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Journals / Cukurova Medical Journal / 2023 / Cilt: 48 - Sayı: 1

The relationship between dietary antioxidant capacity and serum oxidative stress index of hemodialysis patients

Hemodiyaliz hastalarında diyetin antioksidan kapasitesi ile serum oksidatif stres indeksi arasındaki ilişki

Hacer ALATAŞ
Mendane SAKA
Nurgül ARSLAN
Bülent YAPRAK
Önder OTLU
İrem PEMBEGÜL
Pages
72–83
Publication Date
2023-03-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the results of the study, it is recommended to monitor the food consumption status of hemodialysis patients in order to increase the dietary antioxidant capacity.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Oxidative stress increases in uremic conditions such as kidney failure and during hemodialysis.
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Key Findings & Data:Materials and Methods: In this study conducted with 82 individuals (41 patients and 41 controls).
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Conclusion & Impact:According to the results of the study, it is recommended to monitor the food consumption status of hemodialysis patients in order to increase the dietary antioxidant capacity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kronik böbrek yetmezliği · hemodiyaliz · diyet total antioksidan kapasitesi

Abstract

Purpose: Oxidative stress increases in uremic conditions such as kidney failure and during hemodialysis. In this study, it was aimed to examine the relationship between the total antioxidant capacity of the diet and the serum oxidative stress (sOSI) index in hemodialysis patients. Materials and Methods: In this study conducted with 82 individuals (41 patients and 41 controls). Demographic characteristics and anthropometric measurements of the individuals were taken by researchers. In order to determine the nutritional status of the individuals, 3-day food consumption records were taken and the total antioxidant capacity of the diet was calculated. Results: The mean age of the individuals participating in the study was found to be 54.01±2.24 years. Hemodialysis treatment mean for 4.8±3.12 years. While 41.46% of hemodialysis patients were moderately malnourished. Dietary Oxygen Radical Absorption Capacity (dORAC) (μmol) measurement result was found to be 2415.3±1073.45, 5468.4±2393.85 in the hemodialysis and control groups, respectively. In the multiple logistic regression analysis performed, the decrease in body mass index (OR 2.21 95% CI 1.050-2.317) and triceps skinfold thickness values (OR 3.22 95% CI 1.722-4.001) in hemodialysis patients led to an increase in the sOSI value. It has been observed that when dietary protein (OR 1.23 95% CI 1.003-3.189), vitamin C (OR 2.88 95% CI 1.004-3.106) and dTAC (OR 2.04 95% CI 1.967-2.001) increase, the sOSI value decreases in hemodialysis patients. Conclusion: There is a positive relationship between diet total antioxidant capacity and serum antioxidant level, and it was determined that the dietary antioxidant capacity of hemodialysis patients was significantly lower than that of healthy individuals. According to the results of the study, it is recommended to monitor the food consumption status of hemodialysis patients in order to increase the dietary antioxidant capacity.

Özet

Amaç: Oksidatif stres böbrek yetmezliği gibi üremik durumlarda ve hemodiyaliz sırasında artar. Bu çalışmada hemodiyaliz hastalarında diyetin toplam antioksidan kapasitesi ile serum oksidatif stres (sOSI) indeksi arasındaki ilişkinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışmaya 82 birey (41 hasta ve 41 kontrol) dahil edilmiştir. Bireylerin demografik özellikleri ve antropometrik ölçümleri araştırmacılar tarafından alınmıştır. Beslenme durumlarını belirlemek için 3 günlük besin tüketim kayıtları alınmış ve diyetin toplam antioksidan kapasitesi hesaplanmıştır. Bulgular: Çalışmaya katılan bireylerin yaş ortalaması 54,01±2,24 yıl olarak bulundu. Hemodiyaliz tedavisi süresi ortalama 4,8±3,12 yıldır. Hemodiyaliz hastalarının %41,46'sı orta derecede malnütrisyonluydu. Diyet oksijen radikal soğurma kapasitesi (dORAC) (μmol) ölçüm sonucu hemodiyaliz ve kontrol gruplarında sırasıyla 2415,3±1073,45, 5468,4±2393,85 olarak bulundu. Yapılan çoklu lojistik regresyon analizinde hemodiyaliz hastalarında beden kütle indeksi (OR 2.21 %95 CI 1.050-2.317) ve triseps deri kıvrım kalınlığı değerlerindeki (OR 3.22 %95 CI 1.722-4.001) azalma sOSI değerinde artışa neden olmuştur. Hemodiyaliz hastalarında diyetle alınan protein (OR 1.23 95% CI 1.003-3.189), C vitamini (OR 2.88 95% CI 1.004-3.106) ve dTAC (OR 2.04 95% CI 1.967-2.001) arttığında sOSI değeri düşmektedir. Sonuç: Diyet total antioksidan kapasitesi ile serum antioksidan düzeyi arasında pozitif bir ilişki vardır ve hemodiyaliz hastalarının diyet antioksidan kapasitesinin sağlıklı bireylere göre anlamlı derecede düşük olduğu belirlenmiştir. Çalışma sonuçlarına göre diyet antioksidan kapasitesinin artırılması için hemodiyaliz hastalarının besin tüketim durumlarının takibi önerilmektedir

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Cite This Article

ALATAŞ, H., SAKA, M., ARSLAN, N., YAPRAK, B., OTLU, Ö., PEMBEGÜL, İ. (2023). The relationship between dietary antioxidant capacity and serum oxidative stress index of hemodialysis patients. Cukurova Medical Journal, Cilt: 48 - Sayı: 1, 72–83. https://ajindex.com/articles/885376

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