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Journals / Selçuk Üniversitesi Fen Fakültesi Fen Dergisi / 2022 / Cilt: 48 - Sayı: 2

Synthesis and Characterization of A New Probe For The Detection of Cystein

Sistein Tayini İçin Yeni Bir Algılayıcı Molekülün Sentezi ve Karakterizasyonu

Sait MALKONDU
Serkan ERDEMİR
Pages
79–87
Publication Date
2022-10-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, the interaction mechanism between the probe and cysteine has been investigated through theoretical calculations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cysteine is an amino acid containing a thiol group, which has important roles in living organisms.
📊
Key Findings & Data:Therefore, the determination of the presence and amount of cysteine is one of the main topics of interest for researchers.
💡
Conclusion & Impact:In addition, the interaction mechanism between the probe and cysteine has been investigated through theoretical calculations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sistein · algılayıcı · fluoresans

Abstract

Cysteine is an amino acid containing a thiol group, which has important roles in living organisms. Therefore, the determination of the presence and amount of cysteine is one of the main topics of interest for researchers. In the present study, a new benzothiazole-based sensor has been designed to detect cysteine by fluorescence method based on ESIPT mechanism. The molecule structure of the target probe molecule has been confirmed by methods such as FT-IR, NMR and MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization time-of- flight) mass spectroscopy. In addition, the interaction mechanism between the probe and cysteine has been investigated through theoretical calculations.

Özet

Sistein canlı organizmada önemli rolleri olan tiyol grubu içeren bir amino asittir. Dolayısıyla sistein varlığının ve miktarının tespit edilmesi araştırmacıların ilgilendiği konuların başında gelmektedir. Bu çalışmada, sisteini ESIPT mekanizmasına dayalı fluoresans metodu ile tayin etmek amacı ile benzotiyazol temelli yeni bir algılayıcı molekül tasarlanmıştır. Hedef algılayıcının molekül yapısı FT-IR, NMR ve MALDI-TOF (Matriks aracılı lazer dezorpsiyon iyonizasyon uçuş zamanı) kütle spektrokopisi gibi metotlarla aydınlatılmıştır. Ayrıca, algılayıcı ve sistein arasındaki etkileşim mekanizması teorik hesaplamalar aracılığıyla incelenmiştir.

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Cite This Article

MALKONDU, S., ERDEMİR, S. (2022). Synthesis and Characterization of A New Probe For The Detection of Cystein. Selçuk Üniversitesi Fen Fakültesi Fen Dergisi, Cilt: 48 - Sayı: 2, 79–87. https://ajindex.com/articles/800274

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