SavedAdd your journal

Journals / Mustafa Kemal Üniversitesi Tıp Dergisi / 2022 / Cilt: 13 - Sayı: 47

The analysis of anal cytology positivity in women with pathological cervical cytology

Patolojik servikal sitolojili kadınlardaki anal sitoloji pozitifliğinin analizi

Mehmet Esat DUYMUŞ
Zeynep BAYRAMOĞLU
Hulya AYİK
Yusuf Murat BAG
Pages
425–430
Publication Date
2022-12-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The use of AC for early diagnosis of risky anal intraepithelial lesions (such as a screening tool) may be considered for this group of patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Cervical cytology (CC) is a routine screening method used to reduce cervical cancer.
📊
Key Findings & Data:The patients with normal CC were excluded, finally 87 participants were included.
💡
Conclusion & Impact:The use of AC for early diagnosis of risky anal intraepithelial lesions (such as a screening tool) may be considered for this group of patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Servikal sitoloji · anal sitoloji · human papillomavirus

Abstract

Objective: Cervical cytology (CC) is a routine screening method used to reduce cervical cancer. Although anal cancer and cervical cancer have similar etiological factors the opinion about the anal cancer screening program is unclear. We aimed to determine the features of women with abnormal anal cytology (AC) who had screened via CC for cervical neoplasia. Method: Two hundred and five females’ CC results were investigated. The patients with normal CC were excluded, finally 87 participants were included. The demographics, medical, sexual, and reproductive features, CC and AC results were analyzed. Results: The study group had a mean age of 40.77 ± 9.50 years. AC was pathological in six patients (6.9%). Four of these (66.7%) were high-grade squamous intraepithelial lesions (HSIL) and two (33.3%) were low-grade squamous intraepithelial lesions (LSIL). The CC results of these patients were all HSIL, all of them were human papillomavirus (HPV) positive, with the most common type being 16 (83.3%). Conclusion: Women with HSIL in CC (especially with concomitant HPV) may be riskier for AC positivity. The others are most likely to have negative AC results. The use of AC for early diagnosis of risky anal intraepithelial lesions (such as a screening tool) may be considered for this group of patients.

Özet

Amaç: Servikal sitoloji (SS) serviks kanserini azaltmak için kullanılan rutin bir tarama yöntemidir. Anal kanser ve serviks kanseri benzer etiyolojik faktörlere sahip olsa da anal kanser tarama programı hakkındaki görüş net değildir. Bizim bu çalışma ile amacımız; SS ile servikal neoplazi taraması yapılan kadınlardan anormal anal sitoloji (AS)’ye sahip olanlarının özelliklerini belirlemektir. Yöntem: Toplam 205 kadın hastanın SS sonuçları incelendi. Normal SS’li hastalar dışlandı ve sonuçta 87 katılımcı çalışmaya dahil edildi. Demografik özellikleri, tıbbi, cinsel verileri ile reproduktif özellikleri analiz edildi. Bulgular: Çalışma grubunun yaş ortalaması 40.77 ± 9.50 idi. AS 6 hasta (%6.9)’da patolojikti ve bunlardan 4 (%66.7)’ü yüksek dereceli skuamöz intraepitelyal lezyon (HSIL), 2 (%33.3)’si düşük dereceli skuamöz intraepitelyal lezyon (LSIL) idi. Bu hastaların SS sonuçları HSIL’di ve hepsinde human papillomavirus (HPV) pozitifti. En sık görülen tipi HPV 16 idi. Sonuç: SS sonucu HSIL çıkan kadınlarda (özellikle eşlik eden HPV varlığında) AS pozitifliği daha riskli olabilir. Diğerlerinin ise AS sonuçlarının negatif çıkması muhtemeldir. AS kullanımı bu hasta grubu için anal intraepitelyal lezyonların erken teşhisinde (bir tarama aracı gibi) kullanılabilir.

🔖

Cite This Article

DUYMUŞ, M. E., BAYRAMOĞLU, Z., AYİK, H., BAG, Y. M. (2022). The analysis of anal cytology positivity in women with pathological cervical cytology. Mustafa Kemal Üniversitesi Tıp Dergisi, Cilt: 13 - Sayı: 47, 425–430. https://ajindex.com/articles/862109

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Shiels MS, Kreimer AR, Coghill AE, Darragh TM, Devesa SS. Anal Cancer Incidence in the United States, 1977-2011: Distinct Patterns by Histology and Behavior. Cancer Epidemiol Biomarkers Prev 2015;24(10):1548–56. https://doi. org/10.1158/1055-9965.EPI-15-0044. Palefsky JM. Anal human papillomavirus infection and anal cancer in HIV-positive individuals: an emerging problem. AIDS 1994;8(3):283-95. https://doi.org/10.1097/00002030-199403000-00001.
  2. Tseng HF, Morgenstern H, Mack TM, Peters RK. Risk factors for anal cancer: results of a population-based case–control study. Cancer Causes Control 2003;14(9):837-46. https://doi.org/10.1023/b:caco.0000003837.10664.7f.
  3. Moscicki AB, Schiffman M, Kjaer S, Villa LL. Updating the natural history of HPV and anogenital cancer. Vaccine 2006;24:S3/42–5 https://doi.org/10.1016/j.vaccine.2006.06.018.
  4. Valari O, Koliopoulos G, Karakitsos P, Valasoulis G, Founta C, Godevenos G, et al. Human papillomavirus DNA and mRNA positivity of the anal canal in women with lower genital tract HPV lesions, Predictors and Clinical Implications. Gynecol Oncol 2011;122(3):505-8. https://doi.org/10.1016/j. ygyno.2011.05.033. Joseph DA, Miller JW, Wu X, Chen VW, Morris CR, Goodman MT, et al. Understanding the burden of human papillomavirus associated anal cancers in the US. Cancer 2008;113(S10):2892-900. https://doi.org/10.1002/cncr.23744.
  5. Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, et al. Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 2004;101(2):270-80. https://doi.org/10.1002/cncr.20365.
  6. Frisch M, Glimelius B, Van den Brule AJ, Wohlfahrt J, Meijer CJ, Walboomers JM, et al. Sexually transmitted infection as a cause of anal cancer. N Engl J Med 1997;337(19):1350-8. https://doi.org/10.1056/NEJM199711063371904.
  7. Holly EA, Ralston ML, Darragh TM, Greenblatt RM, Jay N, Palefsky JM. Prevalence and risk factors for anal squamous intraepithelial lesions in women. J Natl Cancer Inst 2001;93(11):843-9. https://doi.org/10.1093/jnci/93.11.843.
  8. Do Socorro NM, Jacyntho CM, Eleutério JJr, Giraldo PC, Gonçalves AK. Abnormal anal cytology risk in women with known genital squamous intraepithelial lesion. Braz J Infect Dis 2016;20(3):294-7. https://doi.org/10.1016/j.bjid.2016.01.008.
  9. Williams AB, Darragh TM, Vranizan K, Ochia C, Moss AR, Palefsky JM. Anal and cervical human papillomavirus infection and risk of anal and cervical epithelial abnormalities in human immunodeficiency virus-infected wo