Journals / SDÜ Tıp Fakültesi Dergisi / 2022 / Cilt: 29 - Sayı: 4

EVALUATION OF INFLAMMATION-RELATED HEMOGRAM PARAMETERS AS A USEFUL MARKER IN PAPILLARY THYROID CARCINOMA

PAPİLLER TİROİD KARSİNOMUNDA YARARLI BİR BELİRTEÇ OLARAK İNFLAMASYONLA İLİŞKİLİ HEMOGRAM PARAMETRELERİNİN DEĞERLENDİRİLMESİ

Pages
611–618
Publication Date
2022-12-27
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

White blood cells (WBC), neutrophils and lymphocytes were lower in 3rd group than 4th group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective Inflammation-related hemogram parameters have recently started to be defined as a useful marker in cancer patients.
📊
Key Findings & Data:Material and Method The 287 patients’ data were analyzed in study.
💡
Conclusion & Impact:White blood cells (WBC), neutrophils and lymphocytes were lower in 3rd group than 4th group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:papiller tiroid kanseri · WDT-UMP · foliküler adenom

Abstract

Objective Inflammation-related hemogram parameters have recently started to be defined as a useful marker in cancer patients. In this study, we aimed to comparison of hemogram parameters in papillary thyroid cancer (PTC) patients, well differentiated thyroid tumor of uncertain malignant potential (WDT-UMP) and follicular adenoma (FA). Material and Method The 287 patients’ data were analyzed in study. Study subjects were divided into 5 different groups. 1st group: control, 2nd group: FA, 3rd group: WDT-UMP, 4th group: non-metastatic PTC, 5th group: metastatic PTC. We evaluated the preoperative blood tests. Results The average age was 50 (37-59). The mean TSH value was 1.2 (0.5-2.2) μIU/mL. The mean size of the lesion detected in the total thyroidectomy material was 1.7 (1.0-3.0) cm. White blood cells (WBC), neutrophils and lymphocytes were lower in 3rd group than 4th group (p

Özet

Amaç İnflamasyona bağlı hemogram parametreleri son zamanlarda kanser hastalarında faydalı bir belirteç olarak tanımlanmaya başlamıştır. Bu çalışmada, papiller tiroid kanserli (PTC), malignite potansiyeli belirsiz iyi diferansiye tiroid tümörü ve foliküler adenomlu (FA) hastalarda hemogram parametrelerinin karşılaştırılması amaçlandı. Gereç ve Yöntem Çalışmada 287 hastanın verileri analiz edildi. Çalışma popülasyonu 5 farklı gruba ayrıldı. 1. Grup: kontrol, 2. grup: FA, 3. grup: WDT-UMP, 4. grup: metastatik olmayan PTC, 5. grup: metastatik PTC. Ameliyat öncesi yapılan kan testlerini değerlendirdik. Bulgular Ortalama yaş 50 (37-59) idi. Ortalama TSH değeri 1.2 (0.5-2.2) μIU/mL idi. Total tiroidektomi materyalinde saptanan lezyonun ortalama boyutu 1.7 (1.0-3.0) cm idi. Grup 3'te beyaz kan hücreleri (WBC), nötrofiller ve lenfositler grup 4'e göre daha düşüktü (p

🔖

Cite This Article

SÖZEN, M., CANTÜRK, Z., SELEK, A., ÇETİNASLAN, B., SEVİNÇ, B., GEZER, E., KÖKSALAN, D. (2022). EVALUATION OF INFLAMMATION-RELATED HEMOGRAM PARAMETERS AS A USEFUL MARKER IN PAPILLARY THYROID CARCINOMA. SDÜ Tıp Fakültesi Dergisi, Cilt: 29 - Sayı: 4, 611–618. https://ajindex.com/articles/870559

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Hsu DS, Kim MK, Balakumaran BS, et al. Immune signatures predict prognosis in localized cancer. Cancer Investigation. 2010;28(7):765-73
  2. Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow? Vol. 357, Lancet. Elsevier Limited; 2001. p. 539–45
  3. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-7
  4. Ari A, Gunver F. Comparison of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in patients with thyroiditis and papillary tumors. Journal of International Medical Research. 2019;47(5):2077-83
  5. Yokota M, Katoh H, Nishimiya H, et al. Lymphocyte-monocyte ratio significantly predicts recurrence in papillary thyroid cancer. Journal of Surgical Research. 2020;246:535-43
  6. Çölkesen F. Pankreas kanserli hastalarda hematolojik parametrelerin (mean platelet volume, nötrofil/lenfosit oranı, trombosit/ lenfosit oranı, eozinofil ve lenfosit sayısı) prognoz - tedavi takibinde kullanılabilirliklerinin araştırılması. Selçuk Üniversitesi, Yayımlanmış Uzm tezi, Kony. 2015
  7. Lang BH, Ng CP, Au KB, et al. Does preoperative neutrophil lymphocyte ratio predict risk of recurrence and occult central nodal metastasis in papillary thyroid carcinoma?. World journal of surgery. 2014:2605-12
  8. Lian L, Xia YY, Zhou C, et al. Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer. Oncology letters. 2015;10(6):3419-24
  9. Hussein O, Abdelwahab K, Hamdy O, et al. Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area. Journal of the Egyptian National Cancer Institute. 2020;32(1):1-4
  10. Li MM, Yue CX, Fu S, et al. Platelet volume is reduced in metastasing breast cancer: Blood profiles reveal significant shifts. Cancer Management and Research. 2019;11:9067
  11. Lai X, Xia Y, Zhang B, et al. A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk. Oncotarget. 2017;8(37):62414
  12. Wang X, Cui MM, Xu Y, et al. Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer. Oncotarget. 2017;8(40):68115
  13. Feng J, Wang Y, Shan G, et al. Clinical and prognostic value of neutrophil-lymphocyte ratio for patients with thyroid cancer: A meta-analysis. Medicine. 2020;99(20)
  14. Al-Kindi SG, Refaat M, Jayyousi A, et al. Red cell distribution width is associated with all-cause and cardiovascular mortality in patients with diabetes. BioMed research international. 2017;2017
  15. Sit M, Aktas G, Ozer