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Journals / Sakarya Tıp Dergisi / 2026 / Volume: 15 Issue: 1

High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis

Yüksek Snail ekspresyonu Kolorektal Kanser Kökenli Karaciğer Metaztaslarında Rezeksiyon Sonrası Nüksü Yansıtır

Ahmet KARAMUSTAFAOĞLU
Secil AK AKSOY
Berrin TUNCA
Melis ERÇELİK
Çağla TEKİN
Nesrin UĞRAŞ
Ömer YERCİ
Fuat AKSOY
Ekrem KAYA
Pages
672–679
Publication Date
2022-12-28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC).
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Key Findings & Data:Materials and Methods: In the study, 85 patients were evaluated.
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Conclusion & Impact:Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Metastazektomi · metastatik karaciğer kanserleri · Epitelyal-Mezenkimal Tranzisyon

Abstract

Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers. The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs. Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR. Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p

Özet

Amaç: Cerrahi tedavi, primer kolorektal kanserden (KRK) gelişen karaciğer metastazları için etkili tedavi yöntemlerinden biridir. Bununla birlikte metastazektomi sonrası nüks bu kanserlerdeki en büyük problemdir. Mevcut çalışmada, primer KRK’lardan gelişen karaciğer metastazlarında Epitelyal-Mezenkimal Tranzisyon (EMT)’nin metastazektomi sonrası nüks gelişimindeki rolünün incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmada, 85 hasta, 12 normal kolon, 8 normal karaciğer dokusu değerlendirildi. Hastalara ait arşiv materyali tümör ve normal dokularından RNA izolasyonları yapıldı. qRT-PCR kullanılarak 7 farklı EMT belirtecinin ekspresyon profili incelendi. Bulgular: Seksen beş KRK’nın %24.7 (n=21)’sinde karaciğere metastazı gelişti. Karaciğer metastazı belirlenen hastaların %42.3’ünde (n=9) metastazektomi sonrası nüks gözlendi. Primer KRK’dan mKK gelişiminde EMT belirteçlerinden TWIST ve SNAIL ekspresyonlarında istatistiksel olarak anlamlı artış belirlendi (p

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Cite This Article

KARAMUSTAFAOĞLU, A., AKSOY, S. A., TUNCA, B., ERÇELİK, M., TEKİN, Ç., UĞRAŞ, N., YERCİ, Ö., AKSOY, F., KAYA, E. (2022). High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. Sakarya Tıp Dergisi, Volume: 15 Issue: 1, 672–679. https://ajindex.com/articles/862863

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