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Journals / DÜSTAD Dünya Sağlık ve Tabiat Bilimleri Dergisi / 2022 / Cilt: 5 - Sayı: 2

Evaluation of NSE and GFAP level and hemorrhage volume in terms of prognosis in head trauma:A prospective controlled study.

Elif ÇELİKEL
Ahmet Burak ERDEM
Selçuk PARLAK
Çiğdem YÜCEL
Esra ÇIVGIN
Turan TURHAN
Cemil KAVALCI
Evvah KARAKILIÇ
Berkin KARAPINARLI
Pages
47–54
Publication Date
2022-12-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Intracranial bleeding can be interpreted by looking at the levels of these biomarkers.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The diagnosis process and follow-up of patients who come to the emergency department with head trauma are important for physicians.
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Key Findings & Data:We examined the usability of biomarkers released with increased volume due to intracranial hemorrhage in emergency services.
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Conclusion & Impact:Intracranial bleeding can be interpreted by looking at the levels of these biomarkers.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Head trauma · intracranial · hemorrage volume

Özet

Objectives: The diagnosis process and follow-up of patients who come to the emergency department with head trauma are important for physicians. We examined the usability of biomarkers released with increased volume due to intracranial hemorrhage in emergency services. Methods: 120 cases admitted to our hospital with blunt head trauma between 2017-1018 were included.GCS, blood NSE and GFAB levels, radiological bleeding volume, and patient outcomes were analyzed. Result: When we analyzed NSE and GFAP levels, GCS and bleeding volume, we found a statistically significant slight, negative correlation. We interpreted that when GCS is calculated low, NSE and GFAP increase and this increases the suspicion of intracranial hemorrhage clinically. Conclusion: NSE and GFAP levels are good in predicting intracranial bleeding. Intracranial bleeding can be interpreted by looking at the levels of these biomarkers.

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Cite This Article

ÇELİKEL, E., ERDEM, A. B., PARLAK, S., YÜCEL, Ç., ÇIVGIN, E., TURHAN, T., KAVALCI, C., KARAKILIÇ, E., KARAPINARLI, B. (2022). Evaluation of NSE and GFAP level and hemorrhage volume in terms of prognosis in head trauma:A prospective controlled study.. DÜSTAD Dünya Sağlık ve Tabiat Bilimleri Dergisi, Cilt: 5 - Sayı: 2, 47–54. https://ajindex.com/articles/867740

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References (6)

  1. Taylor CA, Bell JM, Breiding MJ, et al. Traumatic Brain İnjury-Related Emergency Depart-ment visits, hospitalizations, and deaths-United states 2007 and 2013. Center for disease con-trol and prevention. Morbidity and mortality weekly report. Surveillance summaries/Vol. 66/No.9, March 2017 2) Thelin E, Nimer FA, Frostell A, Zettenberg H, Blennow et al. A serum protein biomarker panel ımproves outcome prediction in human traumatic brain injury. Journal of Neurotrauma 36:2850-2862 (October 5,2019). DOI:10.1089/neu.2019.6375 3) Teasdale G, Maas A, Lecky F, et al. The Glasgow Coma Scale at 40 years: standing the test of time. Lancet Neurol 2014
  2. 844–54 4) Fanygersh V, Passero M. Estimating Radiation Risk from Computed Tomography Scanning. Lung (2009) 187:143–148. DOI 10.1007/s00408-009-9143-9 5) Bazarina J, Biberthaler P, Welch RD et. al. Serum GFAP and UCH-L1 for prediction of ab-sence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. www.thelancet.com/neurology Published online July 24, 2018 http://dx.doi.org/10.1016/S1474-4422(18)30231-X 6) Zetterberg H,Smith DH, Blennow KH. Biomarkers of mild traumatic brain injury in cerebro-spinal fluid and blood Nat Rev Neurol. 2013 April
  3. 9(4):201-210. Doi:10.1038/nneurol.2013.9. 7) Papa L, Robinson G,Oli M et al. Use of biomarkers for diagnosis and management of trau-matic brain injury patients. Expert Opin. Med. Diagn. (2008) 2(8):937-945 8) Mehta T, Fayyaz M, Giler GE et al. Current Trends in Biomarkers for Traumatic Brain Injury. Open Access J Neurol Neurosurg. 2020
  4. 12(4):86-94. 9) Vos PE, Lamer KJB, Hendricks JCM et al. Glial and neuronal proteins in serum predict out-come after severe traumatic brain injury. NEUROLOGY 2004
  5. 1303–1310 10) Nylen K, Öst M, Csajbok LZ et al. Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome. Journal of the Neurological Sciences 240 (2006) 85 – 91 11) Bazarina J, Biberthaler P, Welch RD et. al. Serum GFAP and UCH-L1 for prediction of ab-sence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. www.thelancet.com/neurology Published online July 24, 2018 http://dx.doi.org/10.1016/S1474-4422(18)30231-X 12) Aydın I, Algın A, Poyraz MK et al. Diagnostic value of Glial fibrillary asidic protein and S100B serum levels in emergeny medicine patients with traumatic versus non traumatic hem-orrhage. Nigerian journal of clinical practice.2018
  6. Vol:21(12).p:1645-1650 13) Duda İ, Wiorek,