Journals / Klinik Tıp Pediatri Dergisi / 2017 / Cilt: 9 - Sayı: 2

In Allergic Diseases Mouse, Rat Models

Alerjik Hastalıklarda Fare, Sıçan Modelleri

Pages
186–193
Publication Date
2017-03-15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Yet, in this compiled article, mouse and rat models were emphasized for theyare ethical, their production and growing environments are easily standardizable andthey are more feasible economically.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:AbstractDuring the past few years, the increasing prevalence of allergies has brought about a search for new techniques of diagnosis and treatment.
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Key Findings & Data:Animal models of allergies play a major role in understanding the pathogenesis at immunological, physiological and histopatological levels as well as elaborating on the existing treatmentmethods.
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Conclusion & Impact:Yet, in this compiled article, mouse and rat models were emphasized for theyare ethical, their production and growing environments are easily standardizable andthey are more feasible economically.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Astım · Alerjik rinit · Atopik dermatit

Abstract

AbstractDuring the past few years, the increasing prevalence of allergies has brought about a search for new techniques of diagnosis and treatment. Animal models of allergies play a major role in understanding the pathogenesis at immunological, physiological and histopatological levels as well as elaborating on the existing treatmentmethods. It is indispensable to know the anatomic, physiological and biological characteristics of the laboratory animals used in biomedical research in order to obtainrepeatable and reliable outcomes in the animal models imitating the situation in humans. From this aspect, a variety of animals can be utilized to model allergic illnes-ses. Yet, in this compiled article, mouse and rat models were emphasized for theyare ethical, their production and growing environments are easily standardizable andthey are more feasible economically.

Özet

ÖzSon yıllarda alerjik hastalıkların görülme sıklığının artması tanı ve tedavi sürecin-de arayışları da beraberinde getirmiştir. Alerjik hastalıkların hayvan modelleri, im-munolojik, fizyolojik ve histopatolojik düzeyde patogenezi anlayabilmek, korunmave tedavide mevcut bilgilere yenilerini ekleyebilmek adına ciddi katkılarda bulun-maktadır. Biyomedikal araştırmalar için kullanılacak olan laboratuvar hayvanı türü-ne ait anatomik, fizyolojik ve biyolojik özelliklerin bilinmesi, insandaki hastalık sü-recine benzeyen modellerin oluşturulmasında, güvenilir ve tekrarlanabilir sonuçlarelde edilmesinde önemli bir basamaktır. Bu açıdan bakıldığında alerjik hastalıkla-rın laboratuvar hayvanı modelleri için çok çeşitli hayvan türleri kullanılabilir. An-cak bu derleme makalede; etik açıdan kabul edilebilir, üretim, yetiştirme ve barın-dırma ortamları daha kolay standardize edilebilir, ekonomik açıdan ulaşılabilir ol-ması nedeniyle fare ve sıçan modelleri üzerinde durulmuştur.

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Cite This Article

KARAMAN, D. D. M. (2017). In Allergic Diseases Mouse, Rat Models. Klinik Tıp Pediatri Dergisi, Cilt: 9 - Sayı: 2, 186–193. https://ajindex.com/articles/838438

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References (17)

  1. Kaynaklar 1.Wahn U. What drives the allergic march. Allergy. 2000
  2. 55(7): 591-9. 2.Wang X. A new vision of definition, commentary, and unders-tanding in clinical and translational medicine. Clin Transl Med.2012
  3. DOI: 10.1186/2001-1326-1-5 3.Hau J. Animal Models. In handbook of laboratory animalscience. Hau J, Van Hoosier GL Eds. Vol 2. CRS Press, Den-ver, 2003 4.Tanaka H, Masuda T, Tokuoka S et al. The effect of allergen-induced airway inflammation on airway remodeling in a mu-rine model of allergic asthma. Inflamm Res. 2001
  4. 616–24. 5.Elias J. The relationship between asthma and COPD: lessonsfrom transgenic mice. Chest. 2004
  5. 111–6. 6.Preface. The Welfare of Laboratory Animals, Kaliste E, ed.Springer: The Netherlands
  6. 2007, IX-X. 7.Özdemir C, Akdis M, Akdis CA. T cell response to allergens.Chem Immunol Allergy. 2010
  7. Karaman M. Alerjik Hastalıklarda Laboratuvar Hayvanı Mo-delleri. Turkiye Klinikleri J Pediatr Sci. 2014
  8. 10(2): 123-30. 9.Epstein MM. Are mouse models of allergic asthma useful for tes-ting novel therapeutics? Exp Toxicol Pathol. 2006
  9. Leigh R, Ellis R, Wattie J, Southam DS, De Hoogh M, Gaul-die J et al. Dysfunction and remodeling of the mouse airwaypersist after resolution of acute allergen-induced airway in-flammation. Am J Respir Cell Mol Biol. 2002
  10. 526–35. 11.Mims JW. Asthma: definitions and pathophysiology. Int Fo-rum Allergy Rhinol. 2015
  11. 5(1):2-6. 12.Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergyin the development of asthma. Nature. 1999
  12. 402(6760): 12-7. 13.Kips JC, Anderson GP, Fredberg JJ, Herz U, Inman MD, Jor-dana M, et al. Murine models of asthma. Eur Respir J. 2003
  13. 22(2): 374-82. 14.Temelkovski J, Hogan SP, Shepherd DP, Foster PS, KumarRK. An improved murine model of asthma: selective airwayinflammation, epithelial lesions and increased methacholineresponsiveness following chronic exposure to aerosolised al-lergen. Thorax. 1998
  14. Holmes AM, Solari R, Holgate ST. Animal models of asthma:value, limitations and opportunities for alternative approac-hes. Drug Discovery Today. 2011
  15. 16(15-16): 659-70. 16.Zosky GR, Sly PD. Animal models of asthma. Clinical and Ex-perimental Allergy, 2007
  16. 37, 973–988. 17.Schneider T, van Velzen D, Moqbel R, Issekutz AC. Kineticsand quantitation of eosinophil and neutrophil recruitment toallergic lung inflammation in a brown Norway rat model. AmJ Respir Cell Mol Biol. 1997
  17. 702–12. 18.Shin YS, Takeda K, Gelfand EW Understanding