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Journals / Avrupa Bilim ve Teknoloji Dergisi / 2022 / Sayı: 38

The Effect of Lithium Toxicity on the Goldfish (Carassius auratus) Brain

Lityum Toksisitesinin Japon Balığı (Carassius auratus) Beynine Etkisi

Aslı ÇİLİNGİR YELTEKİN
Sama EL-TEKRETİ
Pages
435–439
Publication Date
2022-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, the enzymes catalase (CAT), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GSH-Px) in the Carassius auratus brain were shown to be altered by lithium chloride (LiCl).

📌 3 Key Takeaways

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Objective & Hypothesis:Although lithium is widely used as a standard in decreasing episodes of depression and mania, for its long-term stabilization and efficacy in reducing suicide risk, its use has recently declined due to side effects and the associated toxicity burden.
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Key Findings & Data:The spectrophotometric approach was used to investigate the effects of a lithium dosage (50 mg/L) in Carassius auratus at various periods (24 h, 48 h, 72 h, and 96).
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Conclusion & Impact:As a result, the enzymes catalase (CAT), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GSH-Px) in the Carassius auratus brain were shown to be altered by lithium chloride (LiCl).
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:toksite · lithuum · SOD

Abstract

Although lithium is widely used as a standard in decreasing episodes of depression and mania, for its long-term stabilization and efficacy in reducing suicide risk, its use has recently declined due to side effects and the associated toxicity burden. We did this study with the Carassius auratus fish as a model to learn about the adverse effects and toxicity of lithium on the brain. The spectrophotometric approach was used to investigate the effects of a lithium dosage (50 mg/L) in Carassius auratus at various periods (24 h, 48 h, 72 h, and 96). As a result, the enzymes catalase (CAT), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GSH-Px) in the Carassius auratus brain were shown to be altered by lithium chloride (LiCl).

Özet

Lityum, depresyon ve mani ataklarını azaltmada yaygın olarak standart olarak kullanılmasına rağmen, uzun vadeli stabilizasyonu ve intihar riskini azaltmadaki etkinliği nedeniyle, kullanımı yan etkiler ve ilişkili toksisite yükü nedeniyle son zamanlarda azalmıştır. Bu çalışmayı, lityumun beyin üzerindeki olumsuz etkileri ve toksisitesini öğrenmek için model olarak Carassius auratus balığı ile yaptık. Lityum dozajının (50 mg/L) Carassius auratus'taki etkilerini çeşitli periyotlarda (24 saat, 48 saat, 72 saat ve 96) araştırmak için spektrofotometrik yaklaşım kullanıldı. Sonuç olarak Carassius auratus beynindeki Katalaz (CAT), Süperoksit Dismutaz (SOD) ve Glutatyon Peroksidaz (GSH-Px) enzimlerinin lityum klorür (LiCl) tarafından değiştirildiği gösterildi.

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Cite This Article

YELTEKİN, A. Ç., EL-TEKRETİ, S. (2022). The Effect of Lithium Toxicity on the Goldfish (Carassius auratus) Brain. Avrupa Bilim ve Teknoloji Dergisi, Sayı: 38, 435–439. https://ajindex.com/articles/857478

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References (12)

  1. Aebi, H. (1984). [13] Catalase in vitro. In Methods in enzymology (Vol. 105, pp. 121-126). Academic press.‏ Ahmad, I., Hamid, T., Fatima, M., Chand, H. S., Jain, S. K., Athar, M., & Raisuddin, S. (2000). Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposure. Biochimica et Biophysica Acta (BBA)-General Subjects, 1523(1), 37-48.‏
  2. Ansari, T. M., Marr, I. L., & Tariq, N. (2004). Heavy metals in marine pollution perspective-a mini review. Journal of Applied Sciences, 4(1), 1-20.‏
  3. Anusuya, L., & Hemalatha, O. (2014). Effect of 2, 4-D pesticide on fish physiology and its antioxidant stress. World Journal of Fish and marine Sciences, 6(1), 98-100.‏
  4. Aral, H., & Vecchio-Sadus, A. (2008). Toxicity of lithium to humans and the environment—a literature review. Ecotoxicology and environmental safety, 70(3), 349-356.‏
  5. Bhalla, P., Garg, M. L., & Dhawan, D. K. (2010). Protective role of lithium during aluminium-induced neurotoxicity. Neurochemistry international, 56(2), 256-262.‏
  6. Braunbeck, T., Hauck, C. R., Scholz, S., & Segner, H. (1995). Mixed function oxygenases in cultured fish cells: contributions of in vitro studies to the understanding of MFO induction. Zeitschrift für angewandte Zoologie, 81, 55-72.‏
  7. Bury, N. R., Walker, P. A., & Glover, C. N. (2003). Nutritive metal uptake in teleost fish. Journal of experimental biology, 206(1), 11-23.‏
  8. Chaudhary, G., & Gupta, Y. K. (2001). Lithium does not synergize the peripheral action of cholinomimetics as seen in the central nervous system. Life Sciences, 68(18), 2115-2121.‏
  9. De Boer, J. D., Stronck, C. J. N., Traag, W. A., & Van der Meer, J. (1993). Non-ortho and mono-ortho substituted chlorobiphenyls and chlorinated dibenzo-p-dioxins and dibenzofurans in marine and freshwater fish and shellfish from the Netherlands. Chemosphere, 26(10), 1823-1842.‏
  10. De Roos, N. M., de Vries, J. H., & Katan, M. B. (2001). Serum lithium as a compliance marker for food and supplement intake. The American journal of clinical nutrition, 73(1), 75-79.‏
  11. Dimitrova, M. S., Tishinova, V., & Velcheva, V. (1994). Combined effect of zinc and lead on the hepatic superoxide dismutase-catalase system in carp (Cyprinus carpio). Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 108(1), 43-46.‏
  12. Farombi, E. O., Ajimoko, Y. R., & Adelowo, O. A. (2008). Effect of butachlor on antioxidant enzyme status and lipid peroxidation in fresh water African c