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Journals / Archives of Current Medical Research / 2022 / Cilt: 3 - Sayı: 1

Predictive role of NLR, SII, and PLR in COVID-19 patient mortality and disease severity

Ayşegül İnci SEZEN
Kadriye KART YAŞAR
Pages
43–50
Publication Date
2022-01-31
DOI
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Mortality was found to be statistically significant in patients with a CCI score of 2 or more and in patients with high CRP, NLR, PLR, and SII values at the time of admission (p<0.05) in the multivariate analysis.Conclusions: It was found that the most important factor affecting the severity of the disease was advanced age and high comorbidities, and a high NLR value.

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Objective & Hypothesis:Background: In this study, it was aimed to evaluate the factors affecting the prognosis and mortality of patients hospitalized for coronavirus disease 2019 (COVID-19).Methods: Patients hospitalized with COVID-19 infection between March and November 2020 were examined retrospectively.
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Key Findings & Data:The Systemic Immune-Inflammation Index (SII), platelet lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) values were evaluated for their effect on prognosis.Results: Of the 1013 patients included in the study, 204 (20.1%) had a severe infection.
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Conclusion & Impact:Mortality was found to be statistically significant in patients with a CCI score of 2 or more and in patients with high CRP, NLR, PLR, and SII values at the time of admission (p<0.05) in the multivariate analysis.Conclusions: It was found that the most important factor affecting the severity of the disease was advanced age and high comorbidities, and a high NLR value.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:COVID-19 · Mortality · Prognosis

Abstract

Background: In this study, it was aimed to evaluate the factors affecting the prognosis and mortality of patients hospitalized for coronavirus disease 2019 (COVID-19).Methods: Patients hospitalized with COVID-19 infection between March and November 2020 were examined retrospectively. The Systemic Immune-Inflammation Index (SII), platelet lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) values were evaluated for their effect on prognosis.Results: Of the 1013 patients included in the study, 204 (20.1%) had a severe infection. In the multivariate analysis, it was determined that the prognosis was significantly worse in patients who were >65 years of age, had a Charlson Comorbidity Index (CCI) score of >2, and had a high NLR rate. The C-reactive protein (CRP), PLR, SII values were detected as insignificant variables. Mortality was found to be statistically significant in patients with a CCI score of 2 or more and in patients with high CRP, NLR, PLR, and SII values at the time of admission (p<0.05) in the multivariate analysis.Conclusions: It was found that the most important factor affecting the severity of the disease was advanced age and high comorbidities, and a high NLR value. The most important prognostic factors affecting mortality were high levels of comorbidities, and high NLR, PLR, SII, and CRP values.

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Cite This Article

SEZEN, A. İ., YAŞAR, K. K. (2022). Predictive role of NLR, SII, and PLR in COVID-19 patient mortality and disease severity. Archives of Current Medical Research, Cilt: 3 - Sayı: 1, 43–50. https://ajindex.com/articles/850283

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