Association between respiratory function and bone mineral density in pubertal and prepubertal healthy children

When controlled for puberty, FVC percent predicted values were positively associated with BMI SDS (r=0.35, p=0,004) and MAC (r=0.29, p=0.018) and FEV1/FVC percent predicted values were negatively correlated with BMI SDS (r=-0.40, p=0.001) and MAC (r=-0.485, p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: We aimed to evaluate whether the variation in bone mineral density (BMD) measures correlates with the respiratory function parameters and to determine the association between lung function tests and anthropometric indices in healthy pubertal and prepubertal children.

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Key Findings & Data:Methods: We recruited 73 school children.

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Conclusion & Impact:When controlled for puberty, FVC percent predicted values were positively associated with BMI SDS (r=0.35, p=0,004) and MAC (r=0.29, p=0.018) and FEV1/FVC percent predicted values were negatively correlated with BMI SDS (r=-0.40, p=0.001) and MAC (r=-0.485, p

🔬Design:Survey & Empirical Study

📍Scope:Comprehensive Sample

⚙️Variables:respiratory function · bone mineral density · healthy children

Abstract

Aim: We aimed to evaluate whether the variation in bone mineral density (BMD) measures correlates with the respiratory function parameters and to determine the association between lung function tests and anthropometric indices in healthy pubertal and prepubertal children. Methods: We recruited 73 school children. Primary school students were representing prepubertal children and high school students were representing pubertal children. Data collection included a questionnaire and measures of anthropometry, respiratory function and BMD. We investigated the associations between BMD with spirometric parameters and anthropometry with spirometric parameters controlling for pubertal status and other relevant variables. Results: We studied 73 school children (36 prepubertal and 37 pubertal; mean age=12.47±4.26 years). Mean BMD z-score values were significantly different between FEV1 percent predicted quartiles which showed a tendency to increase with the trend in FEV1 percent predicted quartiles. In addition, there was a significant correlation between BMD SOS values and PEF percent predicted values. However, in models controlling for possible confounders, this association of BMD SOS with PEF percent predicted values vanished. When controlled for puberty, FVC percent predicted values were positively associated with BMI SDS (r=0.35, p=0,004) and MAC (r=0.29, p=0.018) and FEV1/FVC percent predicted values were negatively correlated with BMI SDS (r=-0.40, p=0.001) and MAC (r=-0.485, p

Keywords

respiratory function bone mineral density healthy children

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Cite This Article

OZEN, A., SARİCOBAN, H., BERBER, M., SEN, N., YESİLYURT, S., OZDOGAN, S., CENGİZLİER, R. (2012). Association between respiratory function and bone mineral density in pubertal and prepubertal healthy children. Journal of Pediatric Sciences, Cilt: 4 - Sayı: 1, 1–10. https://ajindex.com/articles/836418

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References (10)

Forbes GB. Some remarks on bone mineralization. J Pediatr. 1988;113:167–171.
Southard RN, Morris JD, Mahan JD, et al. Bone mass in healthy children: measurement with quantitative DXA. Radiology. 1991;179:735–738.
Saggese G, Baroncelli GI, Bertelloni S. Puberty and bone development. Best Pract Res Clin Endocrinol Metab. 2000;16:53–64. Matkovic V. Skeletal development and bone turnover revisited. J Clin Endocrinol Metab. 1996;81:2013–6.
Plotkin H, Nunez M, Alvarez Filgueira ML, Zanchetta JR. Lumbar spine bone density in Argentine children. Calcif Tissue Int. 1996;58:144–149. Boot AM, de Ridder AJ, Pols APH. Bone mineral density in children and adolescents: relation to puberty, calcium intake, and physical activity. J Clin Endocrinol Metab. 1997;82:57–62.
Gale CR, Martyn CN, Kellingray S, et al. Intrauterine programming of adult body composition. J Clin Endocrinol Metab. 2001;86:267–72.
Cooper C, Cawley M, Bhalla A, et al. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res. 1995;10:940–7.
Elkin SL, Fairney A, Burnett S, et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a crosssectional study. Osteoporos Int. 2001;12:366–72.
Nishimura Y, Nakata H, Maeda H, Yokoyama M. Bone mineral content in patients with bronchial asthma. Nihon Kyobu Shikkan Gakkai Zasshi. 1995;33:300–5.
Lekamwasam S, Trivedi DP, Khaw KT. An association between respiratory function and bone mineral density in women from the general community: a cross sectional study. Osteoporos Int. 2002;13:710-5.
Lekamwasam S, Trivedi DP, Khaw KT. An association between respiratory function and hip bone mineral density in older men: a cross-sectional study. Osteoporos Int. 2005;16:204-7. Tanner JM: "Growth at Adolescence, with a General Consideration of the Effects of Hereditary and Environmental Factors upon Growth and Maturation from Birth to Maturity," 2nd ed. Oxford: Blackwell, 1962 US Department of Agriculture. National Nutrient Database for Standard Reference, Release 17. http://www.nal.usda.gov/fnic/foodcomp/Data/SR17/wtr ank/sr17a301.pdf Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board. Washington, DC: National Academy Press; 1997 http://www.cdc.gov/growthcharts/percentile_data_files. htm Gonnelli S, Cepollaro C. The use of ultrasound in the assessment of bone status.