Results: In Group 1, decrease in body temperatures was significant from 4th to 12th hours (p
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Aim: Hypothermia is a rare complication of antipsychotic drugs but serious outcomes including death may result.
📊
Key Findings & Data:Materials and methods: 63 intensive care patients who needed sedative treatment due to agitation were divided into two groups as Group 1 (n = 30) with temperatures ≤ 38°C, and Group 2 (n = 33) with temperatures > 38°C according to baseline body temperatures.
💡
Conclusion & Impact:Results: In Group 1, decrease in body temperatures was significant from 4th to 12th hours (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:adverse drug reaction · body temperature changes · chlorpromazine
Abstract
Aim: Hypothermia is a rare complication of antipsychotic drugs but serious outcomes including death may result. In this study, we aimed to investigate body temperature alterations in acute phase of chlorpromazine treatment, the relationship of inflammatory indicators and risk factors for hypothermic effect in intensive care unit (ICU) patients. Materials and methods: 63 intensive care patients who needed sedative treatment due to agitation were divided into two groups as Group 1 (n = 30) with temperatures ≤ 38°C, and Group 2 (n = 33) with temperatures > 38°C according to baseline body temperatures. Also, recurrent measurements for 12 hours were made at specific intervals following 25 mg intravenous chlorpromazine. Results: In Group 1, decrease in body temperatures was significant from 4th to 12th hours (p
İLBAN, Ö., ZORA, M. E., AKÇAY, B. D., ÇELİK, J. B., ÇİÇEKCİ, F., BAŞ, M. A., DUMAN, A. (2022). The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients. Genel Tıp Dergisi, Cilt: 32 - Sayı: 6, 658–665. https://ajindex.com/articles/879100
Boschi G, Launay N, Rips R. Neuroleptic-induced hypothermia in mice: lack of evidence for a central mechanism. J Pharmac. 1987;90:745–51
Ginawi OT. Possible involvement of opioid receptors in moclobemide-induced hypothermia in mice. Pharmacol Res. 2003;48:237–40
Asanami S, Shimono K. Species-level differences between mice and rats in regards to micronucleus induction with the hypothermia-inducing drug haloperidol. Mutat Res. 2009;676:102-5
Van Marum RJ, Wegewijs MA, Loonen AJ, Beers E. Hypothermia following antipsychotic drug use. Eur J Clin Pharmacol. 2007;63:627-631
Gocke E. Review of the genotoxic properties of chlorpromazine and related phenothiazines. Mutat Res. 1996;366:9-21
Lopez-Munoz F, Alamo C, Cuenca E, et al. History of the discovery and clinical introduction of chlorpromazine. Ann Clin Psychiatry. 2005;17:113-135
Adams F. Neuropsychiatric evaluation and treatment of delirium in the critically ill cancer patient. Cancer Bulletin. 1984;36:156-160
Coppolo DP, May JJ. Self-extubations: A 12 month experience. Chest. 1990;98:165-169
Robinson BR, Mueller EW, Henson K, et al. An analgesia-delirium-sedation protocol for critically ill trauma patients reduces ventilator days and hospital length of stay. J Trauma. 2008;65:517-26
Adams F. Emergency intravenous sedation of the delirious medically ill patient. J Clin Psychiatry. 1988;49:22-26
Marks W. Physical restraints in the practice of medicine: Current concepts. Arch Intern Med. 1992;152:2203-6
Sakkat A, Alquraini M, Aljazeeri J, et al. Temperature control in critically ill patients with fever: A meta-analysis of randomized controlled trials. J Crit Care. 2021;61:89-95
Dippel DW, van Breda EJ, van Gemert HM, et al. Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. Stroke. 2001;32:1607-12
Gramish JA, Kopp BJ, Patanwala AE. Effect of amantadine on agitation in critically ill patients with traumatic brain injury. Clin Neuropharmacol. 2017;40:212-216
Gélinas C. Pain assessment in the critically ill adult: Recent evidence and new trends. Intensive Crit Care Nurs. 2016;34:1-11
Severgnini P, Pelosi P, Contino E, et al. Accuracy of critical care pain observation tool and behavioral pain scale to assess pain in critically ill conscious and unconscious patients: prospective, observational study. J Intensive Care. 2016;4:68