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Journals / Health Sciences Quarterly / 2020 / Cilt: 4 - Sayı: 4

EFFECT OF FTO rs9939609 POLIMORPHISM ON OBESITY IN TURKISH POPULATION

Meliha Merve HIZ ÇİÇEKLİYURT
Sevilay OĞUZ KILIÇ
Levent ELMAS
Pages
255–262
Publication Date
2020-11-07
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The relationship between rs9939609 polymorphism and obesity will be highlighted by larger population studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Obesity is a disease that is affected by environmental conditions as well as genetic predisposition.
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Key Findings & Data:This is a case-control study that aimed to investigate the relationship between FTO rs9939609 polymorphism and obesity.
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Conclusion & Impact:The relationship between rs9939609 polymorphism and obesity will be highlighted by larger population studies.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Adiposity · FTO · rs9939609

Abstract

Obesity is a disease that is affected by environmental conditions as well as genetic predisposition. This is a case-control study that aimed to investigate the relationship between FTO rs9939609 polymorphism and obesity. The relation between the rs9939609 polymorphism and obesity in 80 ower-weight (BMI 30) and 131 under/normal weight (BMI 30) subjects was examined. The allele and genotype frequencies of each group were determined by the allele counting method. The relationship between single nucleotide exchange and obesity risk was calculated using the odds ratio. Statistical analyzes were performed with SPSS 18.0. Results: The frequency of T allele was 0.58 and 0.45 respectively in the healthy and overweight group when allele frequencies of both groups were compared. The change in allele frequency increased the obesity rate by 1.8 fold. The rs99399609 polymorphism increases obesity risk by2.7 fold in the homozygotes model. Conclusions: In this research, we found statistically significant results in allele frequency difference and allele positivity. The relationship between rs9939609 polymorphism and obesity will be highlighted by larger population studies.

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Cite This Article

ÇİÇEKLİYURT, M. M. H., KILIÇ, S. O., ELMAS, L. (2020). EFFECT OF FTO rs9939609 POLIMORPHISM ON OBESITY IN TURKISH POPULATION. Health Sciences Quarterly, Cilt: 4 - Sayı: 4, 255–262. https://ajindex.com/articles/836591

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References (7)

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