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Journals / Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / 2022 / Cilt: 10 - Sayı: 2

Association between serum netrin-1 level and obesity-related markers in obese subjects

Obez bireylerde serum netrin-1 düzeyi ve obezite ile ilgili belirteçler arasındaki ilişki

Çiğdem AYDIN ACAR
Niyazi AYDIN
Suray PEHLİVANOĞLU
Mehmet KÖK
Pages
108–115
Publication Date
2022-08-26
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The median value was 844.0 pg/mL in the control group and 338 pg/mL in the obese group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Netrins are important signaling proteins that guide both neural and vascular development.
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Key Findings & Data:Netrin-1 regulates many physiological processes such as cell proliferation, adhesion and migration.
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Conclusion & Impact:The median value was 844.0 pg/mL in the control group and 338 pg/mL in the obese group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Obezite · Netrin-1 · ELISA

Abstract

Netrins are important signaling proteins that guide both neural and vascular development. Netrin-1 regulates many physiological processes such as cell proliferation, adhesion and migration. The aim of this study was to determine the association between serum netrin-1 level and biochemical parameters in obese subjects. Serum samples were collected from obese (n=15) and control (n=30) subjects. The serum netrin-1 levels were evaluated by ELISA. Variable data were compared by Mann Whitney U test and correlation was estimated by Spearman correlation analyses. The level of circulating netrin-1 protein was determined to be significantly lower in obese group compared to controls. The median value was 844.0 pg/mL in the control group and 338 pg/mL in the obese group (p

Özet

Netrinler, hem nöral hem de vasküler gelişime rehberlik eden önemli sinyal proteinleridir. Netrin-1 hücre çoğalması, yapışması ve göçü gibi birçok fizyolojik süreci düzenler. Bu çalışmanın amacı obez bireylerde serum netrin-1 düzeyi ile biyokimyasal parametreler arasındaki ilişkiyi belirlemektir. Obez (n=15) ve kontrol (n=30) bireylerden serum örnekleri alındı. Serum netrin-1 seviyeleri ELISA ile değerlendirildi. Değişken veriler Mann Whitney U testi ile karşılaştırıldı ve korelasyon Spearman korelasyon analizleri ile belirlendi. Obez grupta serumda netrin-1 protein seviyesinin kontrollere göre anlamlı derecede düşük olduğu belirlendi. Ortanca değer kontrol grubunda 844,0 pg/mL ve obez grupta 338 pg/mL idi (p

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Cite This Article

ACAR, Ç. A., AYDIN, N., PEHLİVANOĞLU, S., KÖK, M. (2022). Association between serum netrin-1 level and obesity-related markers in obese subjects. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, Cilt: 10 - Sayı: 2, 108–115. https://ajindex.com/articles/875437

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