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Journals / OPUS Toplum Araştırmaları Dergisi / 2022 / Cilt: 5 - Sayı: 3

Effect of Intravenous Lipid (SMOFLIPID®) Use along in Vitro Fertilization (IVF) Treatment in Women with Failed IVF Cycles Despite Good Quality Embryo Transfer

KALİTELİ EMBRİYO TRANSFERİNE RAĞMEN BAŞARISIZ IVF SİKLUSU OLAN KADINLARDA İN VİTRO FERTİLİZASYON (IVF) TEDAVİSİ BOYUNCA İV LİPİD (SMOFLIPID®) KULLANIMININ ETKİSİ: VAKA KONTROL ÇALIŞMASI

Bertan AKAR
Ozan DOĞAN
Emre KÖLE
Eray ÇALIŞKAN
Pages
115–119
Publication Date
2022-10-15
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further prospective studies are needed to suggest the routine use of intralipid in patients with RIF.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Since recurrent implantation failure (RIF) is a challenging fact, effects of different therapeutic immunomodulatory agents are being investigated to overcome this problem.
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Key Findings & Data:Methods: 116 of the participants who received only the short antagonist protocol allocated in the control group, whereas 106 patients were in intralipid group by additionally receiving intravenous lipid (SMOFlipid®).
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Conclusion & Impact:Further prospective studies are needed to suggest the routine use of intralipid in patients with RIF.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:in vitro fertilizasyon · İntravenöz Lipid Emülsiyonları · Embriyo İmplantasyonları

Abstract

Objectives: Since recurrent implantation failure (RIF) is a challenging fact, effects of different therapeutic immunomodulatory agents are being investigated to overcome this problem. This study aimed to evaluate the effect of intralipid on pregnancy outcomes of IVF patients with RIF. Methods: 116 of the participants who received only the short antagonist protocol allocated in the control group, whereas 106 patients were in intralipid group by additionally receiving intravenous lipid (SMOFlipid®). Intralipid was given on the day of embryo transfer, on the day of positive pregnancy test and continued weekly until the tenth week of pregnancy. Implantation rate, biochemical pregnancy rate, clinical pregnancy rate and live birth rate were evaluated. Results: The positive pregnancy test, clinical pregnancy rate and live birth rate were statistically significantly higher (p0.05). Conclusions: This study revealed that intralipid therapy has better pregnancy outcomes in patients with RIF compared to patients undergo standard IVF protocol only. Further prospective studies are needed to suggest the routine use of intralipid in patients with RIF.

Özet

Amaç: Tekrarlayan implantasyon başarısızlığı (RIF) zorlu bir gerçek olduğundan, bu sorunun üstesinden gelmek için farklı terapötik immünomodülatör ajanların etkileri araştırılmaktadır. Bu çalışma, intralipidin RIF'li IVF hastalarının gebelik sonuçları üzerindeki etkisini değerlendirmeyi amaçlamıştır. Yöntemler: Katılımcıların 116'sı sadece kısa antagonist protokolünü alan kontrol grubuna, 106'sı ise intravenöz lipid (SMOFlipid®) verilerek intralipid grubunda yer aldı. İntralipid, embriyo transferinin olduğu gün, pozitif gebelik testinin olduğu gün verildi ve gebeliğin onuncu haftasına kadar haftalık olarak devam edildi. İmplantasyon oranı, biyokimyasal gebelik oranı, klinik gebelik oranı ve canlı doğum oranı değerlendirildi. Bulgular: Pozitif gebelik testi, klinik gebelik oranı ve canlı doğum oranı İntralipid grubunda istatistiksel olarak anlamlıydı (p0.05). Sonuçlar: Bu çalışma, intralipid tedavisinin, sadece standart IVF protokolü uygulanan hastalara kıyasla RIF'li hastalarda daha iyi gebelik sonuçlarına sahip olduğunu ortaya koymuştur. RIF'li hastalarda intralipidin rutin kullanımını önermek için daha ileri prospektif çalışmalara ihtiyaç vardır.

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Cite This Article

AKAR, B., DOĞAN, O., KÖLE, E., ÇALIŞKAN, E. (2022). Effect of Intravenous Lipid (SMOFLIPID®) Use along in Vitro Fertilization (IVF) Treatment in Women with Failed IVF Cycles Despite Good Quality Embryo Transfer. OPUS Toplum Araştırmaları Dergisi, Cilt: 5 - Sayı: 3, 115–119. https://ajindex.com/articles/856415

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