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Journals / Artuklu International Journal of Health Sciences / 2023 / Cilt: 3 - Sayı: 1

The Efficacy of Iron and Piracetam in Breath Holding Spells and Levetiracetam in Anoxic Epileptic Seizures

Katılma Nöbetlerinde Demir ve Pirasetam ile Anoksik Epileptik Nöbetlerde Levetirasetamın Etkinliği

Nezir ÖZGÜN
Osman AKDENİZ
Muhittin ÇELİK
Hakan SARBAY
İzzettin TOKTAŞ
Pages
18–23
Publication Date
2023-04-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Levetiracetam seems to be considerably effective in patients developing anoxic epileptic seizures after BHS.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: In this study, the patients diagnosed with breath holding spell (BHS) or anoxic epileptic seizures and initiated at least one out of iron or piracetam or levetiracetam therapies were evaluated.
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Key Findings & Data:Material and Methods: We retrospectively evaluated 194 BHS patients.
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Conclusion & Impact:Levetiracetam seems to be considerably effective in patients developing anoxic epileptic seizures after BHS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Katılma nöbeti · Anoksik epileptik nöbet · Tedavi

Abstract

Introduction: In this study, the patients diagnosed with breath holding spell (BHS) or anoxic epileptic seizures and initiated at least one out of iron or piracetam or levetiracetam therapies were evaluated. Material and Methods: We retrospectively evaluated 194 BHS patients. Iron therapy was initiated in case of iron deficiency anemia or case of ferritin values under 12 ng/dl even if there was no anemia. The patients having no iron deficiency anemia, low ferritin and anoxic epileptic seizures were administered piracetam and the patients diagnosed with anoxic epileptic seizures were administered levetiracetam. Results: One hundred and eight patients (55.7%) were male. The mean age was 21.39±12.78 months. Iron therapy was initiated in 87 patients, piracetam to 96, and levetiracetam in 11 patients. Seizure numbers were manifestly decreased in all groups by the end of the first month after treatment concerning pretreatment levels (p<0.05). Conclusions: We determined that the spells were reduced or completely stopped in all groups. Levetiracetam seems to be considerably effective in patients developing anoxic epileptic seizures after BHS.

Özet

Giriş: Bu çalışmada, katılma nöbeti veya anoksik epileptik nöbet tanısı alan ve demir, pirasetam veya levetirasetam tedavilerinden en az biri başlanan hastalarda, ilaçların nöbetleri azaltma etkinliği değerlendirilmiştir. Materyal and Metot: Çalışma kriterlerini karşılayan 194 hastanın dosyaları geriye dönük olarak incelenmiştir. Demir eksikliği anemisi olan veya anemi olmasa bile ferritin değeri 12 ng/dl altında olan hastalara demir tedavisi başlanmıştı. Anemi, düşük ferritin ve anoksik epileptik nöbeti olmayan hastalara pirasetam, anoksik epileptik nöbeti olanlara levetirasetam başlanmıştı. Bulgular: Hastaların 108’i (% 55.7) erkekti. Ortalama yaş 21.39±12.78 aydı. 87 hastaya demir tedavisi, 96 hastaya pirasetam ve 11 hastaya levetirasetam başlanmıştı. Tedavi başlandıktan bir ay sonraki değerlendirmede tüm gruplarda nöbet sayısı belirgin azalmıştı (p<0.05). Sonuç: Tüm gruplarda nöbet sayısının azaldığını veya tam durduğunu saptadık. Levetirasetam katılma nöbeti sonrası gelişen anoksik epileptik nöbetlerde oldukça etkili gibi görünmektedir.

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Cite This Article

ÖZGÜN, N., AKDENİZ, O., ÇELİK, M., SARBAY, H., TOKTAŞ, İ. (2023). The Efficacy of Iron and Piracetam in Breath Holding Spells and Levetiracetam in Anoxic Epileptic Seizures. Artuklu International Journal of Health Sciences, Cilt: 3 - Sayı: 1, 18–23. https://ajindex.com/articles/884158

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References (14)

  1. Leung AKC, Leung AAM, Wong AHC, Hon KL. Breath-Holding Spells in Pediatrics: A Narrative Review of the Current Evidence. Curr Pediatr Rev. 2019;15(1):22-29.
  2. Abbaskhanian A, Ehteshami S, Sajjadi S, Rezai MS. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial. Iran J Child Neurol. 2012;6(4):9–15. DiMario FJ Jr SM. Family pedigree analysis of children with severe breath-holding spells. J Pediatr. 1997;130(4):647–51.
  3. Azab SFA, Siam AG, Saleh SH, Elshafei MM, Elsaeed WF, Arafa MA, et al. Novel findings in breath-holding spells: A cross-sectional study. Med (United States). 2015;94(28):1–7.
  4. Vurucu S, Paksu MS, Karaoglu A, Oz O, Yaman H, Gulgun M, et al. Breath-holding spells may be associated with maturational delay in myelination of brain stem. J Clin Neurophysiol. 2014;19(1):99-101.
  5. Saad K, Farghaly HS, Badry R, Othman HAK. Selenium and antioxidant levels decreased in blood of children with breath-holding spells. J Child Neurol. 2014;29(10):1339–43.
  6. Sawires H, Botrous O. Double-blind, placebo-controlled trial on the effect of piracetam on breath-holding spells. Eur J Pediatr. 2012;171(7):1063–7.
  7. Leung AKC, Leung AAM, Wong AHC, Hon KL. Breath-Holding Spells in Pediatrics: A Narrative Review of the Current Evidence. Curr Pediatr Rev. 2018;15(1):22–9. Stephenson JBP. Febrile convulsions and reflex anoxic seizures. 4th Edition,
  8. Rose FC. London, UK: Pitman. 1998:244-52.
  9. Kuhle S, Tiefenthaler M, Seidl R, Hauser E. Prolonged generalized epileptic seizures triggered by breath-holding spells. Pediatr Neurol. 2000;23(3):271–3.
  10. Jain R, Omanakuttan D, Singh A, Jajoo M. Effect of iron supplementation in children with breath holding spells. J Paediatr Child Health. 2017;53(8):749–53.
  11. Azam M, Bhatti N, Shahab N. Piracetam in severe breath holding spells. Int J Psychiatry Med. 2008;38(2):195–201.
  12. Mattie-Luksic M, Javornisky G DF. Assessment of Stress in Mothers of Children with Severe Breath-Holding Spells. Pediatrics. 2000;106(1):1–5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/?term=Assessment+of+stress+in+mothers+of+children+with+severe+breath-holding+spells
  13. Stephenson JBP, Breningstall G, Steer C, Kirkpatrick M, Horrocks I, Nechay A, et al. Anoxic-epileptic seizures: Home video recordings of epileptic seizures induced by syncopes. Epileptic Disord. 2004;6(1):15–9. Francis J. DiMario. Prospective study of children with cyanotic and pallid breath-holding spells. Pediatrics. 2001;107(2):265-9.
  14. Khurana D, Valencia I, Kr