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Journals / Journal of Apitherapy and Nature / 2022 / Cilt: 5 - Sayı: 2

Klotho Protein and Type 2 Diabetes Mellitus

Klotho Proteini ve Tip 2 Diabetes Mellitus

Eda DOKUMACIOĞLU
Hatice ISKENDER
Pages
133–146
Publication Date
2022-12-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, a decrease in KL levels plays a role in type 2 DM and the development of nephropathy and vascular diseases caused by type 2 DM.

📌 3 Key Takeaways

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Objective & Hypothesis:Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes of death in western societies.
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Key Findings & Data:The frequency of DM increases with age, and the severity of events such as oxidative stress and inflammation increases in patients diagnosed with DM.
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Conclusion & Impact:In conclusion, a decrease in KL levels plays a role in type 2 DM and the development of nephropathy and vascular diseases caused by type 2 DM.
🔬Design:Review & Systematic Survey
📍Scope:2002-2020 Verileri
⚙️Variables:inflamasyon · Type 2 Diabetes mellitus · Klotho

Abstract

Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes of death in western societies. In the development of the disease, the underlying pathophysiological mechanisms are complex and multifactorial. The frequency of DM increases with age, and the severity of events such as oxidative stress and inflammation increases in patients diagnosed with DM. The Klotho (KL) protein, defined as a new anti-aging protein as a result of the studies on aging mechanisms and it has an important functions on glucose homeostasis and insulin secretion. In this review study, the relationship between KL protein and DM is explained by compiling the information in the articles published in PubMed indexed journals between 2002-2020. In conclusion, a decrease in KL levels plays a role in type 2 DM and the development of nephropathy and vascular diseases caused by type 2 DM.

Özet

Diabetes Mellitus (DM), birçok ülke tarafından epidemik bir hastalık olarak kabul edilmekte ve batı toplumlarında en önde gelen ölüm nedenlerinden biri olarak gösterilmektedir. Hastalığın gelişiminde altta yatan patofizyolojik mekanizmalar kompleks ve multifaktöriyeldir. DM sıklığı yaş ile artmakta ve bununla birlikte oksidatif stres, inflamasyon gibi olayların şiddeti de DM tanılı hastalarda artmaktadır. Yaşlanma mekanizmaları üzerinde yapılan araştırmalar sonucu yeni bir anti-aging protein olarak tanımlanan klotho (KL) proteini glukoz homeostazı ve insulin salgılanmasında önemli fonksiyonlara sahiptir. Bu derleme çalışmasında, 2002-2020 yılları arasında PubMed'de taranan dergilerde yayınlanan makalelerdeki bilgiler derlenerek KL proteini ile DM arasındaki ilişki anlatılmıştır. Sonuç olarak, KL düzeylerindeki azalma tip 2 DM ve buna bağlı olarak gelişen nefropati ve vasküler hastalıklarda önemli rol oynar.

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Cite This Article

DOKUMACIOĞLU, E., ISKENDER, H. (2022). Klotho Protein and Type 2 Diabetes Mellitus. Journal of Apitherapy and Nature, Cilt: 5 - Sayı: 2, 133–146. https://ajindex.com/articles/869147

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