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Journals / Journal of Immunology and Clinical Microbiology / 2020 / Cilt: 5 - Sayı: 4

Radiological and histomorphometric investigation of the effectiveness of the Pulsed Electromagnetic Field Therapy (PEMFT) in fracture models that were created in rats

Gülşah YAŞA ÖZTÜRK
Ferda ÖZDEMİR
Selçuk ÖZTÜRK
Cem COPUROGLU
Gülay ALTUN
Mehmet KÜRKCÜ_ÇENE CERRAHİSİ
Nermin TUNÇBİLEK
Necdet SÜT
Pages
139–149
Publication Date
2020-12-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Pulsed electromagnetic field is thought to contribute to the healing of fractures.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In this study, we aimed to investigate the effect of the pulsed electromagnetic field therapy on histomorphometric and radiographic evaluation and bone mineral density of fracture model that were created in rats.
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Key Findings & Data:The study plan: In this study, 14 female young-adult Wistar albino rats that were weighing from 250 to 300 g were used.
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Conclusion & Impact:CONCLUSION: Pulsed electromagnetic field is thought to contribute to the healing of fractures.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Pulsed electromagnetic field · fracture healing · histomorphometry

Abstract

Objective: In this study, we aimed to investigate the effect of the pulsed electromagnetic field therapy on histomorphometric and radiographic evaluation and bone mineral density of fracture model that were created in rats. The study plan: In this study, 14 female young-adult Wistar albino rats that were weighing from 250 to 300 g were used. A closed fracture was created in the tibia of all rats with the guillotine device. 8 rats in the first group underwent 15 sessions of pulsed electromagnetic field therapy at a dose of 15 millitesla/30 minutes a day, whereas 6 rats in the second group were not given any treatment. At the end of 15 sessions of treatment, digital mammographic examination, bone mineral density measurement and histomorphometric evaluation of the fracture area of the rats in the second group were performed. Results: Although there is no statistically significant difference between the two groups after 15 sessions of pulsed electromagnetic field therapy at a dose of 15 millitesla/30 minutes a day, the outcomes of fracture healing were better in the group that received pulsed electromagnetic field therapy than the control group according to radiological score, bone mineral density measurement and histomorphometric evaluation. CONCLUSION: Pulsed electromagnetic field is thought to contribute to the healing of fractures.

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Cite This Article

ÖZTÜRK, G. Y., ÖZDEMİR, F., ÖZTÜRK, S., COPUROGLU, C., ALTUN, G., CERRAHİSİ, M. K., TUNÇBİLEK, N., SÜT, N. (2020). Radiological and histomorphometric investigation of the effectiveness of the Pulsed Electromagnetic Field Therapy (PEMFT) in fracture models that were created in rats. Journal of Immunology and Clinical Microbiology, Cilt: 5 - Sayı: 4, 139–149. https://ajindex.com/articles/835940

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References (14)

  1. REFERENCES 1. Bouxsein ML, Turek TJ, Blake CA. Recombinant human bone morphogenic prtein-2 accelerates healing in a rabbit osteotomy model. J Bone Joint Surg 2001
  2. Higgins TF, Dodds SD, Wolfe SW. A biomechanical analysis of fixation of intra-articular distal radial fractures with calcium-phosphate bone cement. J Bone Joint Surg Am 2002
  3. Leisner S, Shahar R, Aizenberg I, Lichovsky D, Levin-Harrus T. The effect of short-duration, high-intensity electromagnetic pulses on fresh ulnar fractures in rats. J Vet Med A Physiol Pathol Clin Med 2002
  4. Doetsch AM, Faber J, Lynnerup N, Watjen I, Bliddal H, Danneskiold-Samsoe B. The effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study. Calcif Tissue Int 2004
  5. Larrson S, Kim W, Caja VL, Egger EL. Effect of early axial dynamization on tibial bone healing. Clin Orthop Rel Res 2001
  6. Nielsen M, Andreassen T, Ledet T, Oxlund H. Local injection of TGF-β increases the strength of tibial fractures in the rat. Acta Orthopaedica 1994
  7. 65(1):37-41. 7. Nash T, Howlett C, Martin C, Steele J, Johnson K, Hicklin D. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 2009
  8. 15(2):203-8. 8. Wei-Jia C, Seiya J, Ikuo A, Jun A, Goh H, Makoto T et al. Effects of FGF-2 on metaphyseal fracture repair in rabbit tibiae. J Bone Miner Metab 2004
  9. 22(4):303-9. 9. Kloen P, Di Paola M, Borens O, Richmond J, Perino G. BMP signaling components are expressed in human fracture callus. Bone 2003
  10. 33(3):362-71. 10. Mahmoudifar, N. & Doran, P. M. Chondrogenesis and cartilage tissue engineering: the longer road to technology development. Trends Biotechnol 30, 166–76 (2012). 11. Yürekli V, Akkuş S, Akhan G, Tamer MN. Osteomalazi and antiepilepticles. SDÜ Medical Fac. J. 2005
  11. 12(2):34-7. 12. Steward AJ, Kelly DJ, &Wagner DR. The roll of calcium signaling in the chondrogenic response of mesenchymal stem cell to hydrostatic pressure. Eur Cell Mater 2014
  12. 28, 358-71. 13. Pall ML. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. J Cell Mol Med 2013
  13. 17, 958–65. 14. TToh, WS Spector M, Lee, E. H. & Cao, T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Mol Pharm 8, 2011
  14. 994–1001. 15. Raghothaman D, Leong MF, Lim TC, Toh JK, Wan AC, Yang, Z. Lee EH. Engineering cell