SavedAdd your journal

Journals / Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi / 2019 / Cilt: 11 - Sayı: 3

İrisin Irisin: A New Molecule

Yeni Bir Molekül

Banu KABAK
Belma HANER
Abdullah GENÇ
Pages
113–122
Publication Date
2020-06-29
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All of these studies with the aim of drug development against diseases must be maintained.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Irisin, which is called as sports hormone, is a recently discovered new molecule..
📊
Key Findings & Data:It has been secreted within the domain of Fibronectin type III domain containing 5 (FNDC5) of the skeletal muscle.
💡
Conclusion & Impact:All of these studies with the aim of drug development against diseases must be maintained.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İrisin · Yağ dokusu · Enerji metabolizması

Abstract

Aim: Irisin, which is called as sports hormone, is a recently discovered new molecule.. It has been secreted within the domain of Fibronectin type III domain containing 5 (FNDC5) of the skeletal muscle. It is said that irisin has played an important role in converting white adipose tissue to brown adipose tissue and regulating energy metabolism. However, due to the conflicting results of the studies, it has encountered secretion, level of circulation, and detection of some problems. Material and method: Literature search was conducted to get the current information about FNDC5 / Irisin. Findings and results: Studies on the discovery, physiological and pathological effects of the irisin were examined, also present objections, and expectations for the future were discussed. The current and future research on the irisin promises hope. All of these studies with the aim of drug development against diseases must be maintained.

Özet

Amaç: Spor hormonu olarak adlandırılan İrisin son zamanlarda keşfedilen yeni bir moleküldür. İskelet kasının Fibronectin type III domain containing 5 (FNDC5) etki alanı içerisinde salgılanmaktadır. Beyaz adipoz dokunun kahverengi adipoz dokuya dönüştürülmesinde ve enerji metabolizmasının düzenlenmesinde önemli bir rol oynadığı ileri sürülmektedir. Ancak çalışmalarda ki çelişkili sonuçlar nedeniyle; salgılanmasında, dolaşım seviyesinde ve tespit edilmesinde bazı sorunlarla karşılaşılmaktadır. Gereç ve Yöntem: FNDC5 / irisin hakkında mevcut bilgileri toplamak için literatür taraması yapılmıştır. Bulgular ve sonuçlar: İrisinin keşfi, fizyolojik ve patolojik etkileri üzerine yapılan çalışmalar incelenmiş, ayrıca mevcut itirazlar ve gelecek beklentileri tartışılmıştır. İrisin üzerindeki güncel ve gelecek araştırmalar umut vadetmektedir. Tüm bu çalışmaların hastalıklara karşı ilaç hedeflerini gerçekleştirmek amacıyla yoğun bir şekilde sürdürülmesi gerekmektedir.

🔖

Cite This Article

KABAK, B., HANER, B., GENÇ, A. (2020). İrisin Irisin: A New Molecule. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, Cilt: 11 - Sayı: 3, 113–122. https://ajindex.com/articles/831065

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Spiegelman BM, A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy, Cell, 2012, 151, 1319–1331
  2. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA,Bostrom EA, Choi JH, Long JZ et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat andthermogenesis. Nature 2012 481 463–468. (doi:10.1038/nature10777
  3. Pedersen BK, Muscle as a secretory organ. Com Physiol 2013, 3, 1337-1362
  4. Casteilla L, Blondel O, Klaus S, Raimbault S, Diolezt P, Moreaut F, Bouillaud F, Ricquier D, Stable expression of functional mitochondrial uncoupling protein in Chinese hamster ovary cells, Proc Natl Acad Sci 1990, 87, 5124-5128
  5. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM, Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1, Cell,1999, 98, 115–124
  6. Pilegaard H, Saltin B, Neufer DP, Exercise induces transient transcriptional activation of the PGC-1 α gene in human skeletal muscle, J Physiol 2003, 546, 3, 851–858
  7. Baar K, Wende AR, Jones ET, Marrison M, Nolte LA, Chen M, Kelly DP, Holloszy JO, Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1 α, FASEB Journal 2002. 16, 1879–1886
  8. Rodgers JT, Lerin C, Hines ZG, Puigserver P, Metabolic adaptations through the PGC-1α and SIRT1 pathways, FEBS Lett, 2008, 582, 46–53
  9. Eisele PS, Furrer R, Beer M, Handschin C, 2015. The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo, Biochem Biophys Res Commun,2015,, 464, 3, 692-697
  10. Courage KH, Newly discovered hormone boosts effects of exercise, could help fend off diabetes, 2012, Observations Scientific American Retrieved, January 12
  11. Park A, Brown Fat: A fat that helps you lose weight?, Retrieved January 2009, 12, 2012
  12. Kelly DP, Irisin, light my fire, Science, 2012, 336, 42-43
  13. Castillo-Quan JI, From white to brown fat trough the PCG 1 α –dependent myokine irisin: Implications for diabetes and obesity, Dis Model Mech, 2012, 5,293-295
  14. Erickson HP, Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor?, Adipocytes 2013, 2 289–293. (doi:10.4161/adip. 26082
  15. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisloff U, Tjonna AE, Raastad T et al. Evidence against a beneficial effect of irisin in humans, PLoS ON