Journals / Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi / 2013 / Cilt: 5 - Sayı: 2

Primary Hyperparathyroidism and Sarcoidosis without Organ Involvement in a Patient with Asymptomatic Hypercalcemia and Normal Vitamin-D and ACE Concentrations

Asemptomatik Hiperkalsemi, Normal D Vitamin ve ACE Değerleri İzlenen Primer Hiperparatiroidi ve Organ Tutulumu Olmayan Sarkoidoz Olgusu

Pages
109–113
Publication Date
2013-06-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Interestingly, patients preoperative tests revealed normal 1,25(OH)2D3 concentration and normal serum ACE levels that we eliminated diagnosis of sarcoidosis before surgery but surprisingly pathology results present regular thymus tissue and non-caseating granulomatous lympadenitis which histologically confirmed sarcoidosis.

📌 3 Key Takeaways

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Objective & Hypothesis:We present an unusual case of a 56 year old woman who admitted to our hospital with complaints of fatigue and sore throat.
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Key Findings & Data:We determined high plasma parathyroid hormone level but ultrasonography and Tc-99m MIBI requested for parathyroid imaging were unremarkable for parathyroid mass.
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Conclusion & Impact:Interestingly, patients preoperative tests revealed normal 1,25(OH)2D3 concentration and normal serum ACE levels that we eliminated diagnosis of sarcoidosis before surgery but surprisingly pathology results present regular thymus tissue and non-caseating granulomatous lympadenitis which histologically confirmed sarcoidosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hiperkalsemi · hiperparatiroidi · sarkoidoz

Abstract

We present an unusual case of a 56 year old woman who admitted to our hospital with complaints of fatigue and sore throat. On admission, laboratory data showed hypercalcemia incidentally and therefore the patient consulted to our outpatient clinic. We determined high plasma parathyroid hormone level but ultrasonography and Tc-99m MIBI requested for parathyroid imaging were unremarkable for parathyroid mass. We performed PET CT scan for detecting ectopic glands and exclude malignancy at the same time and scan revealed multiple F-18 FDG involvement in mediastinum which were surgically removed. Interestingly, patients preoperative tests revealed normal 1,25(OH)2D3 concentration and normal serum ACE levels that we eliminated diagnosis of sarcoidosis before surgery but surprisingly pathology results present regular thymus tissue and non-caseating granulomatous lympadenitis which histologically confirmed sarcoidosis.

Özet

Burada yorgunluk ve boğaz ağrısı nedeniyle hastanemize kabul edilmiş 56 yaşında bayan hastamızı sunmaktayız. Hastanın hastanemize kabulü sırasında yapılan laboratuar incelemesinde insidental hiperkalsemi tespit edilmesi üzerine kliniğimize konsülte edildi. Yüksek plazma paratiroid seviyelerine rağmen hastanın paratiroid görüntülemesi için istenen ultrasonografi ve Tc-99m MIBI görüntülemelerinde paratiroidler izlenemedi. Ektopik bezlerin tespiti ve malignite ekartasyonu amacıyla yapılan PET BT’de ise mediastende multipl F-18 FDG tutulumları izlendi ve lezyonlar cerrahi olarak çıkarıldı. İlginç olan durum ise, hastanın preoperatif testlerinde serum 1,25(OH)2 D3 ve ACE düzeylerinin normal olması ve dolayısıyla cerrahi öncesi sarkoidoz tanısı ekarte edilmiş olmasına rağmen patolojik incelemenin normal timus dokusu ve histolojik olarakta sarkoidozla uyumlu olan non-kazeöz granülomatöz lenfadenit olarak değerlendirilmesiydi.

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Cite This Article

ÇOLAKOĞLU, M. K., YENİDOĞAN, E., GÜLCELİK, M. A., BİLİR, G., GULCELİK, N. E., AKGUL, G. G., OZDEMİR, Y. (2013). Primary Hyperparathyroidism and Sarcoidosis without Organ Involvement in a Patient with Asymptomatic Hypercalcemia and Normal Vitamin-D and ACE Concentrations. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, Cilt: 5 - Sayı: 2, 109–113. https://ajindex.com/articles/829218

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