Journals / Journal of Contemporary Medicine / 2023 / Cilt: 13 - Sayı: 1

The Effect of Exercise on Serum Resistin and Leptin Values in Rats Fed with a High Fat Diet

Yüksek Yağlı Diyetle Beslenen Ratlarda Egzersizin Serum Resistin ve Leptin Değerlerine Etkisi

Pages
82–85
Publication Date
2023-01-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: It has been determined that feeding with a high-fat diet causes an increase in serum resistin and leptin levels, and exercise provides a significant decrease in resistin values, but is not effective in leptin levels.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This study was performed to investigate the effect of exercise on serum resistin and leptin values in rats fed with a high-fat diet.
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Key Findings & Data:Material and Method: 24 Wistar albino male rats were used in the study.
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Conclusion & Impact:Conclusion: It has been determined that feeding with a high-fat diet causes an increase in serum resistin and leptin levels, and exercise provides a significant decrease in resistin values, but is not effective in leptin levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Resistin · Leptin · Exercise

Abstract

Aim: This study was performed to investigate the effect of exercise on serum resistin and leptin values in rats fed with a high-fat diet. Material and Method: 24 Wistar albino male rats were used in the study. They were randomly divided into 4 groups, with 6 rats in each group. The groups were determined as the control group (C), exercise group (E), high-fat diet (HFD) group, and high-fat diet + exercise (HFDE) Group. Results: When the findings obtained in this study were evaluated statistically, it was determined that the resistin values were similar in the C, E and HFDE groups, and higher in the HFD group compared to the other groups. It was observed that resistin value increased with high-fat diet and decreased with exercise. When evaluated in terms of leptin levels, the C and E groups showed similarity, while the HFD and HFDE groups showed similarity with each other. Although exercise decreased the leptin level, which was highly increased with a high-fat diet, it was not statistically significant. Conclusion: It has been determined that feeding with a high-fat diet causes an increase in serum resistin and leptin levels, and exercise provides a significant decrease in resistin values, but is not effective in leptin levels.

Özet

Amaç: Bu çalışma, yüksek yağlı diyetle beslenen ratlarda egzersizin serum resistin ve leptin değerlerine nasıl bir etkisinin olacağını araştırmak için yapıldı. Gereç ve Yöntem: Çalışmada 24 adet Wistar albino ırkı erkek rat kullanıldı. Her grupta 6 adet rat olacak şekilde rastgele 4 gruba ayrıldı. Gruplar kontrol grubu (K), egzersiz grubu (E), yüksek yağlı diyet (YYD) grubu ve yüksek yağlı diyet + egzersiz (YYDE) Grubu olarak belirlendi. Bulgular: Yapılan bu araştırmada elde edilen bulgular istatiksel olarak değerlendirildiğinde K, E ve YYDE gruplarında resistin değerlerinin benzer olduğu, YYD grubunda ise diğer gruplara göre yüksek olduğu tespit edilmiştir. Yüksek yağlı diyet ile artan resistin değerinin egzersiz ile düştüğü görülmüştür. Leptin seviyeleri açısından değerlendirildiğinde K ve E grubu benzerlik gösterirken, YYD ve YYDE grupları da birbiri ile benzerlik göstermektedir. Yüksek yağlı diyet ile oldukça artan leptin seviyesini egzersiz bir miktar düşürse de, istatistiksel açıdan anlamlı bulunmamıştır. Sonuç: Yüksek yağlı diyet ile beslenmenin serum resistin ve leptin düzeylerinde artışa sebep olduğu, egzersizin resistin değerlerinde anlamlı bir düşüş sağladığı fakat leptin düzeylerinde etkili olmadığı tespit edilmiştir.

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Cite This Article

BULDUK, B., GÜNBATAR, N. (2023). The Effect of Exercise on Serum Resistin and Leptin Values in Rats Fed with a High Fat Diet. Journal of Contemporary Medicine, Cilt: 13 - Sayı: 1, 82–85. https://ajindex.com/articles/880724

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References (14)

  1. Mosby TT, Cosgrove M, Sarkardei S, et al. Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens. Anticancer research 2012; 32(10): 4171-4192
  2. Toumilehto J, Lindström J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350
  3. Swinburn BA, Caterson I, Seidell JC, et al. Diet, nutrition and the prevention of excess weight gain and obesity. Public health nutrition 2004; 7(1a): 123-146
  4. Kodama S, Tanaka S, Heianza Y, et al. Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis. Diabetes care 2013; 36(2): 471-479
  5. Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001; 409(6818): 307-312
  6. Ukkola O. Resistin-a mediator of obesity-associated insulin resistance or an innocent bystander?. European journal of endocrinology 2002;147(5): 571-574
  7. Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379(6566):632-635
  8. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. Journal of leukocyte biology 2000;68(4): 437-446
  9. Keleş V, Büyükgüzel K, Büyükgüzel E. Leptin ve Metabolik Düzenlenmedeki Rolü. Türkiye Diyabet ve Obezite Dergisi, 2018; 2(1): 17-22
  10. Yaşar S, Günbatar N, Yüksek S, et al. Effect of exercise on erythrocyte osmotic fragility in high fat diet fed rats during intermittent fasting. Eastern Journal Of Medicine, 2017; 22(4): 176
  11. Günbatar, N, Bayıroğlu, F. The Effect of a Highly Saturated Fat Diet and Intermittent Fasting Diet on Experimental Colon Cancer Development and Some Serum Inflammation Markers in Rats, 1 Adiponectin and Lipid Metabolism. Van Veterinary Journal, 2015; 26 (3): 123-127
  12. Pagano C, Marin O, Calcagno A, et al. Increased serum resistin in adults with prader-willi syndrome is related to obesity and not to insulin resistance. The Journal of Clinical Endocrinology & Metabolism 2005; 90(7): 4335-4340
  13. Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends in endocrinology & Metabolism 2002; 13(1): 18-23
  14. Eminler AT, Aygun C, Konduk T, et al. The relationship between resistin and ghrelin levels with fibrosis in nonalcoholic fatty liver disease. Journal of research in medical sciences: the official journal of Isfahan