13) olarak gruplandırılmıştır. Çalışma ve kontrol grubu demografik bulgular, BOI ve plasentaya bağlı obstetrik komplikasyonlarla ilişkili risk faktörleri açısından karşılaştırıldı. Bulgular: APCA (+) ve APCA (–) grupları; yaş, gravida, parite, BOI ve düşük sayısı gibi demografik bulgular açısından istatistiksel olarak anlamlı farklılık göstermedi. APCA (+) vakaların %69,2'sinin (9/13) iki veya daha fazla deri hastalığına sahip olduğunu, ancak bu oranın APCA (-) olanlarda %34 bulunduğunu gösterdik. APCA (+) ve APCA (–) grupları arasında tekli ve çoklu deri hastalığı varlığı açısından istatistiksel olarak anlamlı fark vardı. APCA (+) ve APCA (-) hastalar arasında obstetrik komplikasyonlarla ilişkili risk faktörlerinin (bağışıklık sistemi sorunları, MTHFR polimorfizmleri, kalıtsal trombofili ve diyabetes mellitus tip-2 gibi) varlığı açısından istatistiksel olarak anlamlı bir farklılık gösteremedik. Sonuç: Obstetrik komplikasyonlar için risk faktörü olan APCA pozitifliğinin, gebelik öncesi danışma sırasında belirlenmesi, kötü obstetrik öykü ve dermatolojik sorunları olan hastalarda çoklu deri hastalıklarının önceden belirlenmesinde önemli rol oynayabilir.

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Cite This Article

BEKSAC, B., DONMEZ, H. G., CAGAN, M., BEKSAC, M. (2023). Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling. Cukurova Medical Journal, Cilt: 48 - Sayı: 1, 278–282. https://ajindex.com/articles/885400

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