Journals / Turkish Journal of Health Science and Life / 2022 / Cilt: 5 - Sayı: 2

An experimental study to investigate the impact of Aspirin and Vitamin C therapy on fructose induced hepatic and pancreatic damage

Pages
121–131
Publication Date
2022-08-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that serum cholesterol and AST levels were significantly lower in the F+C and F+A+C groups, and ALT and TG levels were significantly lower in the F+A+C group compared to the F group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:It is assumed that excessive fructose consumption is associated with the risk of developing various diseases, especially metabolic disease.
📊
Key Findings & Data:The aims of this study were two fold: 1) Does liver and pancreatic damage occur due to excessive fructose consumption 2) If damage occurs, can we reduce this damage by using (ASA) and Vit.
💡
Conclusion & Impact:It was found that serum cholesterol and AST levels were significantly lower in the F+C and F+A+C groups, and ALT and TG levels were significantly lower in the F+A+C group compared to the F group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Aspirin · Vitamin C · Corn syrup

Abstract

It is assumed that excessive fructose consumption is associated with the risk of developing various diseases, especially metabolic disease. The aims of this study were two fold: 1) Does liver and pancreatic damage occur due to excessive fructose consumption 2) If damage occurs, can we reduce this damage by using (ASA) and Vit. C. The rats were divided randomly into five groups of eight as follows: Group1-control; Group2-corn syrup (Fructose: F; 30% F solution); Group3-F and ASA (F+10 mg/kg/day, ASA, oral); Group4-F and Vit. C (F+200 mg/kg/day, Vit. C, oral); Group5-F, ASA and Vit C (F+A+C -same dose administration, respectively). The rats were sacrificed 24 h after the last application at the end of the 6th week, and their blood serum, liver and pancreas tissues were taken and evaluated histologically and biochemically. It was found that serum cholesterol and AST levels were significantly lower in the F+C and F+A+C groups, and ALT and TG levels were significantly lower in the F+A+C group compared to the F group (p

🔖

Cite This Article

YEŞİLOT, Ş., ÖZER, M. K., GÜLTEKİN, F., ÖNCÜ, M., CANDAN, İ. A., DAĞDEVİREN, B. H., ÇİÇEK, E. (2022). An experimental study to investigate the impact of Aspirin and Vitamin C therapy on fructose induced hepatic and pancreatic damage. Turkish Journal of Health Science and Life, Cilt: 5 - Sayı: 2, 121–131. https://ajindex.com/articles/808885

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Aşıcı N, Oturak G, Ekerbiçer H. Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. Sakarya Tıp Dergisi. 2020; 10(Özel Sayı): 57-68
  2. Parker K, Salas M, Nwosu VC. High fructose corn syrup: production, uses and public health concerns. Biotechnol Mol Biol Rev. 2010:5(5):71–78 3. Pepin A, Stanhope KL, Imbeult P. Are Fruit Juices Healthier Th an Sugar-Sweetened Beverages? A Review. Nutrients 2019; 11(5):1006
  3. Ventura EE, Davis JN, Goran MI. Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content. Obesity. 2011, 19, 868–874 5. Hühnerfuss H. Carbohydrate-Modifying Biocatalysts. Chapter-Basics in Carbohydrate Chemistry 1st Edition. Jenny Stanford Publishing. 2012. eBook ISBN9780429067396 6. Korkmaz A. Fructose; a Hidden Threat for Chronic Diseases. TAF Prev Med Bull 2008; 7(4):343-346 7. Arslan S, Şanlıer N. Fruktoz ve sağlık. Mersin Univ Saglık Bilim derg. 2016; 9(3): 150-158
  4. Kanazawa J, Kakisaka K, Suzuki Y, Yonezawa T, Abe H, Wang T, Takikawa Y. Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes, The Journal of Nutritional Biochemistry, 2022; 107,109052
  5. White J, Hobbs L. & Fernandez S. Fructose content and composition of commercial HFCS-sweetened carbonated beverages. Int J Obes 2015;.39, 176–182 10. G Ang BR, Yu GF. Th e Role of Fructose in Type 2 Diabetes and Other Metabolic Diseases. J Nutr Food Sci 2018;8(1):1-4
  6. Hu FB, Malik VS. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence. Physiol. Behav. 2010; 100(1): 47–54
  7. Teff KL, Grudziak J, Townsend RR, Dunn TN, Grant RW, et al. Endocrine and metabolic effects of consuming fructose and glucose- sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab. 2009;94: 1562-1569. 19
  8. Tappy L, Egli L, Lecoultre V, Schneider P. Effects of fructose-containing caloric sweeteners on resting energy expenditure and energy efficiency: a review of human trials. Nutr Metab 2013; 10: 54. 14. https://www.who.int/publications/i/item/9789241549028 (Access Date: 01.07.2022). 15. https://www.fda.gov/food/food-additives-petitions/high-fructose-corn-syrup-questions-and-answers (Access Date: 01.07.2022)
  9. Yan S, Yang H, Lee H, Yin M. Protective effects of maslinic acid against alcohol-induced acute liver injury in mice,